Analysis of cell populations in rheumatoid arthritis synovial tissues

Knee synovium, taken from patients with rheumatoid arthritis at the time of arthroplasty, was studied immunohistologically. Focal perivascular lymphoid infiltrates of different sizes were examined in detail to evaluate changes in cell populations as the infiltrate size increased. T cells formed the...

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Veröffentlicht in:Seminars in arthritis and rheumatism 1992-06, Vol.21 (6), p.393-399
Hauptverfasser: Yanni, Ghada, Whelan, Alex, Feighery, Conleth, Bresnihan, Barry
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container_title Seminars in arthritis and rheumatism
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creator Yanni, Ghada
Whelan, Alex
Feighery, Conleth
Bresnihan, Barry
description Knee synovium, taken from patients with rheumatoid arthritis at the time of arthroplasty, was studied immunohistologically. Focal perivascular lymphoid infiltrates of different sizes were examined in detail to evaluate changes in cell populations as the infiltrate size increased. T cells formed the largest component of mononuclear cells of all aggregates. The large grade 3 aggregates contained substantial numbers of B cells arranged around a central venule and cells bearing the CD45RA+ phenotype. In contrast, the small grade 1 aggregates contained few B cells and the T-cell population contained relatively greater numbers of CD8+ cells. Cells bearing the CD45RO+ phenotype exceeded CD45RA+ cells in grade 1 aggregates. Detailed analysis of mononuclear cell aggregates of different sizes in the rheumatoid synovium suggests that the composition of each aggregate depends on the total number of mononuclear cells it contains.
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source Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; Access via ScienceDirect (Elsevier)
subjects Antigens, CD - analysis
Arthritis, Rheumatoid - pathology
B-Lymphocytes - pathology
Biological and medical sciences
Diseases of the osteoarticular system
Humans
Immunohistochemistry
Inflammatory joint diseases
Leukocyte Count
Life Sciences & Biomedicine
Medical sciences
Rheumatology
Science & Technology
Synovial Membrane - pathology
T-Lymphocytes - pathology
title Analysis of cell populations in rheumatoid arthritis synovial tissues
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