Psychiatric symptoms associated with ephedra use
The objective of this review is to describe psychiatric adverse events occurring after ingestion of dietary supplements containing herbal ephedra and to assess the possible relationship between supplement use and the events. The authors reviewed all adverse event reports related to dietary supplemen...
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Veröffentlicht in: | Expert opinion on drug safety 2005-09, Vol.4 (5), p.879-884 |
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description | The objective of this review is to describe psychiatric adverse events occurring after ingestion of dietary supplements containing herbal ephedra and to assess the possible relationship between supplement use and the events. The authors reviewed all adverse event reports related to dietary supplements containing herbal ephedra from US FDA MedWatch files as of 30 September, 2001. Psychosis, mania or severe agitation, severe depression, hallucinations, delusions, suicide attempts, paranoia and violent behaviour were classified as serious psychiatric events. Events were categorised based on the amount of information supporting a causal relationship. Out of almost 1800 total adverse events, 57 were classified as both psychiatric in nature and serious. Two-thirds of these psychiatric cases involved patients with pre-existing psychological/psychiatric conditions and/or use of other mood-altering medications or illicit substances. The majority of case reports were insufficiently documented to make an informed judgment about a relationship between the use of ephedra and the adverse event in question. The case reports evaluated do not prove a definitive causal link between ephedra and psychiatric complications. However, they do raise concern that such a relationship may exist. |
doi_str_mv | 10.1517/14740338.4.5.879 |
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The authors reviewed all adverse event reports related to dietary supplements containing herbal ephedra from US FDA MedWatch files as of 30 September, 2001. Psychosis, mania or severe agitation, severe depression, hallucinations, delusions, suicide attempts, paranoia and violent behaviour were classified as serious psychiatric events. Events were categorised based on the amount of information supporting a causal relationship. Out of almost 1800 total adverse events, 57 were classified as both psychiatric in nature and serious. Two-thirds of these psychiatric cases involved patients with pre-existing psychological/psychiatric conditions and/or use of other mood-altering medications or illicit substances. The majority of case reports were insufficiently documented to make an informed judgment about a relationship between the use of ephedra and the adverse event in question. The case reports evaluated do not prove a definitive causal link between ephedra and psychiatric complications. However, they do raise concern that such a relationship may exist.</description><identifier>ISSN: 1474-0338</identifier><identifier>EISSN: 1744-764X</identifier><identifier>DOI: 10.1517/14740338.4.5.879</identifier><identifier>PMID: 16111450</identifier><language>eng</language><publisher>England: Ashley Publications Ltd</publisher><subject>Adverse Drug Reaction Reporting Systems - statistics & numerical data ; adverse event ; Dietary Supplements - adverse effects ; ephedra ; Ephedra - chemistry ; Humans ; Mental Disorders - chemically induced ; Phytotherapy - adverse effects ; Plant Preparations - adverse effects ; Plant Preparations - therapeutic use ; psychosis ; Psychotic Disorders - etiology ; Risk Factors ; Substance-Related Disorders ; Suicide, Attempted</subject><ispartof>Expert opinion on drug safety, 2005-09, Vol.4 (5), p.879-884</ispartof><rights>Ashley Publications Ltd 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-8da85f853e86d941f038205d11936debba9b8a68738dc76d6d24dd3133784acb3</citedby><cites>FETCH-LOGICAL-c315t-8da85f853e86d941f038205d11936debba9b8a68738dc76d6d24dd3133784acb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1517/14740338.4.5.879$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1517/14740338.4.5.879$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16111450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maglione, Margaret</creatorcontrib><creatorcontrib>Miotto, Karen</creatorcontrib><creatorcontrib>Iguchi, Martin</creatorcontrib><creatorcontrib>Hilton, Lara</creatorcontrib><creatorcontrib>Shekelle, Paul</creatorcontrib><title>Psychiatric symptoms associated with ephedra use</title><title>Expert opinion on drug safety</title><addtitle>Expert Opin Drug Saf</addtitle><description>The objective of this review is to describe psychiatric adverse events occurring after ingestion of dietary supplements containing herbal ephedra and to assess the possible relationship between supplement use and the events. The authors reviewed all adverse event reports related to dietary supplements containing herbal ephedra from US FDA MedWatch files as of 30 September, 2001. Psychosis, mania or severe agitation, severe depression, hallucinations, delusions, suicide attempts, paranoia and violent behaviour were classified as serious psychiatric events. Events were categorised based on the amount of information supporting a causal relationship. Out of almost 1800 total adverse events, 57 were classified as both psychiatric in nature and serious. Two-thirds of these psychiatric cases involved patients with pre-existing psychological/psychiatric conditions and/or use of other mood-altering medications or illicit substances. The majority of case reports were insufficiently documented to make an informed judgment about a relationship between the use of ephedra and the adverse event in question. The case reports evaluated do not prove a definitive causal link between ephedra and psychiatric complications. However, they do raise concern that such a relationship may exist.