Arabidopsis TCP20 links regulation of growth and cell division control pathways
During postembryonic plant development, cell division is coupled to cell growth. There is a stringent requirement to couple these processes in shoot and root meristems. As cells pass through meristems, they transit through zones with high rates of cell growth and proliferation during organogenesis....
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2005-09, Vol.102 (36), p.12978-12983 |
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| creator | Li, C Potuschak, T Colon-Carmona, A Gutierrez, R.A Doerner, P |
| description | During postembryonic plant development, cell division is coupled to cell growth. There is a stringent requirement to couple these processes in shoot and root meristems. As cells pass through meristems, they transit through zones with high rates of cell growth and proliferation during organogenesis. This transition implies a need for coordinate regulation of genes underpinning these two fundamental cell functions. Here, we report a mechanism for coregulation of cell division control genes and cell growth effectors. We identified a GCCCR motif necessary and sufficient for high-level cyclin CYCB1;1 expression at G2/M. This motif is overrepresented in many ribosomal protein gene promoters and is required for high-level expression of the S27 and L24 ribosomal subunit genes we examined. p33TCP20, encoded by the Arabidopsis TCP20 gene, binds to the GCCCR element in the promoters of cyclin CYCB1;1 and ribosomal protein genes in vitro and in vivo. We propose a model in which organ growth rates, and possibly shape in aerial organs, are regulated by the balance of positively and negatively acting teosinte-branched, cycloidea, PCNA factor (TCP) genes in the distal meristem boundary zone where cells become mitotically quiescent before expansion and differentiation. |
| doi_str_mv | 10.1073/pnas.0504039102 |
| format | Article |
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There is a stringent requirement to couple these processes in shoot and root meristems. As cells pass through meristems, they transit through zones with high rates of cell growth and proliferation during organogenesis. This transition implies a need for coordinate regulation of genes underpinning these two fundamental cell functions. Here, we report a mechanism for coregulation of cell division control genes and cell growth effectors. We identified a GCCCR motif necessary and sufficient for high-level cyclin CYCB1;1 expression at G2/M. This motif is overrepresented in many ribosomal protein gene promoters and is required for high-level expression of the S27 and L24 ribosomal subunit genes we examined. p33TCP20, encoded by the Arabidopsis TCP20 gene, binds to the GCCCR element in the promoters of cyclin CYCB1;1 and ribosomal protein genes in vitro and in vivo. We propose a model in which organ growth rates, and possibly shape in aerial organs, are regulated by the balance of positively and negatively acting teosinte-branched, cycloidea, PCNA factor (TCP) genes in the distal meristem boundary zone where cells become mitotically quiescent before expansion and differentiation.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0504039102</identifier><identifier>PMID: 16123132</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Arabidopsis ; Arabidopsis - cytology ; Arabidopsis - genetics ; Arabidopsis - growth & development ; Arabidopsis - metabolism ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Arabidopsis thaliana ; Base Sequence ; binding sites ; Biological Sciences ; Botany ; Cell cycle ; Cell division ; Cell Division - genetics ; Cell growth ; Cell Line ; Cyclin B - genetics ; Cyclins ; Cycloidea ; DNA Footprinting ; Gene expression ; Gene Expression Regulation, Plant - genetics ; Genes ; Growth rate ; Molecular Sequence Data ; Mutation - genetics ; nucleotide sequences ; Plant growth regulators ; Plants ; promoter regions ; Promoter Regions, Genetic - genetics ; Protein Binding ; Response Elements - genetics ; Ribosomal proteins ; Ribosomal Proteins - biosynthesis ; Ribosomal Proteins - genetics ; RNA ; Stem cells ; transcription factors</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2005-09, Vol.102 (36), p.12978-12983</ispartof><rights>Copyright 1993/2005 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Sep 6, 2005</rights><rights>Copyright © 2005, The National Academy of Sciences 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c553t-725e75e0c71d10c3f6c453b7426a16afdd5313c2b54d18cc7b200275558f3be83</citedby><cites>FETCH-LOGICAL-c553t-725e75e0c71d10c3f6c453b7426a16afdd5313c2b54d18cc7b200275558f3be83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/102/36.