Low Mobility of Phosphatidylinositol 4,5-Bisphosphate Underlies Receptor Specificity of Gq-Mediated Ion Channel Regulation in Atrial Myocytes

We have shown previously that cardiac G protein-gated inwardly rectifying K+(GIRK) channels are inhibited by Gq protein-coupled receptors (GqPCRs) via phosphatidylinositol 4,5-bisphosphate (PIP2) depletion in a receptor-specific manner. To investigate the mechanism of receptor specificity, we examin...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-10, Vol.102 (42), p.15241-15246
Hauptverfasser:	Cho, Hana, Yeon A. Kim, Jin-Young Yoon, Lee, Doyun, Kim, Jae Ho, Lee, Suk Ho, Ho, Won-Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagonist drugs Biological Sciences Bleaching Cell membranes Cellular biology Cytochalasins Dyes Endothelin-1 - metabolism Fluorescence Fluorescence Recovery After Photobleaching Fluorescent Dyes - metabolism GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism Heart Atria - cytology Kinetics Membranes Mice Models, Molecular Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Neurons Patch-Clamp Techniques Phosphatidylinositol 4,5-Diphosphate - metabolism Phosphatidylinositols Phospholipids - chemistry Phospholipids - metabolism Pipettes Proteins Receptors Receptors, G-Protein-Coupled - metabolism Signal transduction
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