Effective local control of prostate cancer by intratumoral injection of (166)Ho-chitosan complex (DW-166HC) in rats
The aim of this study was to evaluate the therapeutic effect and morphological alterations resulting from (166)Ho-chitosan complex (DW-166HC) in an animal model of prostate cancer. First, in a subcutaneous tumor model, 80 rats were randomly divided into four groups (n=20 in each group), and intratum...
Gespeichert in:
| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2005-12, Vol.32 (12), p.1400 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 12 |
| container_start_page | 1400 |
| container_title | European journal of nuclear medicine and molecular imaging |
| container_volume | 32 |
| creator | Kwak, Cheol Hong, Sung Kyu Seong, Seung Kyoo Ryu, Jei Man Park, Moon Soo Lee, Sang Eun |
| description | The aim of this study was to evaluate the therapeutic effect and morphological alterations resulting from (166)Ho-chitosan complex (DW-166HC) in an animal model of prostate cancer.
First, in a subcutaneous tumor model, 80 rats were randomly divided into four groups (n=20 in each group), and intratumoral injections of 0.05 ml (normal saline in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (10 mCi) in group 3, and DW-166HC solution (20 mCi) in group 4) were performed when the tumor measured approximately 1 cm along its long axis in each group. Further, in an orthotopic tumor model, 40 rats were similarly randomly divided into four groups (n=10 in each group), and intraprostatic injections of 0.05 ml [PBS in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (0.5 mCi) in group 3 and DW-166HC solution (1 mCi) in group 4] were performed at 1 week after implantation of the AIT cell line in the ventral prostate.
In the subcutaneous tumor model, mean tumor weights of groups 3 and 4 were significantly lower than those of groups 1 and 2 at 2 and 4 weeks post injection (p |
| doi_str_mv | 10.1007/s00259-005-1892-y |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_16133378</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16133378</sourcerecordid><originalsourceid>FETCH-LOGICAL-p124t-dda3def344f717850fdc8231017def409aaae9fc652bcde706a8faa9d0e0d39a3</originalsourceid><addsrcrecordid>eNo1jz1PwzAURT2AaCn8ABbksR0Mz3ES2yMqhSJVYgExVq_-EKmSOIpdRP89roDpSffcc6VHyA2HOw4g7yNAUWkGUDGudMGOZ2TKa66ZBAkTchnjHoCrQukLMslACCHVlMSV986k5svRNhhsqQl9GkNLg6fDGGLC5KjB3riR7o60yRDToQtjrjb9_qSG_lSe87perAMzn00KEfs81A2t-6bzxw-W2Xq5yALNdrwi5x7b6K7_7oy8P63elmu2eX1-WT5s2MCLMjFrUVjnRVl6yaWqwFujCsGByxyXoBHRaW_qqtgZ6yTUqDyituDACo1iRm5_d4fDrnN2O4xNh-Nx-_-9-AEqX1u6</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effective local control of prostate cancer by intratumoral injection of (166)Ho-chitosan complex (DW-166HC) in rats</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kwak, Cheol ; Hong, Sung Kyu ; Seong, Seung Kyoo ; Ryu, Jei Man ; Park, Moon Soo ; Lee, Sang Eun</creator><creatorcontrib>Kwak, Cheol ; Hong, Sung Kyu ; Seong, Seung Kyoo ; Ryu, Jei Man ; Park, Moon Soo ; Lee, Sang Eun</creatorcontrib><description>The aim of this study was to evaluate the therapeutic effect and morphological alterations resulting from (166)Ho-chitosan complex (DW-166HC) in an animal model of prostate cancer.
First, in a subcutaneous tumor model, 80 rats were randomly divided into four groups (n=20 in each group), and intratumoral injections of 0.05 ml (normal saline in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (10 mCi) in group 3, and DW-166HC solution (20 mCi) in group 4) were performed when the tumor measured approximately 1 cm along its long axis in each group. Further, in an orthotopic tumor model, 40 rats were similarly randomly divided into four groups (n=10 in each group), and intraprostatic injections of 0.05 ml [PBS in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (0.5 mCi) in group 3 and DW-166HC solution (1 mCi) in group 4] were performed at 1 week after implantation of the AIT cell line in the ventral prostate.
In the subcutaneous tumor model, mean tumor weights of groups 3 and 4 were significantly lower than those of groups 1 and 2 at 2 and 4 weeks post injection (p<0.05). At 2 and 4 weeks after injection in the orthotopic tumor model, the mean weights of the prostate, including tumor, in groups 3 and 4 were also significantly lower than those in groups 1 and 2 (p<0.05). No adverse injury was seen in adjacent organs at histopathologic examination.
