Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT

Immunomodulatory drugs (IMiDs) are orally available small molecules that potently inhibit tumor necrosis factor-alpha (TNF-alpha) production by lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (HuPBMCs) but enhance secretion of such cytokines as interleukin-2 (IL-2) and i...

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Veröffentlicht in:	Journal of interferon & cytokine research 2005-10, Vol.25 (10), p.604
Hauptverfasser:	Payvandi, Faribourz, Wu, Lei, Naziruddin, Syedah D, Haley, Maura, Parton, Anastasia, Schafer, Peter H, Chen, Roger S, Muller, George W, Hughes, Christopher C W, Stirling, David I
Format:	Artikel
Sprache:	eng
Schlagworte:	Dose-Response Relationship, Drug Enzyme Activation - drug effects Gene Expression Regulation - drug effects Humans Immunologic Factors - pharmacology Interleukin-2 - secretion Ionomycin - pharmacology Ionophores - pharmacology Isoenzymes - metabolism K562 Cells Killer Cells, Natural - enzymology Killer Cells, Natural - secretion Lymphocyte Activation - drug effects Protein Kinase C - metabolism Protein Kinase C-theta T-Lymphocytes - enzymology T-Lymphocytes - secretion Tetradecanoylphorbol Acetate - pharmacology Thalidomide - analogs & derivatives Thalidomide - pharmacology Transcription Factors - metabolism
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