Epithelial Membrane Protein-1 Is a Biomarker of Gefitinib Resistance

We describe a molecular resistance biomarker to gefitinib, epithelial membrane protein-1 (EMP-1). Gefitinib is a small-molecule inhibitor that competes for the ATP-binding site on EGF receptor (EGFR) and has been approved for patients with advanced lung cancers. Treatment with gefitinib has resulted...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-08, Vol.102 (33), p.11858-11863
Hauptverfasser:	Jain, Anjali, Tindell, Charles A., Laux, Isett, Hunter, Jacob B., Curran, John, Galkin, Anna, Afar, Daniel E., Aronson, Nina, Shak, Steven, Natale, Ronald B., Agus, David B., Carson, Dennis A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Animals Biological markers Biological Sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Drug resistance Drug Resistance, Neoplasm Drug therapy Female Gefitinib Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects General practice Heterologous transplantation Humans Inhibitor drugs Lung cancer Lung neoplasms Male Messenger RNA Mice Models, Animal Molecular biology Mutation - genetics Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Prostatic Neoplasms - pathology Proteins Quinazolines - pharmacology Receptors Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Somatic mutation Tumors Xenograft Model Antitumor Assays
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