MK‐801 Prevents 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐Induced Parkinsonism in Primates

: In cynomologus monkeys, systemic administration of MK‐801, a noncompetitive antagonist for the N‐methyl‐4‐aspartate receptor, prevented the development of the parkinsonian syndrome induced by the neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP). MK‐801 also attenuated dopamine deplet...

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Veröffentlicht in:	Journal of neurochemistry 1992-08, Vol.59 (2), p.733-739
Hauptverfasser:	Zuddas, Alessandro, Oberto, Germano, Vaglini, Francesca, Fascetti, Flavia, Fornai, Francesco, Corsini, Giovanni U.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - adverse effects 1-Methyl-4-phenylpyridinium - metabolism 1‐Methyl‐4‐phenylpyridinium Animals Biochemistry & Molecular Biology Biological and medical sciences Caudate Nucleus - drug effects Disease Models, Animal Dizocilpine Maleate - pharmacology Dopamine Dopamine - metabolism Dose-Response Relationship, Drug Excitatory amino acids Life Sciences & Biomedicine Macaca fascicularis Male Medical sciences MK‐801‐1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine Nerve Degeneration - drug effects Nervous system involvement in other diseases. Miscellaneous Neurology Neurons - drug effects Neurosciences Neurosciences & Neurology Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - metabolism Parkinson Disease, Secondary - prevention & control Parkinsonism Putamen - drug effects Science & Technology Substantia Nigra - drug effects Substantia nigra degeneration
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