Thyroid Hormones Affect Neurogenesis in the Dentate Gyrus of Adult Rat
Thyroid hormones play a crucial role in new neuron production and maturation during brain development. However, the knowledge about the involvement of these hormones on adult neurogenesis is still incomplete. Hippocampus is an anatomical region where neurogenesis occurs throughout adulthood and wher...
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| Veröffentlicht in: | Neuroendocrinology 2005-01, Vol.81 (4), p.244-253 |
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| creator | Ambrogini, Patrizia Cuppini, Riccardo Ferri, Paola Mancini, Cecilia Ciaroni, Sandra Voci, Adriana Gerdoni, Ezio Gallo, Gabriella |
| description | Thyroid hormones play a crucial role in new neuron production and maturation during brain development. However, the knowledge about the involvement of these hormones on adult neurogenesis is still incomplete. Hippocampus is an anatomical region where neurogenesis occurs throughout adulthood and where high levels of thyroid hormone receptors have been found. In this work the possible involvement of thyroid hormones in the regulation of adult neurogenesis in the granule cell layer of rat hippocampus dentate gyrus was investigated using an experimental model of adult-onset pharmacologically-induced hypothyroidism. Neurogenesis was assessed by means of the thymidine analogue 5-bromo-2′-deoxyuridine 24 h and 30 days after its last administration in order to study neural precursor proliferation and newborn cell survival, respectively. Mitotic activity of the neural precursors was not affected by thyroid hormone deficiency; on the contrary, newborn cell survival dramatically decreased under these conditions when compared with controls, leading to a lower number of immature neurons being added to the granule cell layer. Moreover, in conditions of hypothyroidism, new neurons exhibit a delay in neuronal differentiation showing a prolonged expression of the neuritogenesis-associated immature neuron marker TUC-4 and a very immature morphology. Finally, the total number and size of granule cells, and granule cell layer volume decreased in hypothyroid rats. These results suggest that thyroid hormones play a role in regulating new neuron production during adult life in dentate gyrus of rat hippocampus. |
| doi_str_mv | 10.1159/000087648 |
| format | Article |
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However, the knowledge about the involvement of these hormones on adult neurogenesis is still incomplete. Hippocampus is an anatomical region where neurogenesis occurs throughout adulthood and where high levels of thyroid hormone receptors have been found. In this work the possible involvement of thyroid hormones in the regulation of adult neurogenesis in the granule cell layer of rat hippocampus dentate gyrus was investigated using an experimental model of adult-onset pharmacologically-induced hypothyroidism. Neurogenesis was assessed by means of the thymidine analogue 5-bromo-2′-deoxyuridine 24 h and 30 days after its last administration in order to study neural precursor proliferation and newborn cell survival, respectively. Mitotic activity of the neural precursors was not affected by thyroid hormone deficiency; on the contrary, newborn cell survival dramatically decreased under these conditions when compared with controls, leading to a lower number of immature neurons being added to the granule cell layer. Moreover, in conditions of hypothyroidism, new neurons exhibit a delay in neuronal differentiation showing a prolonged expression of the neuritogenesis-associated immature neuron marker TUC-4 and a very immature morphology. Finally, the total number and size of granule cells, and granule cell layer volume decreased in hypothyroid rats. These results suggest that thyroid hormones play a role in regulating new neuron production during adult life in dentate gyrus of rat hippocampus.