Feeding Deterrent Effects of Catnip Oil Components Compared with Two Synthetic Amides Against Aedes aegypti
Recently, catnip, Nepeta cataria L. (Lamiaceae), essential oil has been formulated and marketed as an alternative repellent for protection against biting arthropods by several vendors. We isolated the major active components of catnip oil, E,Z- and Z,E-nepetalactone, and quantitatively measured thei...
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| Veröffentlicht in: | Journal of medical entomology 2005-07, Vol.42 (4), p.643-646 |
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| creator | Chauhan, Kamlesh R. Klun, Jerome A. Debboun, Mustapha Kramer, Matthew |
| description | Recently, catnip, Nepeta cataria L. (Lamiaceae), essential oil has been formulated and marketed as an alternative repellent for protection against biting arthropods by several vendors. We isolated the major active components of catnip oil, E,Z- and Z,E-nepetalactone, and quantitatively measured their antibiting efficacy compared with the repellents N,N-diethyl-3-methylbenzamide (deet) and chiral (1S,2′S)-2-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS220) against the yellowfever mosquito, Aedes aegypti (L.), by using an in vitro assay and human volunteers at 24 nmol compound/cm2 (cloth or skin). Of all compounds tested in an in vitro assay, SS220 ranked as the most effective, whereas catnip oil and the nepetalactone compounds did not differ significantly from each other or from deet. However, in human volunteer bioassays, neither E,Z and Z,E-nepetalactone nor racemic nepetalactone deterred mosquito biting as effectively as SS220 or deet. All compounds differed significantly from the control. We conclude that catnip oil and nepetalactone isomers are significantly less effective than deet or SS220 in deterring the biting of Ae. aegypti. |
| doi_str_mv | 10.1603/0022-2585%282005%29042%5B0643%3AFDEOCO%5D2.0.CO%3B2 |
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(Lamiaceae), essential oil has been formulated and marketed as an alternative repellent for protection against biting arthropods by several vendors. We isolated the major active components of catnip oil, E,Z- and Z,E-nepetalactone, and quantitatively measured their antibiting efficacy compared with the repellents N,N-diethyl-3-methylbenzamide (deet) and chiral (1S,2′S)-2-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS220) against the yellowfever mosquito, Aedes aegypti (L.), by using an in vitro assay and human volunteers at 24 nmol compound/cm2 (cloth or skin). Of all compounds tested in an in vitro assay, SS220 ranked as the most effective, whereas catnip oil and the nepetalactone compounds did not differ significantly from each other or from deet. However, in human volunteer bioassays, neither E,Z and Z,E-nepetalactone nor racemic nepetalactone deterred mosquito biting as effectively as SS220 or deet. All compounds differed significantly from the control. We conclude that catnip oil and nepetalactone isomers are significantly less effective than deet or SS220 in deterring the biting of Ae. aegypti.</description><identifier>ISSN: 0022-2585</identifier><identifier>EISSN: 1938-2928</identifier><identifier>DOI: 10.1603/0022-2585%282005%29042%5B0643%3AFDEOCO%5D2.0.CO%3B2</identifier><identifier>PMID: 16119554</identifier><identifier>CODEN: JMENA6</identifier><language>eng</language><publisher>Lanham, MD: Entomological Society of America</publisher><subject><![CDATA[Aedes - physiology ; Aedes aegypti ; amides ; Animals ; antifeeding activity ; bioassays ; Biological and medical sciences ; biting rates ; Cyclohexenes ; Cyclopentanes - administration & dosage ; deet ; DEET - administration & dosage ; essential oils ; Fundamental and applied biological sciences. Psychology ; Humans ; Insect Bites and Stings - prevention & control ; insect repellents ; Insect Repellents - administration & dosage ; isomers ; lactones ; Medically important nuisances and vectors, pests of stored products and materials: population survey and control ; mosquito bites ; mosquito control ; Nepeta - chemistry ; Nepeta cataria ; nepetalactone ; Piperidines - administration & dosage ; Plant Oils - chemistry ; Pyrones - administration & dosage ; repellency ; repellents ; SS220 ; VECTOR CONTROL, PEST MANAGEMENT, RESISTANCE, REPELLENTS ; Vectors. Intermediate hosts ; yellowfever mosquito]]></subject><ispartof>Journal of medical entomology, 2005-07, Vol.42 (4), p.643-646</ispartof><rights>Entomological Society of America</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.1603/0022-2585%282005%29042%5B0643%3AFDEOCO%5D2.0.CO%3B2$$EPDF$$P50$$Gbioone$$H</linktopdf><link.rule.ids>314,776,780,26955,27901,27902,52338</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16948001$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16119554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chauhan, Kamlesh R.