Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit

GABAergic synaptic transmission plays an important role in the patterning of epileptiform activity. We have previously shown that global loss of GABA(B) receptor function due to transgenic deletion of the GABA(B1) receptor subunit exacerbates epileptiform activity induced by pharmacological manipula...

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Veröffentlicht in:	Epilepsy research 2005-06, Vol.65 (1-2), p.41
Hauptverfasser:	Thuault, Sébastien J, Brown, Jon T, Calver, Andrew R, Collingridge, Graham L, Randall, Andrew, Davies, Ceri H
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - pharmacology Animals Bicuculline - pharmacology Drug Interactions Electric Stimulation - methods Embryo, Mammalian Epilepsy - genetics Epilepsy - metabolism Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology GABA Antagonists - pharmacology Gene Deletion Hippocampus - metabolism In Vitro Techniques Magnesium - metabolism Membrane Potentials - drug effects Membrane Potentials - physiology Mice Mice, Knockout Phosphinic Acids - pharmacology Potassium Channel Blockers - pharmacology Propanolamines - pharmacology Pyramidal Cells Quinolinium Compounds - pharmacology Receptors, GABA-B - chemistry Receptors, GABA-B - deficiency Receptors, GABA-B - metabolism Time Factors Valine - analogs & derivatives Valine - pharmacology
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