Gating of Proton and Water Transfer in the Respiratory Enzyme Cytochrome c Oxidase

The membrane-bound enzyme cytochrome c oxidase is responsible for cell respiration in aerobic organisms and conserves free energy from O2reduction into an electrochemical proton gradient by coupling the redox reaction to proton-pumping across the membrane. O2reduction produces water at the bimetalli...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-07, Vol.102 (30), p.10478-10481
Hauptverfasser:	Wikström, Mårten, Ribacka, Camilla, Molin, Mika, Laakkonen, Liisa, Verkhovsky, Michael, Puustinen, Anne, Gray, Harry B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - metabolism Atoms Biological Sciences Biological Transport - physiology Cattle Computer Simulation Cytochromes Electron Transport Complex IV - chemistry Electron Transport Complex IV - genetics Enzymes Heme - analogs & derivatives Heme - metabolism Ion Channel Gating - genetics Ion Channel Gating - physiology Ions Molecules Mutagenesis, Site-Directed Oxidases Paracoccus denitrificans Propionates Propionates - metabolism Proton Pumps - physiology Protons Respiratory system Ungulates Water Water - chemistry Water - physiology Water conservation
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