GABA, progesterone and zona pellucida activation of PLA2 and regulation by MEK‐ERK1/2 during acrosomal exocytosis in guinea pig spermatozoa

We investigated whether GABA activates phospholipase A2 (PLA2) during acrosomal exocytosis, and if the MEK‐ERK1/2 pathway modulates PLA2 activation initiated by GABA, progesterone or zona pellucida (ZP). In guinea pig spermatozoa prelabelled with [14C]arachidonic acid or [14C]choline chloride, GABA...

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Veröffentlicht in:	FEBS letters 2005-08, Vol.579 (21), p.4692-4700
Hauptverfasser:	Chen, Wen-Ying, Ni, Ya, Pan, Yong-Miao, Shi, Qi-Xian, Yuan, Yu-Ying, Chen, Ai-Jun, Mao, Li-Zhen, Yu, Shu-Qing, Roldan, Eduardo R.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosome Reaction - physiology Animals Arachidonic Acid - chemistry Arachidonic Acid - metabolism aristolochic acid Aristolochic Acids - metabolism ATA DAG diacylglycerol Diglycerides - metabolism Enzyme Activation ERK Exocytosis Exocytosis - physiology extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Female GABA gamma-Aminobutyric Acid - metabolism Guinea Pigs LCa2+-MCM low-calcium minimal capacitation medium Male MAP kinase MAP kinase (ERK) kinase MAP Kinase Signaling System - physiology MEK mitogen-activated protein kinase Mitogen-Activated Protein Kinase Kinases - metabolism phosphatidylcholine phospholipase A2 Phospholipases A - antagonists & inhibitors Phospholipases A - metabolism Phospholipases A2 PKA PKC PLA2 Progesterone Progesterone - metabolism protein kinase A protein kinase C Protein Kinase C - metabolism Spermatozoa - chemistry Spermatozoa - metabolism zona pellucida Zona Pellucida - metabolism γ-aminobutyric acid
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