</creatorcontrib><creatorcontrib>Klun, Jerome A.</creatorcontrib><creatorcontrib>Debboun, Mustapha</creatorcontrib><creatorcontrib>Kramer, Matthew</creatorcontrib><title>Feeding Deterrent Effects of Catnip Oil Components Compared with Two Synthetic Amides Against Aedes aegypti</title><title>Journal of medical entomology</title><addtitle>J Med Entomol</addtitle><description>Recently, catnip, Nepeta cataria L. (Lamiaceae), essential oil has been formulated and marketed as an alternative repellent for protection against biting arthropods by several vendors. We isolated the major active components of catnip oil, E,Z- and Z,E-nepetalactone, and quantitatively measured their antibiting efficacy compared with the repellents N,N-diethyl-3-methylbenzamide (deet) and chiral (1S,2′S)-2-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS220) against the yellowfever mosquito, Aedes aegypti (L.), by using an in vitro assay and human volunteers at 24 nmol compound/cm2 (cloth or skin). Of all compounds tested in an in vitro assay, SS220 ranked as the most effective, whereas catnip oil and the nepetalactone compounds did not differ significantly from each other or from deet. However, in human volunteer bioassays, neither E,Z and Z,E-nepetalactone nor racemic nepetalactone deterred mosquito biting as effectively as SS220 or deet. All compounds differed significantly from the control. We conclude that catnip oil and nepetalactone isomers are significantly less effective than deet or SS220 in deterring the biting of Ae. aegypti.</description><subject>Aedes - physiology</subject><subject>Aedes aegypti</subject><subject>amides</subject><subject>Animals</subject><subject>antifeeding activity</subject><subject>bioassays</subject><subject>Biological and medical sciences</subject><subject>biting rates</subject><subject>Cyclohexenes</subject><subject>Cyclopentanes - administration & dosage</subject><subject>deet</subject><subject>DEET - administration & dosage</subject><subject>essential oils</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Insect Bites and Stings - prevention & control</subject><subject>insect repellents</subject><subject>Insect Repellents - administration & dosage</subject><subject>isomers</subject><subject>lactones</subject><subject>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</subject><subject>mosquito bites</subject><subject>mosquito control</subject><subject>Nepeta - chemistry</subject><subject>Nepeta cataria</subject><subject>nepetalactone</subject><subject>Piperidines - administration & dosage</subject><subject>Plant Oils - chemistry</subject><subject>Pyrones - administration & dosage</subject><subject>repellency</subject><subject>repellents</subject><subject>SS220</subject><subject>VECTOR CONTROL, PEST MANAGEMENT, RESISTANCE, REPELLENTS</subject><subject>Vectors. Intermediate hosts</subject><subject>yellowfever mosquito</subject><issn>0022-2585</issn><issn>1938-2928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkVFP2zAQx60JNDrYVxh-yWPK2Y5bWzyFtB1ISBUCni0ntotHm0SxJ9RvP4fAtqf7W_fTnc4_hK4JzMkC2BUApTnlgmdUUIBUJBQ04zewKFjGys1qva22GV_ROcxTYDf0C5oRyUROJRUnaPZ3whn6FsIvABCkkF_RGVkQIjkvZuh1Y63x7Q6vbLTDYNuI187ZJgbcOVzp2Poeb_0eV92h79rUD-9RD9bgNx9f8NNbhx-PbXyx0Te4PHhjAy532rch4tKOL213xz76C3Tq9D7Y7x_1HD1v1k_VbX6__XlXlfd5TTmNuTOakNosay6WojFS17ombsk45YTXAmBJCNAFcdZoRhwXoAtpmBFGFgUVnJ2jH9Pc_nd9sEb1gz_o4ag-r05A9gHo0Oi9G3Tb-PAfJ4u0hiTucuKc7pTeDYl5fqSpASSZoDCuepiI2nfpd_6NADU6VKMBNRpQk0P17lBNDtWnQ5UcKlApJIfsD170jhE</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Chauhan, Kamlesh R.</creator><creator>Klun, Jerome A.