Analysis of cell populations in rheumatoid arthritis synovial tissues
Knee synovium, taken from patients with rheumatoid arthritis at the time of arthroplasty, was studied immunohistologically. Focal perivascular lymphoid infiltrates of different sizes were examined in detail to evaluate changes in cell populations as the infiltrate size increased. T cells formed the...
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| Veröffentlicht in: | Seminars in arthritis and rheumatism 1992-06, Vol.21 (6), p.393-399 |
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| container_title | Seminars in arthritis and rheumatism |
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| creator | Yanni, Ghada Whelan, Alex Feighery, Conleth Bresnihan, Barry |
| description | Knee synovium, taken from patients with rheumatoid arthritis at the time of arthroplasty, was studied immunohistologically. Focal perivascular lymphoid infiltrates of different sizes were examined in detail to evaluate changes in cell populations as the infiltrate size increased. T cells formed the largest component of mononuclear cells of all aggregates. The large grade 3 aggregates contained substantial numbers of B cells arranged around a central venule and cells bearing the CD45RA+ phenotype. In contrast, the small grade 1 aggregates contained few B cells and the T-cell population contained relatively greater numbers of CD8+ cells. Cells bearing the CD45RO+ phenotype exceeded CD45RA+ cells in grade 1 aggregates. Detailed analysis of mononuclear cell aggregates of different sizes in the rheumatoid synovium suggests that the composition of each aggregate depends on the total number of mononuclear cells it contains. |
| doi_str_mv | 10.1016/0049-0172(92)90040-K |
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Focal perivascular lymphoid infiltrates of different sizes were examined in detail to evaluate changes in cell populations as the infiltrate size increased. T cells formed the largest component of mononuclear cells of all aggregates. The large grade 3 aggregates contained substantial numbers of B cells arranged around a central venule and cells bearing the CD45RA+ phenotype. In contrast, the small grade 1 aggregates contained few B cells and the T-cell population contained relatively greater numbers of CD8+ cells. Cells bearing the CD45RO+ phenotype exceeded CD45RA+ cells in grade 1 aggregates. Detailed analysis of mononuclear cell aggregates of different sizes in the rheumatoid synovium suggests that the composition of each aggregate depends on the total number of mononuclear cells it contains.</description><subject>Antigens, CD - analysis</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>B-Lymphocytes - pathology</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inflammatory joint diseases</subject><subject>Leukocyte Count</subject><subject>Life Sciences & Biomedicine</subject><subject>Medical sciences</subject><subject>Rheumatology</subject><subject>Science & Technology</subject><subject>Synovial Membrane - pathology</subject><subject>T-Lymphocytes - pathology</subject><issn>0049-0172</issn><issn>1532-866X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkF1rFDEUhkNR6rb6DyrMhUiLjM3H7CS5KSxLP6QFbxSKN-FMPmhkdrImmcr--2acZb0TQyAczvOeJA9CZwR_Jpi0lxg3ssaE03NJL2SpcH1_hBZkyWgt2vbxFVockDfoJKWfGBPSYn6MjklLWyqWC3S9GqDfJZ-q4Cpt-77ahu3YQ_ZhSJUfqvhkxw3k4E0FMT9FnwubdkN49tBXpUijTW_Rawd9su_25yn6fnP9bX1XP3y9_bJePdS6ESTXIJmhRpKGCSuNMwxrR7k1vDMWU8CyY5QRwh0w2TWy0RywcJwI2QhgYNkp-jjP3cbwq9yb1can6dUw2DAmxRlecsJ4AZsZ1DGkFK1T2-g3EHeKYDXZU5MaNalRsuzJnrovsff7-WO3seZvaNZV-h_2fUgaehdh0D4dsCWTTHJcMDFjv20XXNLeDtoeqBWRkt79oFzgstq1z39sr8M45BL99P_RQl_NtC3Sn72Nap8wPlqdlQn-3x9-AW8FrSk</recordid><startdate>19920601</startdate><enddate>19920601</enddate><creator>Yanni, Ghada</creator><creator>Whelan, Alex</creator><creator>Feighery, Conleth</creator><creator>Bresnihan, Barry</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920601</creationdate><title>Analysis of cell populations in rheumatoid arthritis synovial tissues</title><author>Yanni, Ghada ; Whelan, Alex ; Feighery, Conleth ; Bresnihan, Barry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-a93d2d91438e9dfd30cf27ed7bde02a09b323117fa39b494c7a08f718948a3ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Antigens, CD - analysis</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>B-Lymphocytes - pathology</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Inflammatory joint diseases</topic><topic>Leukocyte Count</topic><topic>Life Sciences & Biomedicine</topic><topic>Medical sciences</topic><topic>Rheumatology</topic><topic>Science & Technology</topic><topic>Synovial Membrane - pathology</topic><topic>T-Lymphocytes - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yanni, Ghada</creatorcontrib><creatorcontrib>Whelan, Alex</creatorcontrib><creatorcontrib>Feighery, Conleth</creatorcontrib><creatorcontrib>Bresnihan, Barry</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yanni, Ghada</au><au>Whelan, Alex</au><au>Feighery, Conleth</au><au>Bresnihan, Barry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of cell populations in rheumatoid arthritis synovial tissues</atitle><jtitle>Seminars in arthritis and rheumatism</jtitle><stitle>SEMIN ARTHRITIS RHEU</stitle><addtitle>Semin Arthritis Rheum</addtitle><date>1992-06-01</date><risdate>1992</risdate><volume>21</volume><issue>6</issue><spage>393</spage><epage>399</epage><pages>393-399</pages><issn>0049-0172</issn><eissn>1532-866X</eissn><coden>SAHRBF</coden><abstract>Knee synovium, taken from patients with rheumatoid arthritis at the time of arthroplasty, was studied immunohistologically. 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| ispartof | Seminars in arthritis and rheumatism, 1992-06, Vol.21 (6), p.393-399 |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Antigens, CD - analysis Arthritis, Rheumatoid - pathology B-Lymphocytes - pathology Biological and medical sciences Diseases of the osteoarticular system Humans Immunohistochemistry Inflammatory joint diseases Leukocyte Count Life Sciences & Biomedicine Medical sciences Rheumatology Science & Technology Synovial Membrane - pathology T-Lymphocytes - pathology |
| title | Analysis of cell populations in rheumatoid arthritis synovial tissues |
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