A 6-month regimen for EPTB with intermittent treatment in the continuation phase: a study of 679 cases
BACKGROUND: No large studies have demonstrated the effectiveness of a 6-month regimen for all forms of extra-pulmonary tuberculosis (EPTB).METHODS: Retrospective, observational analysis to evaluate the effectiveness of a 6-month treatment regimen (2HRZE/4H3R3) for all patients diagnosed with EPTB in...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2005-08, Vol.9 (8), p.890-895 |
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| creator | CAMINERO, J. A FUENTES, Z. M MARTIN, T. Y ESPANA, M ISTURIZ, G. J MILLAN, E. Avila ALFONZO, E CASTILLO, O. Y CABRERA, P GUILARTE, A |
| description | BACKGROUND: No large studies have demonstrated the effectiveness of a 6-month regimen for all forms of extra-pulmonary tuberculosis (EPTB).METHODS: Retrospective, observational analysis to evaluate the effectiveness of a 6-month treatment regimen (2HRZE/4H3R3)
for all patients diagnosed with EPTB in Caracas, Venezuela, from 1 January 1998 to 31 December 2000, using direct observation.RESULTS: Of 679 patients enrolled, 101 (14.9%) had AIDS. In 83.2% the diagnosis was based on microbiological, histological or genetic amplification information.
Of 612 (90.1%) patients who took more than 90% of the doses, treatment had to be altered in six (1%) due to drug side effects. Of the remaining 606 patients who took more than 90% of the doses, 603 (99.5%) were cured and three failed. In the follow-up conducted 2 years after the end of treatment,
only 6 relapsed (1%). Cures without relapse were achieved in 24 cases of central nervous system involvement, 27 cases of osteoarticular involvement and in the 42 who had miliary and/or disseminated TB.CONCLUSION: A 6-month treatment regimen for all forms of EPTB, with treatment three times
a week during the continuation phase, was highly effective. |
| format | Article |
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for all patients diagnosed with EPTB in Caracas, Venezuela, from 1 January 1998 to 31 December 2000, using direct observation.RESULTS: Of 679 patients enrolled, 101 (14.9%) had AIDS. In 83.2% the diagnosis was based on microbiological, histological or genetic amplification information.
Of 612 (90.1%) patients who took more than 90% of the doses, treatment had to be altered in six (1%) due to drug side effects. Of the remaining 606 patients who took more than 90% of the doses, 603 (99.5%) were cured and three failed. In the follow-up conducted 2 years after the end of treatment,
only 6 relapsed (1%). Cures without relapse were achieved in 24 cases of central nervous system involvement, 27 cases of osteoarticular involvement and in the 42 who had miliary and/or disseminated TB.CONCLUSION: A 6-month treatment regimen for all forms of EPTB, with treatment three times
a week during the continuation phase, was highly effective.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>PMID: 16104636</identifier><language>eng</language><publisher>Paris, France: IUATLD</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antitubercular Agents - administration & dosage ; Antitubercular Agents - therapeutic use ; Bacterial diseases ; Bacterial diseases of the respiratory system ; Biological and medical sciences ; Directly Observed Therapy ; Drug Administration Schedule ; Drug Therapy, Combination ; Extra-Pulmonary Tuberculosis ; Female ; Human bacterial diseases ; Humans ; Infectious diseases ; Intermittent Treatment ; Male ; Medical sciences ; Middle Aged ; National Tuberculosis Programme ; Retrospective Studies ; Short-Course Treatment ; Treatment Outcome ; Tuberculosis - drug therapy ; Tuberculosis and atypical mycobacterial infections ; Venezuela</subject><ispartof>The international journal of tuberculosis and lung disease, 2005-08, Vol.9 (8), p.890-895</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16983727$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16104636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CAMINERO, J. A</creatorcontrib><creatorcontrib>FUENTES, Z. M</creatorcontrib><creatorcontrib>MARTIN, T. Y</creatorcontrib><creatorcontrib>ESPANA, M</creatorcontrib><creatorcontrib>ISTURIZ, G. J</creatorcontrib><creatorcontrib>MILLAN, E. Avila</creatorcontrib><creatorcontrib>ALFONZO, E</creatorcontrib><creatorcontrib>CASTILLO, O. Y</creatorcontrib><creatorcontrib>CABRERA, P</creatorcontrib><creatorcontrib>GUILARTE, A</creatorcontrib><title>A 6-month regimen for EPTB with intermittent treatment in the continuation phase: a study of 679 cases</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>BACKGROUND: No large studies have demonstrated the effectiveness of a 6-month regimen for all forms of extra-pulmonary tuberculosis (EPTB).METHODS: Retrospective, observational analysis to evaluate the effectiveness of a 6-month treatment regimen (2HRZE/4H3R3)
for all patients diagnosed with EPTB in Caracas, Venezuela, from 1 January 1998 to 31 December 2000, using direct observation.RESULTS: Of 679 patients enrolled, 101 (14.9%) had AIDS. In 83.2% the diagnosis was based on microbiological, histological or genetic amplification information.
