Improvement of Lyme Borreliosis Serodiagnosis by a Newly Developed Recombinant Immunoglobulin G (IgG) and IgM Line Immunoblot Assay and Addition of VlsE and DbpA Homologues

We developed and evaluated a recombinant Borrelia line immunoblot assay based on 18 homologues of seven different antigens, i.e., p100, p58, p41i, BmpA, VlsE, OspC, and DbpA. Each recombinant antigen can be detected separately and is distinct even from homologues with identical molecular weights. Th...

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Veröffentlicht in:	Journal of Clinical Microbiology 2005-08, Vol.43 (8), p.3602-3609
Hauptverfasser:	Goettner, Gereon, Schulte-Spechtel, Ulrike, Hillermann, Ruth, Liegl, Gabi, Wilske, Bettina, Fingerle, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - immunology Antibodies, Bacterial - blood Antigens, Bacterial - immunology Bacterial diseases Bacterial Outer Membrane Proteins - immunology Bacterial Proteins - immunology Bacteriology Biological and medical sciences Borrelia burgdorferi - immunology Borrelia infections Fundamental and applied biological sciences. Psychology Human bacterial diseases Humans Immunoblotting Immunoglobulin G - blood Immunoglobulin M - blood Infectious diseases Lipoproteins - immunology Lyme Disease - diagnosis Medical sciences Microbiology Recombinant Proteins - immunology Sensitivity and Specificity Serologic Tests - methods Tropical bacterial diseases
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