Analysis of cell populations in rheumatoid arthritis synovial tissues

Knee synovium, taken from patients with rheumatoid arthritis at the time of arthroplasty, was studied immunohistologically. Focal perivascular lymphoid infiltrates of different sizes were examined in detail to evaluate changes in cell populations as the infiltrate size increased. T cells formed the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Seminars in arthritis and rheumatism 1992-06, Vol.21 (6), p.393-399
Hauptverfasser: Yanni, Ghada, Whelan, Alex, Feighery, Conleth, Bresnihan, Barry
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 399
container_issue 6
container_start_page 393
container_title Seminars in arthritis and rheumatism
container_volume 21
creator Yanni, Ghada
Whelan, Alex
Feighery, Conleth
Bresnihan, Barry
description Knee synovium, taken from patients with rheumatoid arthritis at the time of arthroplasty, was studied immunohistologically. Focal perivascular lymphoid infiltrates of different sizes were examined in detail to evaluate changes in cell populations as the infiltrate size increased. T cells formed the largest component of mononuclear cells of all aggregates. The large grade 3 aggregates contained substantial numbers of B cells arranged around a central venule and cells bearing the CD45RA+ phenotype. In contrast, the small grade 1 aggregates contained few B cells and the T-cell population contained relatively greater numbers of CD8+ cells. Cells bearing the CD45RO+ phenotype exceeded CD45RA+ cells in grade 1 aggregates. Detailed analysis of mononuclear cell aggregates of different sizes in the rheumatoid synovium suggests that the composition of each aggregate depends on the total number of mononuclear cells it contains.
doi_str_mv 10.1016/0049-0172(92)90040-K
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_1626285</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>004901729290040K</els_id><sourcerecordid>73057137</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-a93d2d91438e9dfd30cf27ed7bde02a09b323117fa39b494c7a08f718948a3ae3</originalsourceid><addsrcrecordid>eNqNkF1rFDEUhkNR6rb6DyrMhUiLjM3H7CS5KSxLP6QFbxSKN-FMPmhkdrImmcr--2acZb0TQyAczvOeJA9CZwR_Jpi0lxg3ssaE03NJL2SpcH1_hBZkyWgt2vbxFVockDfoJKWfGBPSYn6MjklLWyqWC3S9GqDfJZ-q4Cpt-77ahu3YQ_ZhSJUfqvhkxw3k4E0FMT9FnwubdkN49tBXpUijTW_Rawd9su_25yn6fnP9bX1XP3y9_bJePdS6ESTXIJmhRpKGCSuNMwxrR7k1vDMWU8CyY5QRwh0w2TWy0RywcJwI2QhgYNkp-jjP3cbwq9yb1can6dUw2DAmxRlecsJ4AZsZ1DGkFK1T2-g3EHeKYDXZU5MaNalRsuzJnrovsff7-WO3seZvaNZV-h_2fUgaehdh0D4dsCWTTHJcMDFjv20XXNLeDtoeqBWRkt79oFzgstq1z39sr8M45BL99P_RQl_NtC3Sn72Nap8wPlqdlQn-3x9-AW8FrSk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73057137</pqid></control><display><type>article</type><title>Analysis of cell populations in rheumatoid arthritis synovial tissues</title><source>Web of Science - Science Citation Index Expanded - 1992&lt;img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /&gt;</source><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Yanni, Ghada ; Whelan, Alex ; Feighery, Conleth ; Bresnihan, Barry</creator><creatorcontrib>Yanni, Ghada ; Whelan, Alex ; Feighery, Conleth ; Bresnihan, Barry</creatorcontrib><description>Knee synovium, taken from patients with rheumatoid arthritis at the time of arthroplasty, was studied immunohistologically. Focal perivascular lymphoid infiltrates of different sizes were examined in detail to evaluate changes in cell populations as the infiltrate size increased. T cells formed the largest component of mononuclear cells of all aggregates. The large grade 3 aggregates contained substantial numbers of B cells arranged around a central venule and cells bearing the CD45RA+ phenotype. In contrast, the small grade 1 aggregates contained few B cells and the T-cell population contained relatively greater numbers of CD8+ cells. Cells bearing the CD45RO+ phenotype exceeded CD45RA+ cells in grade 1 aggregates. Detailed analysis of mononuclear cell aggregates of different sizes in the rheumatoid synovium suggests that the composition of each aggregate depends on the total number of mononuclear cells it contains.