A Plausible Model for the Digital Response of p53 to DNA Damage

Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is "digital" in that it is the number of oscillations rather than the amplitude of p53 that shows dependence on the radiation dose. We present a model of this phenomenon. In our model, double-strand br...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-10, Vol.102 (40), p.14266-14271
Hauptverfasser:	Ma, Lan, Wagner, John, Rice, John Jeremy, Hu, Wenwei, Levine, Arnold J., Stolovitzky, Gustavo A., Austin, Robert H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins Biological Sciences Cell cycle Cell Cycle Proteins - metabolism Cell lines Computer Simulation Control loops DNA Damage DNA repair DNA Repair - physiology DNA-Binding Proteins - metabolism Feedback, Physiological - physiology Genes Mathematical models Modeling Models, Biological Monomers Oscillation Oscillators Protein-Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins c-mdm2 - metabolism Radiation, Ionizing Signal Transduction - physiology Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!