Intratumoral injection of the beta-emitting radionuclide (166)Ho as a form of complex solution with chitosan appears to be a promising alternative therapeutic modality for the local control of prostate cancer.</description><identifier>ISSN: 1619-7070</identifier><identifier>DOI: 10.1007/s00259-005-1892-y</identifier><identifier>PMID: 16133378</identifier><language>eng</language><publisher>Germany</publisher><subject><![CDATA[Animals ; Body Weight - radiation effects ; Chitin - administration & dosage ; Chitin - adverse effects ; Chitin - analogs & derivatives ; Holmium - administration & dosage ; Holmium - adverse effects ; Injections, Intralesional - methods ; Male ; Organometallic Compounds - administration & dosage ; Organometallic Compounds - adverse effects ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - radiotherapy ; Radioisotopes - administration & dosage ; Radioisotopes - adverse effects ; Radiopharmaceuticals - administration & dosage ; Radiopharmaceuticals - adverse effects ; Rats ; Survival Rate ; Treatment Outcome]]></subject><ispartof>European journal of nuclear medicine and molecular imaging, 2005-12, Vol.32 (12), p.1400</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16133378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwak, Cheol</creatorcontrib><creatorcontrib>Hong, Sung Kyu</creatorcontrib><creatorcontrib>Seong, Seung Kyoo</creatorcontrib><creatorcontrib>Ryu, Jei Man</creatorcontrib><creatorcontrib>Park, Moon Soo</creatorcontrib><creatorcontrib>Lee, Sang Eun</creatorcontrib><title>Effective local control of prostate cancer by intratumoral injection of (166)Ho-chitosan complex (DW-166HC) in rats</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>The aim of this study was to evaluate the therapeutic effect and morphological alterations resulting from (166)Ho-chitosan complex (DW-166HC) in an animal model of prostate cancer.
First, in a subcutaneous tumor model, 80 rats were randomly divided into four groups (n=20 in each group), and intratumoral injections of 0.05 ml (normal saline in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (10 mCi) in group 3, and DW-166HC solution (20 mCi) in group 4) were performed when the tumor measured approximately 1 cm along its long axis in each group. Further, in an orthotopic tumor model, 40 rats were similarly randomly divided into four groups (n=10 in each group), and intraprostatic injections of 0.05 ml [PBS in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (0.5 mCi) in group 3 and DW-166HC solution (1 mCi) in group 4] were performed at 1 week after implantation of the AIT cell line in the ventral prostate.
In the subcutaneous tumor model, mean tumor weights of groups 3 and 4 were significantly lower than those of groups 1 and 2 at 2 and 4 weeks post injection (p<0.05). At 2 and 4 weeks after injection in the orthotopic tumor model, the mean weights of the prostate, including tumor, in groups 3 and 4 were also significantly lower than those in groups 1 and 2 (p<0.05). No adverse injury was seen in adjacent organs at histopathologic examination.
Intratumoral injection of the beta-emitting radionuclide (166)Ho as a form of complex solution with chitosan appears to be a promising alternative therapeutic modality for the local control of prostate cancer.</description><subject>Animals</subject><subject>Body Weight - radiation effects</subject><subject>Chitin - administration & dosage</subject><subject>Chitin - adverse effects</subject><subject>Chitin - analogs & derivatives</subject><subject>Holmium - administration & dosage</subject><subject>Holmium - adverse effects</subject><subject>Injections, Intralesional - methods</subject><subject>Male</subject><subject>Organometallic Compounds - administration & dosage</subject><subject>Organometallic Compounds - adverse effects</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Radioisotopes - administration & dosage</subject><subject>Radioisotopes - adverse effects</subject><subject>Radiopharmaceuticals - administration & dosage</subject><subject>Radiopharmaceuticals - adverse effects</subject><subject>Rats</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>1619-7070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1jz1PwzAURT2AaCn8ABbksR0Mz3ES2yMqhSJVYgExVq_-EKmSOIpdRP89roDpSffcc6VHyA2HOw4g7yNAUWkGUDGudMGOZ2TKa66ZBAkTchnjHoCrQukLMslACCHVlMSV986k5svRNhhsqQl9GkNLg6fDGGLC5KjB3riR7o60yRDToQtjrjb9_qSG_lSe87perAMzn00KEfs81A2t-6bzxw-W2Xq5yALNdrwi5x7b6K7_7oy8P63elmu2eX1-WT5s2MCLMjFrUVjnRVl6yaWqwFujCsGByxyXoBHRaW_qqtgZ6yTUqDyituDACo1iRm5_d4fDrnN2O4xNh-Nx-_-9-AEqX1u6</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Kwak, Cheol</creator><creator>Hong, Sung Kyu</creator><creator>Seong, Seung Kyoo</creator><creator>Ryu, Jei Man</creator><creator>Park, Moon Soo</creator><creator>Lee, Sang Eun</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200512</creationdate><title>Effective local control of prostate cancer by intratumoral injection of (166)Ho-chitosan complex (DW-166HC) in