A single aromatic amino acid at the carboxyl terminus of Helicobacter pylori {alpha}1,3/4 fucosyltransferase determines substrate specificity

Fucosyltransferases (FucT) from different Helicobacter pylori strains display distinct Type I (Galbeta1,3GlcNAc) or Type II (Galbeta1,4GlcNAc) substrate specificity. FucT from strain UA948 can transfer fucose to the OH-3 of Type II acceptors as well as to the OH-4 of Type I acceptors on the GlcNAc m...

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Veröffentlicht in:	The Journal of biological chemistry 2005-11, Vol.280 (44), p.36848
Hauptverfasser:	Ma, Bing, Lau, Leon H, Palcic, Monica M, Hazes, Bart, Taylor, Diane E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution DNA Primers - chemistry Fucosyltransferases - genetics Fucosyltransferases - metabolism Helicobacter pylori - enzymology Molecular Sequence Data Mutagenesis, Site-Directed Protein Structure, Tertiary Sequence Homology, Amino Acid Substrate Specificity Tyrosine - chemistry Tyrosine - genetics
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