</description><identifier>ISSN: 0049-0172</identifier><identifier>EISSN: 1532-866X</identifier><identifier>DOI: 10.1016/0049-0172(92)90040-K</identifier><identifier>PMID: 1626285</identifier><identifier>CODEN: SAHRBF</identifier><language>eng</language><publisher>PHILADELPHIA: Elsevier Inc</publisher><subject>Antigens, CD - analysis ; Arthritis, Rheumatoid - pathology ; B-Lymphocytes - pathology ; Biological and medical sciences ; Diseases of the osteoarticular system ; Humans ; Immunohistochemistry ; Inflammatory joint diseases ; Leukocyte Count ; Life Sciences &amp; Biomedicine ; Medical sciences ; Rheumatology ; Science &amp; Technology ; Synovial Membrane - pathology ; T-Lymphocytes - pathology</subject><ispartof>Seminars in arthritis and rheumatism, 1992-06, Vol.21 (6), p.393-399</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>45</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992HZ27800006</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c481t-a93d2d91438e9dfd30cf27ed7bde02a09b323117fa39b494c7a08f718948a3ae3</citedby><cites>FETCH-LOGICAL-c481t-a93d2d91438e9dfd30cf27ed7bde02a09b323117fa39b494c7a08f718948a3ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0049-0172(92)90040-K$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>310,311,315,782,786,791,792,3552,23937,23938,25147,27199,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=5393970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1626285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yanni, Ghada</creatorcontrib><creatorcontrib>Whelan, Alex</creatorcontrib><creatorcontrib>Feighery, Conleth</creatorcontrib><creatorcontrib>Bresnihan, Barry</creatorcontrib><title>Analysis of cell populations in rheumatoid arthritis synovial tissues</title><title>Seminars in arthritis and rheumatism</title><addtitle>SEMIN ARTHRITIS RHEU</addtitle><addtitle>Semin Arthritis Rheum</addtitle><description>Knee synovium, taken from patients with rheumatoid arthritis at the time of arthroplasty, was studied immunohistologically. Focal perivascular lymphoid infiltrates of different sizes were examined in detail to evaluate changes in cell populations as the infiltrate size increased. T cells formed the largest component of mononuclear cells of all aggregates. The large grade 3 aggregates contained substantial numbers of B cells arranged around a central venule and cells bearing the CD45RA+ phenotype. In contrast, the small grade 1 aggregates contained few B cells and the T-cell population contained relatively greater numbers of CD8+ cells. Cells bearing the CD45RO+ phenotype exceeded CD45RA+ cells in grade 1 aggregates. Detailed analysis of mononuclear cell aggregates of different sizes in the rheumatoid synovium suggests that the composition of each aggregate depends on the total number of mononuclear cells it contains.</description><subject>Antigens, CD - analysis</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>B-Lymphocytes - pathology</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammatory joint diseases</subject><subject>Leukocyte Count</subject><subject>Life Sciences &amp; Biomedicine</subject><subject>Medical sciences</subject><subject>Rheumatology</subject><subject>Science &amp; Technology</subject><subject>Synovial Membrane - pathology</subject><subject>T-Lymphocytes - pathology</subject><issn>0049-0172</issn><issn>1532-866X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkF1rFDEUhkNR6rb6DyrMhUiLjM3H7CS5KSxLP6QFbxSKN-FMPmhkdrImmcr--2acZb0TQyAczvOeJA9CZwR_Jpi0lxg3ssaE03NJL2SpcH1_hBZkyWgt2vbxFVockDfoJKWfGBPSYn6MjklLWyqWC3S9GqDfJZ-q4Cpt-77ahu3YQ_ZhSJUfqvhkxw3k4E0FMT9FnwubdkN49tBXpUijTW_Rawd9su_25yn6fnP9bX1XP3y9_bJePdS6ESTXIJmhRpKGCSuNMwxrR7k1vDMWU8CyY5QRwh0w2TWy0RywcJwI2QhgYNkp-jjP3cbwq9yb1can6dUw2DAmxRlecsJ4AZsZ1DGkFK1T2-g3EHeKYDXZU5MaNalRsuzJnrovsff7-WO3seZvaNZV-h_2fUgaehdh0D4dsCWTTHJcMDFjv20XXNLeDtoeqBWRkt79oFzgstq1z39sr8M45BL99P_RQl_NtC3Sn72Nap8wPlqdlQn-3x9-AW8FrSk</recordid><startdate>19920601</startdate><enddate>19920601</enddate><creator>Yanni, Ghada</creator><creator>Whelan, Alex</creator><creator>Feighery, Conleth</creator><creator>Bresnihan, Barry</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920601</creationdate><title>Analysis