</description><identifier>ISSN: 0028-3835</identifier><identifier>EISSN: 1423-0194</identifier><identifier>DOI: 10.1159/000087648</identifier><identifier>PMID: 16113586</identifier><identifier>CODEN: NUNDAJ</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Animals ; Apoptosis ; Biological and medical sciences ; Cell Differentiation ; Cell Division ; Cell Survival ; Dentate Gyrus - cytology ; Fundamental and applied biological sciences. Psychology ; Hypothyroidism - blood ; Hypothyroidism - chemically induced ; In Situ Nick-End Labeling ; Nervous System - growth & development ; Neurons - cytology ; Original Paper ; Rats ; Rats, Sprague-Dawley ; Stem Cells - cytology ; Thyroid Hormones - physiology ; Thyroxine - blood ; Triiodothyronine - blood ; Vertebrates: endocrinology</subject><ispartof>Neuroendocrinology, 2005-01, Vol.81 (4), p.244-253</ispartof><rights>2005 S. Karger AG, Basel</rights><rights>2005 INIST-CNRS</rights><rights>Copyright 2005 S. Karger AG, Basel.</rights><rights>Copyright (c) 2005 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-afa555c654ab859335c6001c051d99b5810fdf086d89594d6c66c5e060b3a9713</citedby><cites>FETCH-LOGICAL-c457t-afa555c654ab859335c6001c051d99b5810fdf086d89594d6c66c5e060b3a9713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2430,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17112250$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16113586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ambrogini, Patrizia</creatorcontrib><creatorcontrib>Cuppini, Riccardo</creatorcontrib><creatorcontrib>Ferri, Paola</creatorcontrib><creatorcontrib>Mancini, Cecilia</creatorcontrib><creatorcontrib>Ciaroni, Sandra</creatorcontrib><creatorcontrib>Voci, Adriana</creatorcontrib><creatorcontrib>Gerdoni, Ezio</creatorcontrib><creatorcontrib>Gallo, Gabriella</creatorcontrib><title>Thyroid Hormones Affect Neurogenesis in the Dentate Gyrus of Adult Rat</title><title>Neuroendocrinology</title><addtitle>Neuroendocrinology</addtitle><description>Thyroid hormones play a crucial role in new neuron production and maturation during brain development. However, the knowledge about the involvement of these hormones on adult neurogenesis is still incomplete. Hippocampus is an anatomical region where neurogenesis occurs throughout adulthood and where high levels of thyroid hormone receptors have been found. In this work the possible involvement of thyroid hormones in the regulation of adult neurogenesis in the granule cell layer of rat hippocampus dentate gyrus was investigated using an experimental model of adult-onset pharmacologically-induced hypothyroidism. Neurogenesis was assessed by means of the thymidine analogue 5-bromo-2′-deoxyuridine 24 h and 30 days after its last administration in order to study neural precursor proliferation and newborn cell survival, respectively. Mitotic activity of the neural precursors was not affected by thyroid hormone deficiency; on the contrary, newborn cell survival dramatically decreased under these conditions when compared with controls, leading to a lower number of immature neurons being added to the granule cell layer. Moreover, in conditions of hypothyroidism, new neurons exhibit a delay in neuronal differentiation showing a prolonged expression of the neuritogenesis-associated immature neuron marker TUC-4 and a very immature morphology. Finally, the total number and size of granule cells, and granule cell layer volume decreased in hypothyroid rats. These results suggest that thyroid hormones play a role in regulating new neuron production during adult life in dentate gyrus of rat hippocampus.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation</subject><subject>Cell Division</subject><subject>Cell Survival</subject><subject>Dentate Gyrus - cytology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothyroidism - blood</subject><subject>Hypothyroidism - chemically induced</subject><subject>In Situ Nick-End Labeling</subject><subject>Nervous System - growth & development</subject><subject>Neurons - cytology</subject><subject>Original Paper</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stem Cells - cytology</subject><subject>Thyroid Hormones - physiology</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><subject>Vertebrates: endocrinology</subject><issn>0028-3835</issn><issn>1423-0194</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0M9LwzAUB_AgipvTg2dBgqDgoZofTZocx3SbMBRknkuWJltn18ykPey_N9Kxgbm88Pjw3uMLwDVGTxgz-YziExlPxQno45TQBGGZnoI-QkQkVFDWAxchrKMikpJz0MMcY8oE74PxfLXzrizg1PmNq02AQ2uNbuC7ab1bmtgpAyxr2KwMfDF1oxoDJzvfBugsHBZt1cBP1VyCM6uqYK72dQC-xq_z0TSZfUzeRsNZolOWNYmyijGmOUvVQjBJafwjhDViuJBywQRGtrBI8EJIJtOCa841M4ijBVUyw3QAHrq5W-9-WhOafFMGbapK1ca1ISeIEywzHuHdP7h2ra_jbTnJ0owIKbOIHjukvQvBG5tvfblRfpdjlP8lmx-SjfZ2P7BdbExxlPsoI7jfAxW0qqxXtS7D0WUYE8JQdDed-1Z-afwBdGt-AbRbhe0</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Ambrogini, Patrizia</creator><creator>Cuppini, Riccardo</creator><creator>Ferri, Paola</creator><creator>Mancini, Cecilia</creator><creator>Ciaroni, Sandra</creator><creator>Voci, Adriana</creator><creator>Gerdoni, Ezio</creator><creator>Gallo, Gabriella</creator><general>Karger</general><general>S. 