</description><subject>Adverse Drug Reaction Reporting Systems - statistics & numerical data</subject><subject>adverse event</subject><subject>Dietary Supplements - adverse effects</subject><subject>ephedra</subject><subject>Ephedra - chemistry</subject><subject>Humans</subject><subject>Mental Disorders - chemically induced</subject><subject>Phytotherapy - adverse effects</subject><subject>Plant Preparations - adverse effects</subject><subject>Plant Preparations - therapeutic use</subject><subject>psychosis</subject><subject>Psychotic Disorders - etiology</subject><subject>Risk Factors</subject><subject>Substance-Related Disorders</subject><subject>Suicide, Attempted</subject><issn>1474-0338</issn><issn>1744-764X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRbK3ePUn-QOJO9zN6klI_oKAHBW_LZndDUpIm7KaU_Hu3tCIe9DTDvPO8zDsIXQPOgIG4BSooJkRmNGOZFPkJmoKgNBWcfp7GPsrpXp-gixDWGM85E-QcTYADAGV4ivBbGE1V68HXJglj2w9dGxIdQmfi0NlkVw9V4vrKWa-TbXCX6KzUTXBXxzpDH4_L98Vzunp9elk8rFJDgA2ptFqyUjLiJLc5hRITOcfMAuSEW1cUOi-k5lIQaY3glts5tZYAIUJSbQoyQ_jga3wXgnel6n3daj8qwGofXn2HV1QxFcNH5OaA9NuidfYHOKaNC_eHhXpTdr7Vu843Vg16bDpfer0xdVDkH_u7X3TldDNURnun1t3Wb-I3_r7tC6hoeoo</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Maglione, Margaret</creator><creator>Miotto, Karen</creator><creator>Iguchi, Martin</creator><creator>Hilton, Lara</creator><creator>Shekelle, Paul</creator><general>Ashley Publications Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20050901</creationdate><title>Psychiatric symptoms associated with ephedra use</title><author>Maglione, Margaret ; Miotto, Karen ; Iguchi, Martin ; Hilton, Lara ; Shekelle, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-8da85f853e86d941f038205d11936debba9b8a68738dc76d6d24dd3133784acb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adverse Drug Reaction Reporting Systems - statistics & numerical data</topic><topic>adverse event</topic><topic>Dietary Supplements - adverse effects</topic><topic>ephedra</topic><topic>Ephedra - chemistry</topic><topic>Humans</topic><topic>Mental Disorders - chemically induced</topic><topic>Phytotherapy - adverse effects</topic><topic>Plant Preparations - adverse effects</topic><topic>Plant Preparations - therapeutic use</topic><topic>psychosis</topic><topic>Psychotic Disorders - etiology</topic><topic>Risk Factors</topic><topic>Substance-Related Disorders</topic><topic>Suicide, Attempted</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maglione, Margaret</creatorcontrib><creatorcontrib>Miotto, Karen</creatorcontrib><creatorcontrib>Iguchi, Martin</creatorcontrib><creatorcontrib>Hilton, Lara</creatorcontrib><creatorcontrib>Shekelle, Paul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Expert opinion on drug safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maglione, Margaret</au><au>Miotto, Karen</au><au>Iguchi, Martin</au><au>Hilton, Lara</au><au>Shekelle, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychiatric symptoms associated with ephedra use</atitle><jtitle>Expert opinion on drug safety</jtitle><addtitle>Expert Opin Drug Saf</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>4</volume><issue>5</issue><spage>879</spage><epage>884</epage><pages>879-884</pages><issn>1474-0338</issn><eissn>1744-764X</eissn><abstract>The objective of this review is to describe psychiatric adverse events occurring after ingestion of dietary supplements containing herbal ephedra and to assess the possible relationship between supplement use and the events. The authors reviewed all adverse event reports related to dietary supplements containing herbal ephedra from US FDA MedWatch files as of 30 September, 2001. Psychosis, mania or severe agitation, severe depression, hallucinations, delusions, suicide attempts, paranoia and violent behaviour were classified as serious psychiatric events. Events were categorised based on the amount of information supporting a causal relationship. Out of almost 1800 total adverse events, 57 were classified as both psychiatric in nature and serious. Two-thirds of these psychiatric cases involved patients with pre-existing psychological/psychiatric conditions and/or use of other mood-altering medications or illicit substances. The majority of case reports were insufficiently documented to make an informed judgment about a relationship between the use of ephedra and the adverse event in question. The case reports evaluated do not prove a definitive causal link between ephedra and psychiatric complications. However, they do raise concern that such a relationship may exist.</abstract><cop>England</cop><pub>Ashley Publications Ltd</pub><pmid>16111450</pmid><doi>10.1517/14740338.4.5.879</doi><tpages>6</tpages></addata></record> |
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subjects | Adverse Drug Reaction Reporting Systems - statistics & numerical data adverse event Dietary Supplements - adverse effects ephedra Ephedra - chemistry Humans Mental Disorders - chemically induced Phytotherapy - adverse effects Plant Preparations - adverse effects Plant Preparations - therapeutic use psychosis Psychotic Disorders - etiology Risk Factors Substance-Related Disorders Suicide, Attempted |
title | Psychiatric symptoms associated with ephedra use |
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