of cell populations in rheumatoid arthritis synovial tissues</title><author>Yanni, Ghada ; Whelan, Alex ; Feighery, Conleth ; Bresnihan, Barry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-a93d2d91438e9dfd30cf27ed7bde02a09b323117fa39b494c7a08f718948a3ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Antigens, CD - analysis</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>B-Lymphocytes - pathology</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inflammatory joint diseases</topic><topic>Leukocyte Count</topic><topic>Life Sciences &amp; Biomedicine</topic><topic>Medical sciences</topic><topic>Rheumatology</topic><topic>Science &amp; Technology</topic><topic>Synovial Membrane - pathology</topic><topic>T-Lymphocytes - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yanni, Ghada</creatorcontrib><creatorcontrib>Whelan, Alex</creatorcontrib><creatorcontrib>Feighery, Conleth</creatorcontrib><creatorcontrib>Bresnihan, Barry</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yanni, Ghada</au><au>Whelan, Alex</au><au>Feighery, Conleth</au><au>Bresnihan, Barry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of cell populations in rheumatoid arthritis synovial tissues</atitle><jtitle>Seminars in arthritis and rheumatism</jtitle><stitle>SEMIN ARTHRITIS RHEU</stitle><addtitle>Semin Arthritis Rheum</addtitle><date>1992-06-01</date><risdate>1992</risdate><volume>21</volume><issue>6</issue><spage>393</spage><epage>399</epage><pages>393-399</pages><issn>0049-0172</issn><eissn>1532-866X</eissn><coden>SAHRBF</coden><abstract>Knee synovium, taken from patients with rheumatoid arthritis at the time of arthroplasty, was studied immunohistologically. Focal perivascular lymphoid infiltrates of different sizes were examined in detail to evaluate changes in cell populations as the infiltrate size increased. T cells formed the largest component of mononuclear cells of all aggregates. The large grade 3 aggregates contained substantial numbers of B cells arranged around a central venule and cells bearing the CD45RA+ phenotype. In contrast, the small grade 1 aggregates contained few B cells and the T-cell population contained relatively greater numbers of CD8+ cells. Cells bearing the CD45RO+ phenotype exceeded CD45RA+ cells in grade 1 aggregates. Detailed analysis of mononuclear cell aggregates of different sizes in the rheumatoid synovium suggests that the composition of each aggregate depends on the total number of mononuclear cells it contains.</abstract><cop>PHILADELPHIA</cop><pub>Elsevier Inc</pub><pmid>1626285</pmid><doi>10.1016/0049-0172(92)90040-K</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0049-0172
ispartof Seminars in arthritis and rheumatism, 1992-06, Vol.21 (6), p.393-399
issn 0049-0172
1532-866X
language eng
recordid cdi_pubmed_primary_1626285
source Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; Access via ScienceDirect (Elsevier)
subjects Antigens, CD - analysis
Arthritis, Rheumatoid - pathology
B-Lymphocytes - pathology
Biological and medical sciences
Diseases of the osteoarticular system
Humans
Immunohistochemistry
Inflammatory joint diseases
Leukocyte Count
Life Sciences & Biomedicine
Medical sciences
Rheumatology
Science & Technology
Synovial Membrane - pathology
T-Lymphocytes - pathology
title Analysis of cell populations in rheumatoid arthritis synovial tissues
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-06T12%3A19%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%20cell%20populations%20in%20rheumatoid%20arthritis%20synovial%20tissues&rft.jtitle=Seminars%20in%20arthritis%20and%20rheumatism&rft.au=Yanni,%20Ghada&rft.date=1992-06-01&rft.volume=21&rft.issue=6&rft.spage=393&rft.epage=399&rft.pages=393-399&rft.issn=0049-0172&rft.eissn=1532-866X&rft.coden=SAHRBF&rft_id=info:doi/10.1016/0049-0172(92)90040-K&rft_dat=%3Cproquest_pubme%3E73057137%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73057137&rft_id=info:pmid/1626285&rft_els_id=004901729290040K&rfr_iscdi=true