Biological Function of the Vaccinia Virus Z-DNA-Binding Protein E3L: Gene Transactivation and Antiapoptotic Activity in HeLa Cells

The vaccinia virus (VV) E3L protein is essential for virulence and has anti-apoptotic activity. In mice, Z-DNA-binding activity of the N-terminal domain of E3L (Zα) is necessary for viral lethality. Here, we report that inhibition of hygromycin-B-induced apoptosis in HeLa cells depends on Z-DNA bind...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-09, Vol.102 (36), p.12759-12764
Hauptverfasser:	Kwon, Jin-Ah, Rich, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 cells Apoptosis Apoptosis - drug effects Apoptosis - genetics Binding sites Biological Sciences Cell lines Cell Nucleus - genetics Cell Nucleus - metabolism Cellular biology Crystallography, X-Ray DNA, Z-Form - genetics DNA, Z-Form - metabolism DNA-Binding Proteins - genetics Gene expression Genes HeLa Cells Humans Hygromycin B - pharmacology Interleukin-6 - genetics Models, Molecular NFATC Transcription Factors Nuclear Proteins - genetics Plasmids Protein Structure, Tertiary Proteins RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism T lymphocytes Time Factors Transactivation Transcription Factors - genetics Transcriptional Activation - genetics Tumor Suppressor Protein p53 - genetics Vaccinia virus Vaccinia virus - genetics Vaccinia virus - metabolism Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism Viruses Z form DNA
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