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Psychology</topic><topic>Hypothyroidism - blood</topic><topic>Hypothyroidism - chemically induced</topic><topic>In Situ Nick-End Labeling</topic><topic>Nervous System - growth & development</topic><topic>Neurons - cytology</topic><topic>Original Paper</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Stem Cells - cytology</topic><topic>Thyroid Hormones - physiology</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ambrogini, Patrizia</creatorcontrib><creatorcontrib>Cuppini, Riccardo</creatorcontrib><creatorcontrib>Ferri, Paola</creatorcontrib><creatorcontrib>Mancini, Cecilia</creatorcontrib><creatorcontrib>Ciaroni, Sandra</creatorcontrib><creatorcontrib>Voci, Adriana</creatorcontrib><creatorcontrib>Gerdoni, Ezio</creatorcontrib><creatorcontrib>Gallo, Gabriella</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>Neuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ambrogini, Patrizia</au><au>Cuppini, Riccardo</au><au>Ferri, Paola</au><au>Mancini, Cecilia</au><au>Ciaroni, Sandra</au><au>Voci, Adriana</au><au>Gerdoni, Ezio</au><au>Gallo, Gabriella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid Hormones Affect Neurogenesis in the Dentate Gyrus of Adult Rat</atitle><jtitle>Neuroendocrinology</jtitle><addtitle>Neuroendocrinology</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>81</volume><issue>4</issue><spage>244</spage><epage>253</epage><pages>244-253</pages><issn>0028-3835</issn><eissn>1423-0194</eissn><coden>NUNDAJ</coden><abstract>Thyroid hormones play a crucial role in new neuron production and maturation during brain development. However, the knowledge about the involvement of these hormones on adult neurogenesis is still incomplete. Hippocampus is an anatomical region where neurogenesis occurs throughout adulthood and where high levels of thyroid hormone receptors have been found. In this work the possible involvement of thyroid hormones in the regulation of adult neurogenesis in the granule cell layer of rat hippocampus dentate gyrus was investigated using an experimental model of adult-onset pharmacologically-induced hypothyroidism. Neurogenesis was assessed by means of the thymidine analogue 5-bromo-2′-deoxyuridine 24 h and 30 days after its last administration in order to study neural precursor proliferation and newborn cell survival, respectively. Mitotic activity of the neural precursors was not affected by thyroid hormone deficiency; on the contrary, newborn cell survival dramatically decreased under these conditions when compared with controls, leading to a lower number of immature neurons being added to the granule cell layer. Moreover, in conditions of hypothyroidism, new neurons exhibit a delay in neuronal differentiation showing a prolonged expression of the neuritogenesis-associated immature neuron marker TUC-4 and a very immature morphology. Finally, the total number and size of granule cells, and granule cell layer volume decreased in hypothyroid rats. These results suggest that thyroid hormones play a role in regulating new neuron production during adult life in dentate gyrus of rat hippocampus.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>16113586</pmid><doi>10.1159/000087648</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Apoptosis Biological and medical sciences Cell Differentiation Cell Division Cell Survival Dentate Gyrus - cytology Fundamental and applied biological sciences. Psychology Hypothyroidism - blood Hypothyroidism - chemically induced In Situ Nick-End Labeling Nervous System - growth & development Neurons - cytology Original Paper Rats Rats, Sprague-Dawley Stem Cells - cytology Thyroid Hormones - physiology Thyroxine - blood Triiodothyronine - blood Vertebrates: endocrinology |
| title | Thyroid Hormones Affect Neurogenesis in the Dentate Gyrus of Adult Rat |
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