The Solution Structure of the Josephin Domain of Ataxin-3: Structural Determinants for Molecular Recognition

The Josephin domain plays an important role in the cellular functions of ataxin-3, the protein responsible for the neurodegenerative Machado-Joseph disease. We have determined the solution structure of Josephin and shown that it belongs to the family of papain-like cysteine proteases, sharing the hi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-07, Vol.102 (30), p.10493-10498
Hauptverfasser:	Nicastro, Giuseppe, Menon, Rajesh P., Masino, Laura, Knowles, Philip P., McDonald, Neil Q., Pastore, Annalisa, Hendrickson, Wayne A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Ataxin-3 Biological Sciences Cellular biology Chemical equilibrium Coordinate systems Dipeptides Disease models DNA Repair Enzymes DNA-Binding Proteins Enzymes Escherichia coli Histones Leucine - analogs & derivatives Machado Joseph disease Machado-Joseph Disease - enzymology Models, Molecular Molecular structure Nerve Tissue Proteins - chemistry Nitrogen Isotopes Nuclear Magnetic Resonance, Biomolecular Nuclear Proteins Protease inhibitors Protein Structure, Tertiary Proteins Repressor Proteins Solutions Substrate Specificity
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