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3376499$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3376499$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16123132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, C</creatorcontrib><creatorcontrib>Potuschak, T</creatorcontrib><creatorcontrib>Colon-Carmona, A</creatorcontrib><creatorcontrib>Gutierrez, R.A</creatorcontrib><creatorcontrib>Doerner, P</creatorcontrib><title>Arabidopsis TCP20 links regulation of growth and cell division control pathways</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>During postembryonic plant development, cell division is coupled to cell growth. There is a stringent requirement to couple these processes in shoot and root meristems. As cells pass through meristems, they transit through zones with high rates of cell growth and proliferation during organogenesis. This transition implies a need for coordinate regulation of genes underpinning these two fundamental cell functions. Here, we report a mechanism for coregulation of cell division control genes and cell growth effectors. We identified a GCCCR motif necessary and sufficient for high-level cyclin CYCB1;1 expression at G2/M. This motif is overrepresented in many ribosomal protein gene promoters and is required for high-level expression of the S27 and L24 ribosomal subunit genes we examined. p33TCP20, encoded by the Arabidopsis TCP20 gene, binds to the GCCCR element in the promoters of cyclin CYCB1;1 and ribosomal protein genes in vitro and in vivo. We propose a model in which organ growth rates, and possibly shape in aerial organs, are regulated by the balance of positively and negatively acting teosinte-branched, cycloidea, PCNA factor (TCP) genes in the distal meristem boundary zone where cells become mitotically quiescent before expansion and differentiation.</description><subject>Arabidopsis</subject><subject>Arabidopsis - cytology</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - growth & development</subject><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Arabidopsis thaliana</subject><subject>Base Sequence</subject><subject>binding sites</subject><subject>Biological Sciences</subject><subject>Botany</subject><subject>Cell cycle</subject><subject>Cell division</subject><subject>Cell Division - genetics</subject><subject>Cell growth</subject><subject>Cell Line</subject><subject>Cyclin B - genetics</subject><subject>Cyclins</subject><subject>Cycloidea</subject><subject>DNA Footprinting</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Plant - genetics</subject><subject>Genes</subject><subject>Growth rate</subject><subject>Molecular Sequence Data</subject><subject>Mutation - genetics</subject><subject>nucleotide sequences</subject><subject>Plant growth regulators</subject><subject>Plants</subject><subject>promoter regions</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Protein Binding</subject><subject>Response Elements - genetics</subject><subject>Ribosomal proteins</subject><subject>Ribosomal Proteins - biosynthesis</subject><subject>Ribosomal Proteins - genetics</subject><subject>RNA</subject><subject>Stem cells</subject><subject>transcription factors</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktv1DAUhS0EokNhzQaBxQKJRdrrV5xskKoRL6lSkWjXluM4Mx4ycWo7Lf33OJ1RB9h05cX57tE99xih1wROCEh2Og46noAADqwmQJ-gBYGaFCWv4SlaAFBZVJzyI_Qixg0A1KKC5-iIlIQywugCXZwF3bjWj9FFfLn8QQH3bvgVcbCrqdfJ-QH7Dq-Cv01rrIcWG9v3uHU3Ls6a8UMKvsejTutbfRdfomed7qN9tX-P0dWXz5fLb8X5xdfvy7PzwgjBUiGpsFJYMJK0BAzrSsMFaySnpSal7tpW5P0MbQRvSWWMbOgcRghRdayxFTtGn3a-49RsbWtsXkP3agxuq8Od8tqpf5XBrdXK3yhybzQbfNgbBH892ZjU1sU5mx6sn6IqK1HyqoJHQVJLIiiIDL7_D9z4KQz5CooCYSXNN8_Q6Q4ywccYbPewMgE1V6rmStWh0jzx9u-kB37fYQbwHpgnD3ZUsTLHre_DfnwEUd3U98n-Tpl9s2M3MfnwADMm86-qs_xuJ3faK70KLqqrn3M-ICA4l4T9AQnjx28</recordid><startdate>20050906</startdate><enddate>20050906</enddate><creator>Li, C</creator><creator>Potuschak, T</creator><creator>Colon-Carmona, A</creator><creator>Gutierrez, R.A</creator><creator>Doerner, P</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20050906</creationdate><title>Arabidopsis TCP20 links regulation of growth and cell division control pathways</title><author>Li, C ; Potuschak, T ; Colon-Carmona, A ; Gutierrez, R.A ; Doerner, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-725e75e0c71d10c3f6c453b7426a16afdd5313c2b54d18cc7b200275558f3be83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Arabidopsis</topic><topic>Arabidopsis - cytology</topic><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - growth & development</topic><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Arabidopsis thaliana</topic><topic>Base Sequence</topic><topic>binding sites</topic><topic>Biological Sciences</topic><topic>Botany</topic><topic>Cell cycle</topic><topic>Cell division</topic><topic>Cell Division - genetics</topic><topic>Cell growth</topic><topic>Cell Line</topic><topic>Cyclin B - genetics</topic><topic>Cyclins</topic><topic>Cycloidea</topic><topic>DNA Footprinting</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Plant - genetics</topic><topic>Genes</topic><topic>Growth rate</topic><topic>Molecular Sequence Data</topic><topic>Mutation - genetics</topic><topic>nucleotide sequences</topic><topic>Plant growth regulators</topic><topic>Plants</topic><topic>promoter regions</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Protein Binding</topic><topic>Response Elements - genetics</topic><topic>Ribosomal proteins</topic><topic>Ribosomal Proteins - biosynthesis</topic><topic>Ribosomal Proteins - genetics</topic><topic>RNA</topic><topic>Stem cells</topic><topic>transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, C</creatorcontrib><creatorcontrib>Potuschak, T</creatorcontrib><creatorcontrib>Colon-Carmona, A</creatorcontrib><creatorcontrib>Gutierrez, R.A</creatorcontrib><creatorcontrib>Doerner, P</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, C</au><au>Potuschak, T</au><au>Colon-Carmona, A</au><au>Gutierrez, R.A</au><au>Doerner, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arabidopsis TCP20 links regulation of growth and cell division control pathways</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2005-09-06</date><risdate>2005</risdate><volume>102</volume><issue>36</issue><spage>12978</spage><epage>12983</epage><pages>12978-12983</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>During postembryonic plant development, cell division is coupled to cell growth. There is a stringent requirement to couple these processes in shoot and root meristems. As cells pass through meristems, they transit through zones with high rates of cell growth and proliferation during organogenesis. This transition implies a need for coordinate regulation of genes underpinning these two fundamental cell functions. Here, we report a mechanism for coregulation of cell division control genes and cell growth effectors. We identified a GCCCR motif necessary and sufficient for high-level cyclin CYCB1;1 expression at G2/M. This motif is overrepresented in many ribosomal protein gene promoters and is required for high-level expression of the S27 and L24 ribosomal subunit genes we examined. p33TCP20, encoded by the Arabidopsis TCP20 gene, binds to the GCCCR element in the promoters of cyclin CYCB1;1 and ribosomal protein genes in vitro and in vivo. We propose a model in which organ growth rates, and possibly shape in aerial organs, are regulated by the balance of positively and negatively acting teosinte-branched, cycloidea, PCNA factor (TCP) genes in the distal meristem boundary zone where cells become mitotically quiescent before expansion and differentiation.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>16123132</pmid><doi>10.1073/pnas.0504039102</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Arabidopsis Arabidopsis - cytology Arabidopsis - genetics Arabidopsis - growth & development Arabidopsis - metabolism Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Arabidopsis thaliana Base Sequence binding sites Biological Sciences Botany Cell cycle Cell division Cell Division - genetics Cell growth Cell Line Cyclin B - genetics Cyclins Cycloidea DNA Footprinting Gene expression Gene Expression Regulation, Plant - genetics Genes Growth rate Molecular Sequence Data Mutation - genetics nucleotide sequences Plant growth regulators Plants promoter regions Promoter Regions, Genetic - genetics Protein Binding Response Elements - genetics Ribosomal proteins Ribosomal Proteins - biosynthesis Ribosomal Proteins - genetics RNA Stem cells transcription factors |
| title | Arabidopsis TCP20 links regulation of growth and cell division control pathways |
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