Acute Functional Enhancement of Circulatory Neutrophils After Intratracheal Instillation with Diesel Exhaust Particles in Rats

Abstract We have previously demonstrated that intratracheal instillation (IT) with diesel exhaust particles (DEP) exacerbates myocardial ischemia/reperfusion-induced arrhythmia in rats. Since activated neutrophils play a pivotal role in ischemia/reperfusion arrhythmia, in the present study we invest...

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Veröffentlicht in:	Inhalation toxicology 2005-11, Vol.17 (12), p.671-679
Hauptverfasser:	Yokota, Syunji, Seki, Takayuki, Furuya, Mami, Ohara, Naoki
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants - toxicity Animals Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Cell Count Chemokine CXCL1 Chemokine CXCL2 Chemokines, CXC - blood Chemokines, CXC - metabolism Intercellular Signaling Peptides and Proteins - blood Intercellular Signaling Peptides and Proteins - metabolism Intubation, Intratracheal Male Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Time Factors Tumor Necrosis Factor-alpha - metabolism Vehicle Emissions - toxicity
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