</creator><creator>Debboun, Mustapha</creator><creator>Kramer, Matthew</creator><general>Entomological Society of America</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200507</creationdate><title>Feeding Deterrent Effects of Catnip Oil Components Compared with Two Synthetic Amides Against Aedes aegypti</title><author>Chauhan, Kamlesh R. ; Klun, Jerome A. ; Debboun, Mustapha ; Kramer, Matthew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b252t-fda11bd7b5878cd9abab1f7352515b8007110261feda31f580a49d3d8d9442853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aedes - physiology</topic><topic>Aedes aegypti</topic><topic>amides</topic><topic>Animals</topic><topic>antifeeding activity</topic><topic>bioassays</topic><topic>Biological and medical sciences</topic><topic>biting rates</topic><topic>Cyclohexenes</topic><topic>Cyclopentanes - administration & dosage</topic><topic>deet</topic><topic>DEET - administration & dosage</topic><topic>essential oils</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Insect Bites and Stings - prevention & control</topic><topic>insect repellents</topic><topic>Insect Repellents - administration & dosage</topic><topic>isomers</topic><topic>lactones</topic><topic>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</topic><topic>mosquito bites</topic><topic>mosquito control</topic><topic>Nepeta - chemistry</topic><topic>Nepeta cataria</topic><topic>nepetalactone</topic><topic>Piperidines - administration & dosage</topic><topic>Plant Oils - chemistry</topic><topic>Pyrones - administration & dosage</topic><topic>repellency</topic><topic>repellents</topic><topic>SS220</topic><topic>VECTOR CONTROL, PEST MANAGEMENT, RESISTANCE, REPELLENTS</topic><topic>Vectors. Intermediate hosts</topic><topic>yellowfever mosquito</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chauhan, Kamlesh R.</creatorcontrib><creatorcontrib>Klun, Jerome A.</creatorcontrib><creatorcontrib>Debboun, Mustapha</creatorcontrib><creatorcontrib>Kramer, Matthew</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of medical entomology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chauhan, Kamlesh R.</au><au>Klun, Jerome A.</au><au>Debboun, Mustapha</au><au>Kramer, Matthew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feeding Deterrent Effects of Catnip Oil Components Compared with Two Synthetic Amides Against Aedes aegypti</atitle><jtitle>Journal of medical entomology</jtitle><addtitle>J Med Entomol</addtitle><date>2005-07</date><risdate>2005</risdate><volume>42</volume><issue>4</issue><spage>643</spage><epage>646</epage><pages>643-646</pages><issn>0022-2585</issn><eissn>1938-2928</eissn><coden>JMENA6</coden><abstract>Recently, catnip, Nepeta cataria L. (Lamiaceae), essential oil has been formulated and marketed as an alternative repellent for protection against biting arthropods by several vendors. We isolated the major active components of catnip oil, E,Z- and Z,E-nepetalactone, and quantitatively measured their antibiting efficacy compared with the repellents N,N-diethyl-3-methylbenzamide (deet) and chiral (1S,2′S)-2-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS220) against the yellowfever mosquito, Aedes aegypti (L.), by using an in vitro assay and human volunteers at 24 nmol compound/cm2 (cloth or skin). Of all compounds tested in an in vitro assay, SS220 ranked as the most effective, whereas catnip oil and the nepetalactone compounds did not differ significantly from each other or from deet. However, in human volunteer bioassays, neither E,Z and Z,E-nepetalactone nor racemic nepetalactone deterred mosquito biting as effectively as SS220 or deet. All compounds differed significantly from the control. We conclude that catnip oil and nepetalactone isomers are significantly less effective than deet or SS220 in deterring the biting of Ae. aegypti.</abstract><cop>Lanham, MD</cop><pub>Entomological Society of America</pub><pmid>16119554</pmid><doi>10.1603/0022-2585%282005%29042%5B0643%3AFDEOCO%5D2.0.CO%3B2</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of medical entomology, 2005-07, Vol.42 (4), p.643-646 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; BioOne Complete |
| subjects | Aedes - physiology Aedes aegypti amides Animals antifeeding activity bioassays Biological and medical sciences biting rates Cyclohexenes Cyclopentanes - administration & dosage deet DEET - administration & dosage essential oils Fundamental and applied biological sciences. Psychology Humans Insect Bites and Stings - prevention & control insect repellents Insect Repellents - administration & dosage isomers lactones Medically important nuisances and vectors, pests of stored products and materials: population survey and control mosquito bites mosquito control Nepeta - chemistry Nepeta cataria nepetalactone Piperidines - administration & dosage Plant Oils - chemistry Pyrones - administration & dosage repellency repellents SS220 VECTOR CONTROL, PEST MANAGEMENT, RESISTANCE, REPELLENTS Vectors. Intermediate hosts yellowfever mosquito |
| title | Feeding Deterrent Effects of Catnip Oil Components Compared with Two Synthetic Amides Against Aedes aegypti |
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