rats</title><author>Kwak, Cheol ; Hong, Sung Kyu ; Seong, Seung Kyoo ; Ryu, Jei Man ; Park, Moon Soo ; Lee, Sang Eun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-dda3def344f717850fdc8231017def409aaae9fc652bcde706a8faa9d0e0d39a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Body Weight - radiation effects</topic><topic>Chitin - administration & dosage</topic><topic>Chitin - adverse effects</topic><topic>Chitin - analogs & derivatives</topic><topic>Holmium - administration & dosage</topic><topic>Holmium - adverse effects</topic><topic>Injections, Intralesional - methods</topic><topic>Male</topic><topic>Organometallic Compounds - administration & dosage</topic><topic>Organometallic Compounds - adverse effects</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>Radioisotopes - administration & dosage</topic><topic>Radioisotopes - adverse effects</topic><topic>Radiopharmaceuticals - administration & dosage</topic><topic>Radiopharmaceuticals - adverse effects</topic><topic>Rats</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwak, Cheol</creatorcontrib><creatorcontrib>Hong, Sung Kyu</creatorcontrib><creatorcontrib>Seong, Seung Kyoo</creatorcontrib><creatorcontrib>Ryu, Jei Man</creatorcontrib><creatorcontrib>Park, Moon Soo</creatorcontrib><creatorcontrib>Lee, Sang Eun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwak, Cheol</au><au>Hong, Sung Kyu</au><au>Seong, Seung Kyoo</au><au>Ryu, Jei Man</au><au>Park, Moon Soo</au><au>Lee, Sang Eun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effective local control of prostate cancer by intratumoral injection of (166)Ho-chitosan complex (DW-166HC) in rats</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2005-12</date><risdate>2005</risdate><volume>32</volume><issue>12</issue><spage>1400</spage><pages>1400-</pages><issn>1619-7070</issn><abstract>The aim of this study was to evaluate the therapeutic effect and morphological alterations resulting from (166)Ho-chitosan complex (DW-166HC) in an animal model of prostate cancer.
First, in a subcutaneous tumor model, 80 rats were randomly divided into four groups (n=20 in each group), and intratumoral injections of 0.05 ml (normal saline in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (10 mCi) in group 3, and DW-166HC solution (20 mCi) in group 4) were performed when the tumor measured approximately 1 cm along its long axis in each group. Further, in an orthotopic tumor model, 40 rats were similarly randomly divided into four groups (n=10 in each group), and intraprostatic injections of 0.05 ml [PBS in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (0.5 mCi) in group 3 and DW-166HC solution (1 mCi) in group 4] were performed at 1 week after implantation of the AIT cell line in the ventral prostate.
In the subcutaneous tumor model, mean tumor weights of groups 3 and 4 were significantly lower than those of groups 1 and 2 at 2 and 4 weeks post injection (p<0.05). At 2 and 4 weeks after injection in the orthotopic tumor model, the mean weights of the prostate, including tumor, in groups 3 and 4 were also significantly lower than those in groups 1 and 2 (p<0.05). No adverse injury was seen in adjacent organs at histopathologic examination.
Intratumoral injection of the beta-emitting radionuclide (166)Ho as a form of complex solution with chitosan appears to be a promising alternative therapeutic modality for the local control of prostate cancer.</abstract><cop>Germany</cop><pmid>16133378</pmid><doi>10.1007/s00259-005-1892-y</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2005-12, Vol.32 (12), p.1400 |
| issn | 1619-7070 |
| language | eng |
| recordid | cdi_pubmed_primary_16133378 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Body Weight - radiation effects Chitin - administration & dosage Chitin - adverse effects Chitin - analogs & derivatives Holmium - administration & dosage Holmium - adverse effects Injections, Intralesional - methods Male Organometallic Compounds - administration & dosage Organometallic Compounds - adverse effects Prostatic Neoplasms - pathology Prostatic Neoplasms - radiotherapy Radioisotopes - administration & dosage Radioisotopes - adverse effects Radiopharmaceuticals - administration & dosage Radiopharmaceuticals - adverse effects Rats Survival Rate Treatment Outcome |
| title | Effective local control of prostate cancer by intratumoral injection of (166)Ho-chitosan complex (DW-166HC) in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T14%3A39%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effective%20local%20control%20of%20prostate%20cancer%20by%20intratumoral%20injection%20of%20(166)Ho-chitosan%20complex%20(DW-166HC)%20in%20rats&rft.jtitle=European%20journal%20of%20nuclear%20medicine%20and%20molecular%20imaging&rft.au=Kwak,%20Cheol&rft.date=2005-12&rft.volume=32&rft.issue=12&rft.spage=1400&rft.pages=1400-&rft.issn=1619-7070&rft_id=info:doi/10.1007/s00259-005-1892-y&rft_dat=%3Cpubmed%3E16133378%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/16133378&rfr_iscdi=true |