Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons

SK channels are Ca2+-activated K+ channels that underlie after hyperpolarizing (AHP) currents and contribute to the shaping of the firing patterns and regulation of Ca2+ influx in a variety of neurons. The elucidation of SK channel function has recently benefited from the discovery of SK channel enh...

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Veröffentlicht in:	The Journal of biological chemistry 2005-12, Vol.280 (50), p.41404
Hauptverfasser:	Pedarzani, Paola, McCutcheon, Jaime E, Rogge, Gregor, Jensen, Bo Skaaning, Christophersen, Palle, Hougaard, Charlotte, Strøbaek, Dorte, Stocker, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - chemistry Calcium - metabolism Cell Line Dose-Response Relationship, Drug Electrophysiology Hippocampus - metabolism Humans KCNQ2 Potassium Channel - metabolism KCNQ3 Potassium Channel - metabolism Multienzyme Complexes - metabolism Neurons - metabolism Phosphotransferases (Alcohol Group Acceptor) - metabolism Potassium - metabolism Pyramidal Cells - metabolism Rats Rats, Sprague-Dawley Recombinant Proteins - chemistry Recombinant Proteins - metabolism Small-Conductance Calcium-Activated Potassium Channels - chemistry Small-Conductance Calcium-Activated Potassium Channels - physiology Sulfate Adenylyltransferase - metabolism Synaptic Transmission Time Factors
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