Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography

AMPA receptor potentiating drugs (e.g. ampakines) enhance glutamatergic neurotransmission, and may have potential therapeutic consequences in CNS disorders. The neuroanatomical basis of action for these compounds is at present unclear. This study aimed to identify the effects of two novel ampakines,...

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Veröffentlicht in:	Neuropharmacology 2005-08, Vol.49 (2), p.254-264
Hauptverfasser:	Jordan, Graeme R., McCulloch, James, Shahid, Mohammed, Hill, David R., Henry, Brian, Horsburgh, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	14C-autoradiography alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - agonists AMPA Ampakine Animals Autoradiography - methods Brain - drug effects Brain Chemistry - drug effects Carbon Radioisotopes - metabolism Cerebrovascular Circulation - drug effects Deoxyglucose - metabolism Dose-Response Relationship, Drug Drug Interactions Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Glucose - metabolism Male Mice Mice, Inbred C57BL Org 24448 Org 26576 Potentiator Quinoxalines - pharmacology
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