Sampling time for serum gentamicin levels
A survey in 53 UK hospitals showed that 44% of clinical microbiologists recommended post-dose serum gentamicin concentrations to be measured at less than 40 min after an iv bolus dose. Serum gentamicin concentrations were measured in ten patients following bolus iv and im injections. Distribution of...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1992-05, Vol.29 (5), p.575-578 |
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| container_end_page | 578 |
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| container_issue | 5 |
| container_start_page | 575 |
| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 29 |
| creator | EDWARDS, C BINT, A. J VENABLES, C. W SCOTT, D. K |
| description | A survey in 53 UK hospitals showed that 44% of clinical microbiologists recommended post-dose serum gentamicin concentrations to be measured at less than 40 min after an iv bolus dose. Serum gentamicin concentrations were measured in ten patients following bolus iv and im injections. Distribution of the drug occurred for up to 45 min following iv doses and maximum serum concentrations occurred at 45 to 60 min after im injection. The data validate current guidelines to sample at 60 min post bolus iv and im doses. Earlier sampling after iv bolus injections may result in significantly higher gentamicin concentrations, leading to potential interpretive errors of clinical significance. |
| doi_str_mv | 10.1093/jac/29.5.575 |
| format | Article |
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Earlier sampling after iv bolus injections may result in significantly higher gentamicin concentrations, leading to potential interpretive errors of clinical significance.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/29.5.575</identifier><identifier>PMID: 1624395</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Gentamicins - administration & dosage ; Gentamicins - blood ; Humans ; Injections, Intramuscular ; Injections, Intravenous ; Medical sciences ; Microbiological Techniques ; Pharmacology. 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K</creatorcontrib><title>Sampling time for serum gentamicin levels</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>A survey in 53 UK hospitals showed that 44% of clinical microbiologists recommended post-dose serum gentamicin concentrations to be measured at less than 40 min after an iv bolus dose. Serum gentamicin concentrations were measured in ten patients following bolus iv and im injections. Distribution of the drug occurred for up to 45 min following iv doses and maximum serum concentrations occurred at 45 to 60 min after im injection. The data validate current guidelines to sample at 60 min post bolus iv and im doses. Earlier sampling after iv bolus injections may result in significantly higher gentamicin concentrations, leading to potential interpretive errors of clinical significance.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Gentamicins - administration & dosage</subject><subject>Gentamicins - blood</subject><subject>Humans</subject><subject>Injections, Intramuscular</subject><subject>Injections, Intravenous</subject><subject>Medical sciences</subject><subject>Microbiological Techniques</subject><subject>Pharmacology. 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Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Gentamicins - administration & dosage</topic><topic>Gentamicins - blood</topic><topic>Humans</topic><topic>Injections, Intramuscular</topic><topic>Injections, Intravenous</topic><topic>Medical sciences</topic><topic>Microbiological Techniques</topic><topic>Pharmacology. Drug treatments</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EDWARDS, C</creatorcontrib><creatorcontrib>BINT, A. J</creatorcontrib><creatorcontrib>VENABLES, C. W</creatorcontrib><creatorcontrib>SCOTT, D. 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Earlier sampling after iv bolus injections may result in significantly higher gentamicin concentrations, leading to potential interpretive errors of clinical significance.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>1624395</pmid><doi>10.1093/jac/29.5.575</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 1992-05, Vol.29 (5), p.575-578 |
| issn | 0305-7453 1460-2091 |
| language | eng |
| recordid | cdi_pubmed_primary_1624395 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Gentamicins - administration & dosage Gentamicins - blood Humans Injections, Intramuscular Injections, Intravenous Medical sciences Microbiological Techniques Pharmacology. Drug treatments Time Factors |
| title | Sampling time for serum gentamicin levels |
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