Warfarin-induced leukocytoclastic vasculitis
Skin reactions associated with oral coumarin-derived anticoagulants are an uncommon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 patients with late-onset LV probably due to warfarin. All 4 p...
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| Veröffentlicht in: | Cutis (New York, N.Y.) N.Y.), 2005-06, Vol.75 (6), p.329 |
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| container_title | Cutis (New York, N.Y.) |
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| creator | Yaghoubian, Bahareh Ngo, Binh Mak, May Ostrzega, Enrique Tesoro, Jane Mitani, Gladys H Moriguchi |
| description | Skin reactions associated with oral coumarin-derived anticoagulants are an uncommon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 patients with late-onset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed after receiving warfarin for several years. The results of skin lesion biopsies were available in 3 patients, confirming LV Cutaneous lesions resolved in all patients after warfarin was discontinued. In 2 of the 4 patients, rechallenge with warfarin led to recurrence of the lesions. LV may be a late-onset adverse reaction associated with warfarin therapy. |
| format | Article |
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Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 patients with late-onset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed after receiving warfarin for several years. The results of skin lesion biopsies were available in 3 patients, confirming LV Cutaneous lesions resolved in all patients after warfarin was discontinued. In 2 of the 4 patients, rechallenge with warfarin led to recurrence of the lesions. 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Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 patients with late-onset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed after receiving warfarin for several years. The results of skin lesion biopsies were available in 3 patients, confirming LV Cutaneous lesions resolved in all patients after warfarin was discontinued. In 2 of the 4 patients, rechallenge with warfarin led to recurrence of the lesions. LV may be a late-onset adverse reaction associated with warfarin therapy.</description><subject>Adult</subject><subject>Anticoagulants - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Vasculitis, Leukocytoclastic, Cutaneous - chemically induced</subject><subject>Warfarin - adverse effects</subject><issn>0011-4162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1jsuKAjEQAHNwUVf9BfEDDHSSMZk-irgPEPYi7FEy6TRERx0mM4J_v8LqqahLUQMxBlBKFsrqkXjP-fhQ1M4NxUhZKFzp1Fgsf33Lvk0XmS7Uh0iLOvana7h311D73KWwuPkc-jp1KU_FG_s6x9mTE7H_2O43X3L38_m9We9kowE7qTDSClwJFtmSrjRbjeDZVMqAQQ7ReMWmZChIP0aIIFKJFDVyhWAmYv6fbfrqHOnQtOns2_vhdW3-AIlhPWc</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Yaghoubian, Bahareh</creator><creator>Ngo, Binh</creator><creator>Mak, May</creator><creator>Ostrzega, Enrique</creator><creator>Tesoro, Jane</creator><creator>Mitani, Gladys H Moriguchi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200506</creationdate><title>Warfarin-induced leukocytoclastic vasculitis</title><author>Yaghoubian, Bahareh ; Ngo, Binh ; Mak, May ; Ostrzega, Enrique ; Tesoro, Jane ; Mitani, Gladys H Moriguchi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-19ed5078069f6d2b2f6290af3b13039fce3a1f38f04d2047dd0ed89de29fb903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Anticoagulants - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Vasculitis, Leukocytoclastic, Cutaneous - chemically induced</topic><topic>Warfarin - adverse effects</topic><toplevel>online_resources</toplevel><creatorcontrib>Yaghoubian, Bahareh</creatorcontrib><creatorcontrib>Ngo, Binh</creatorcontrib><creatorcontrib>Mak, May</creatorcontrib><creatorcontrib>Ostrzega, Enrique</creatorcontrib><creatorcontrib>Tesoro, Jane</creatorcontrib><creatorcontrib>Mitani, Gladys H Moriguchi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cutis (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yaghoubian, Bahareh</au><au>Ngo, Binh</au><au>Mak, May</au><au>Ostrzega, Enrique</au><au>Tesoro, Jane</au><au>Mitani, Gladys H Moriguchi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Warfarin-induced leukocytoclastic vasculitis</atitle><jtitle>Cutis (New York, N.Y.)</jtitle><addtitle>Cutis</addtitle><date>2005-06</date><risdate>2005</risdate><volume>75</volume><issue>6</issue><spage>329</spage><pages>329-</pages><issn>0011-4162</issn><abstract>Skin reactions associated with oral coumarin-derived anticoagulants are an uncommon occurrence. Leukocytoclastic vasculitis (LV) is primarily a cutaneous small vessel vasculitis, though systemic involvement may be encountered. We report 4 patients with late-onset LV probably due to warfarin. All 4 patients presented with skin eruptions that developed after receiving warfarin for several years. The results of skin lesion biopsies were available in 3 patients, confirming LV Cutaneous lesions resolved in all patients after warfarin was discontinued. In 2 of the 4 patients, rechallenge with warfarin led to recurrence of the lesions. LV may be a late-onset adverse reaction associated with warfarin therapy.</abstract><cop>United States</cop><pmid>16047871</pmid></addata></record> |
| fulltext | fulltext |
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| ispartof | Cutis (New York, N.Y.), 2005-06, Vol.75 (6), p.329 |
| issn | 0011-4162 |
| language | eng |
| recordid | cdi_pubmed_primary_16047871 |
| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Adult Anticoagulants - adverse effects Female Humans Male Middle Aged Vasculitis, Leukocytoclastic, Cutaneous - chemically induced Warfarin - adverse effects |
| title | Warfarin-induced leukocytoclastic vasculitis |
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