Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: oligozoospermia
Recently, intracytoplasmic sperm injection (ICSI) has been extremely successful for the treatment of male infertility. However, transmission of cytogenetic defects to offspring is a great concern. There are two types of cytogenetic problems in patients seeking ICSI; one is the transmission of geneti...
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| description | Recently, intracytoplasmic sperm injection (ICSI) has been extremely successful for the treatment of male infertility. However, transmission of cytogenetic defects to offspring is a great concern. There are two types of cytogenetic problems in patients seeking ICSI; one is the transmission of genetic defects from patients with constitutional chromosomal abnormalities and the second is the generation of de novo defects in infertile men. Generally about 5.1% of infertile men have chromosomal abnormalities. Among such infertile men, men with severe spermatogenesis defects, including oligozoospermia and azoospermia, are subjects for ICSI. Therefore it is very important to obtain cytogenetic information in these infertile patients. Furthermore, oligozoospermic men with a normal somatic karyotype also have increased frequencies of sperm chromosome abnormalities. Oligozoospermia is usually associated with other sperm alterations, for example oligoasthenozoospermia, oligoteratozoospemia and oligoasthenoteratozoospermia. In this review, the relationship between sperm concentration and sperm aneuploidy frequencies has been analyzed. The inverse correlation between the frequency of sperm aneuploidy and concentration has been reported in extensive studies. Especially in severe oligozoospermia, a significantly higher frequency of sex chromosome aneuploidy has been observed and this has been corroborated in recent clinical outcome data of ICSI. |
| doi_str_mv | 10.1159/000086909 |
| format | Article |
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However, transmission of cytogenetic defects to offspring is a great concern. There are two types of cytogenetic problems in patients seeking ICSI; one is the transmission of genetic defects from patients with constitutional chromosomal abnormalities and the second is the generation of de novo defects in infertile men. Generally about 5.1% of infertile men have chromosomal abnormalities. Among such infertile men, men with severe spermatogenesis defects, including oligozoospermia and azoospermia, are subjects for ICSI. Therefore it is very important to obtain cytogenetic information in these infertile patients. Furthermore, oligozoospermic men with a normal somatic karyotype also have increased frequencies of sperm chromosome abnormalities. Oligozoospermia is usually associated with other sperm alterations, for example oligoasthenozoospermia, oligoteratozoospemia and oligoasthenoteratozoospermia. In this review, the relationship between sperm concentration and sperm aneuploidy frequencies has been analyzed. The inverse correlation between the frequency of sperm aneuploidy and concentration has been reported in extensive studies. Especially in severe oligozoospermia, a significantly higher frequency of sex chromosome aneuploidy has been observed and this has been corroborated in recent clinical outcome data of ICSI. </description><identifier>ISSN: 1424-8581</identifier><identifier>ISBN: 3805580061</identifier><identifier>ISBN: 9783805580069</identifier><identifier>EISSN: 1424-859X</identifier><identifier>EISBN: 3318012718</identifier><identifier>EISBN: 9783318012712</identifier><identifier>DOI: 10.1159/000086909</identifier><identifier>PMID: 16192714</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Chromosome Aberrations ; Humans ; In Situ Hybridization, Fluorescence ; Infertility and Chromosome Abnormalities in Human Gametes ; Infertility, Male - genetics ; Karyotyping ; Male ; Oligospermia - genetics ; Semen - physiology ; Sperm Motility</subject><ispartof>Cytogenetic and genome research, 2005-01, Vol.111 (3-4), p.347-351</ispartof><rights>2005 S. Karger AG, Basel</rights><rights>Copyright 2005 S. Karger AG, Basel.</rights><rights>Copyright (c) 2005 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-a0ff7063e7e2c0ecfac9ede5a70049173717e156389070477bdfa52ae91e33733</citedby><cites>FETCH-LOGICAL-c450t-a0ff7063e7e2c0ecfac9ede5a70049173717e156389070477bdfa52ae91e33733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16192714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miharu, N.</creatorcontrib><title>Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: oligozoospermia</title><title>Cytogenetic and genome research</title><addtitle>Cytogenet Genome Res</addtitle><description>Recently, intracytoplasmic sperm injection (ICSI) has been extremely successful for the treatment of male infertility. 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In this review, the relationship between sperm concentration and sperm aneuploidy frequencies has been analyzed. The inverse correlation between the frequency of sperm aneuploidy and concentration has been reported in extensive studies. 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genetics</topic><topic>Karyotyping</topic><topic>Male</topic><topic>Oligospermia - genetics</topic><topic>Semen - physiology</topic><topic>Sperm Motility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miharu, N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Cytogenetic and genome research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miharu, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: oligozoospermia</atitle><jtitle>Cytogenetic and genome research</jtitle><addtitle>Cytogenet Genome Res</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>111</volume><issue>3-4</issue><spage>347</spage><epage>351</epage><pages>347-351</pages><issn>1424-8581</issn><eissn>1424-859X</eissn><isbn>3805580061</isbn><isbn>9783805580069</isbn><eisbn>3318012718</eisbn><eisbn>9783318012712</eisbn><abstract>Recently, intracytoplasmic sperm injection (ICSI) has been extremely successful for the treatment of male infertility. However, transmission of cytogenetic defects to offspring is a great concern. There are two types of cytogenetic problems in patients seeking ICSI; one is the transmission of genetic defects from patients with constitutional chromosomal abnormalities and the second is the generation of de novo defects in infertile men. Generally about 5.1% of infertile men have chromosomal abnormalities. Among such infertile men, men with severe spermatogenesis defects, including oligozoospermia and azoospermia, are subjects for ICSI. Therefore it is very important to obtain cytogenetic information in these infertile patients. Furthermore, oligozoospermic men with a normal somatic karyotype also have increased frequencies of sperm chromosome abnormalities. Oligozoospermia is usually associated with other sperm alterations, for example oligoasthenozoospermia, oligoteratozoospemia and oligoasthenoteratozoospermia. In this review, the relationship between sperm concentration and sperm aneuploidy frequencies has been analyzed. The inverse correlation between the frequency of sperm aneuploidy and concentration has been reported in extensive studies. Especially in severe oligozoospermia, a significantly higher frequency of sex chromosome aneuploidy has been observed and this has been corroborated in recent clinical outcome data of ICSI. </abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>16192714</pmid><doi>10.1159/000086909</doi><tpages>5</tpages></addata></record> |
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| ispartof | Cytogenetic and genome research, 2005-01, Vol.111 (3-4), p.347-351 |
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| source | MEDLINE; Karger Journals Complete; Alma/SFX Local Collection |
| subjects | Chromosome Aberrations Humans In Situ Hybridization, Fluorescence Infertility and Chromosome Abnormalities in Human Gametes Infertility, Male - genetics Karyotyping Male Oligospermia - genetics Semen - physiology Sperm Motility |
| title | Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: oligozoospermia |
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