Sarcoidosis, myasthenia gravis and anterior ischaemic optic neuropathy: severe side effects of adjuvant interferon-alpha-therapy in malignant melanoma?
In dermato-oncology, interferon-alpha is widely used as treatment of cutaneous lymphoma and as adjuvant therapy in high risk malignant melanoma. With increasingly wide administration of interferon-alpha (IFN-alpha), not only early-onset side effects, such as influenza-like symptoms, but also uncommo...
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| Veröffentlicht in: | Journal der Deutschen Dermatologischen Gesellschaft 2004-08, Vol.2 (8), p.689 |
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| creator | Kreutzer, Katharina Bonnekoh, Bernd Franke, Ingolf Ulrich, Jens Gollnick, Harald |
| description | In dermato-oncology, interferon-alpha is widely used as treatment of cutaneous lymphoma and as adjuvant therapy in high risk malignant melanoma. With increasingly wide administration of interferon-alpha (IFN-alpha), not only early-onset side effects, such as influenza-like symptoms, but also uncommon late-onset side effects are being recognized. We present three patients with melanoma who developed rare side effects in the course of adjuvant IFN-alpha-therapy: sarcoidosis, myasthenia gravis and anterior ischaemic optic neuropathy. Based on current knowledge a causal relationship between these diseases and the administration of IFN-alpha can neither be affirmed or absolutely ruled out. Therefore special attention should be paid to such coincidences. |
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With increasingly wide administration of interferon-alpha (IFN-alpha), not only early-onset side effects, such as influenza-like symptoms, but also uncommon late-onset side effects are being recognized. We present three patients with melanoma who developed rare side effects in the course of adjuvant IFN-alpha-therapy: sarcoidosis, myasthenia gravis and anterior ischaemic optic neuropathy. Based on current knowledge a causal relationship between these diseases and the administration of IFN-alpha can neither be affirmed or absolutely ruled out. Therefore special attention should be paid to such coincidences.</abstract><cop>Germany</cop><pmid>16279234</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1610-0379 |
| ispartof | Journal der Deutschen Dermatologischen Gesellschaft, 2004-08, Vol.2 (8), p.689 |
| issn | 1610-0379 |
| language | ger |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Chemotherapy, Adjuvant - adverse effects Female Humans Interferon-alpha - adverse effects Interferon-alpha - therapeutic use Male Melanoma - complications Melanoma - drug therapy Middle Aged Myasthenia Gravis - chemically induced Myasthenia Gravis - diagnosis Myasthenia Gravis - prevention & control Optic Neuropathy, Ischemic - chemically induced Optic Neuropathy, Ischemic - diagnosis Optic Neuropathy, Ischemic - prevention & control Sarcoidosis - chemically induced Sarcoidosis - diagnosis Sarcoidosis - prevention & control Skin Neoplasms - complications Skin Neoplasms - drug therapy Treatment Outcome |
| title | Sarcoidosis, myasthenia gravis and anterior ischaemic optic neuropathy: severe side effects of adjuvant interferon-alpha-therapy in malignant melanoma? |
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