Targeted therapy in renal cell carcinoma

Hypoxia-regulated genes such as vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) are both important for tumour progression in renal cell carcinoma (RCC). Drugs that block these and other pathways have been examined in Phase I and II clinical trials in patients with advance...

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Veröffentlicht in:	Expert opinion on investigational drugs 2005-10, Vol.14 (10), p.1251-1258
Hauptverfasser:	Favaro, Justin P, George, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage bevacizumab Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - metabolism Drug Delivery Systems - methods epidermal growth factor epidermal growth factor receptor erlotinib Humans Kidney Neoplasms - drug therapy Kidney Neoplasms - metabolism mTOR rapamycin renal cell carcinoma Signal Transduction - drug effects Signal Transduction - physiology tyrosine kinase inhibitor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism VEGF VEGFR
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