Of 612 (90.1%) patients who took more than 90% of the doses, treatment had to be altered in six (1%) due to drug side effects. Of the remaining 606 patients who took more than 90% of the doses, 603 (99.5%) were cured and three failed. In the follow-up conducted 2 years after the end of treatment,
only 6 relapsed (1%). Cures without relapse were achieved in 24 cases of central nervous system involvement, 27 cases of osteoarticular involvement and in the 42 who had miliary and/or disseminated TB.CONCLUSION: A 6-month treatment regimen for all forms of EPTB, with treatment three times
a week during the continuation phase, was highly effective.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antitubercular Agents - administration & dosage</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the respiratory system</subject><subject>Biological and medical sciences</subject><subject>Directly Observed Therapy</subject><subject>Drug Administration Schedule</subject><subject>Drug Therapy, Combination</subject><subject>Extra-Pulmonary Tuberculosis</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Intermittent Treatment</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>National Tuberculosis Programme</subject><subject>Retrospective Studies</subject><subject>Short-Course Treatment</subject><subject>Treatment Outcome</subject><subject>Tuberculosis - drug therapy</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Venezuela</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLxDAUhYsovv-CZKO7Qh5tHu58Kwi60HW4k6YzGdp0TFJFf70pMwNuzCL3cPlyuDl3pzgkktSlUBTvZo2pKJkg6qA4inGJMSWEiP3igHCCK874YdFeIV72g08LFOzc9dajdgjo7vXtGn253HU-2dC7lKxPKAULqZ-U8ygtLDL5pfMjJDd4tFpAtJcIUExj842GFnGhkMnNeFLstdBFe7qpx8X7_d3bzWP5_PLwdHP1XDomWCqJwVxhUQFn2GApFJ5R3ADhkhhqbF1R1RJRCwADMyahruRMKcIryaqGK8uOi4u17yoMH6ONSfcuGtt14O0wRs1lJRUVNINnG3Cc9bbRq-B6CN96m0wGzjcARANdG8AbF_9wSjJBReZu15zz8xwM6OUwBp__qF2OpWu0W043xbjWeH3UVkgNIeVKpnle_7MxW6dpndM29afyMjtSgiWtNalzq7EtjF3SCYKe_-iYLX8B3z6cfg</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>CAMINERO, J. 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Y ; CABRERA, P ; GUILARTE, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i373t-1c069074a630c08790b20da1681c2ce5429f1757aacab38a548b99164834d69e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antitubercular Agents - administration & dosage</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the respiratory system</topic><topic>Biological and medical sciences</topic><topic>Directly Observed Therapy</topic><topic>Drug Administration Schedule</topic><topic>Drug Therapy, Combination</topic><topic>Extra-Pulmonary Tuberculosis</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Intermittent Treatment</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>National Tuberculosis Programme</topic><topic>Retrospective Studies</topic><topic>Short-Course Treatment</topic><topic>Treatment Outcome</topic><topic>Tuberculosis - drug therapy</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Venezuela</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CAMINERO, J. A</creatorcontrib><creatorcontrib>FUENTES, Z. M</creatorcontrib><creatorcontrib>MARTIN, T. Y</creatorcontrib><creatorcontrib>ESPANA, M</creatorcontrib><creatorcontrib>ISTURIZ, G. J</creatorcontrib><creatorcontrib>MILLAN, E. Avila</creatorcontrib><creatorcontrib>ALFONZO, E</creatorcontrib><creatorcontrib>CASTILLO, O. Y</creatorcontrib><creatorcontrib>CABRERA, P</creatorcontrib><creatorcontrib>GUILARTE, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CAMINERO, J. A</au><au>FUENTES, Z. M</au><au>MARTIN, T. Y</au><au>ESPANA, M</au><au>ISTURIZ, G. J</au><au>MILLAN, E. Avila</au><au>ALFONZO, E</au><au>CASTILLO, O. Y</au><au>CABRERA, P</au><au>GUILARTE, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A 6-month regimen for EPTB with intermittent treatment in the continuation phase: a study of 679 cases</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>9</volume><issue>8</issue><spage>890</spage><epage>895</epage><pages>890-895</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>BACKGROUND: No large studies have demonstrated the effectiveness of a 6-month regimen for all forms of extra-pulmonary tuberculosis (EPTB).METHODS: Retrospective, observational analysis to evaluate the effectiveness of a 6-month treatment regimen (2HRZE/4H3R3)
for all patients diagnosed with EPTB in Caracas, Venezuela, from 1 January 1998 to 31 December 2000, using direct observation.RESULTS: Of 679 patients enrolled, 101 (14.9%) had AIDS. In 83.2% the diagnosis was based on microbiological, histological or genetic amplification information.
Of 612 (90.1%) patients who took more than 90% of the doses, treatment had to be altered in six (1%) due to drug side effects. Of the remaining 606 patients who took more than 90% of the doses, 603 (99.5%) were cured and three failed. In the follow-up conducted 2 years after the end of treatment,
only 6 relapsed (1%). Cures without relapse were achieved in 24 cases of central nervous system involvement, 27 cases of osteoarticular involvement and in the 42 who had miliary and/or disseminated TB.CONCLUSION: A 6-month treatment regimen for all forms of EPTB, with treatment three times
a week during the continuation phase, was highly effective.</abstract><cop>Paris, France</cop><pub>IUATLD</pub><pmid>16104636</pmid><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antitubercular Agents - administration & dosage Antitubercular Agents - therapeutic use Bacterial diseases Bacterial diseases of the respiratory system Biological and medical sciences Directly Observed Therapy Drug Administration Schedule Drug Therapy, Combination Extra-Pulmonary Tuberculosis Female Human bacterial diseases Humans Infectious diseases Intermittent Treatment Male Medical sciences Middle Aged National Tuberculosis Programme Retrospective Studies Short-Course Treatment Treatment Outcome Tuberculosis - drug therapy Tuberculosis and atypical mycobacterial infections Venezuela |
| title | A 6-month regimen for EPTB with intermittent treatment in the continuation phase: a study of 679 cases |
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