Dosimetric Evaluation of Immunoscintigraphy Using Indium-111-Labeled Monoclonal Antibody Fragments in Patients with Ovarian Cancer
This study reports the biodistribution and dosimetry for a monoclonal antibody against ovarian carcinoma. Eight patients received 140 MBq 111In-OV-TL 3 F(ab')2; thereafter gamma camera imaging was performed daily up to 96 hr. By using the conjugated view counting method, activity in the organs...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1992-06, Vol.33 (6), p.1113 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Buijs, Wilhelmina C.A.M Massuger, Leon F.A.G Claessens, Roland A.M.J Kenemans, Peter Corstens, Frans H. M |
| description | This study reports the biodistribution and dosimetry for a monoclonal antibody against ovarian carcinoma. Eight patients received 140 MBq 111In-OV-TL 3 F(ab')2; thereafter gamma camera imaging was performed daily up to 96 hr. By using the conjugated view counting method, activity in the organs was quantitated by phantom calibration and by whole-body measurements using a whole-body counter with the conjugated view counting method. Red bone marrow uptake was derived from regions of interest over the lumbar vertebrae and iliac crest. In both methods, organ uptake varied only slightly with time, having a mean value of approximately 18%, 4%, 6% and 17% of the injected dose in the liver, spleen, kidneys and red bone marrow, respectively. The mean radiation dose to these organs was 0.9, 1.5, 1.2 and 0.5 mGy/MBq. The effective dose equivalent was 0.4 mSv/MBq. In this study, two different methods of uptake calculations, result in similar values of organ uptake. |
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The effective dose equivalent was 0.4 mSv/MBq. 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M</creatorcontrib><title>Dosimetric Evaluation of Immunoscintigraphy Using Indium-111-Labeled Monoclonal Antibody Fragments in Patients with Ovarian Cancer</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>This study reports the biodistribution and dosimetry for a monoclonal antibody against ovarian carcinoma. Eight patients received 140 MBq 111In-OV-TL 3 F(ab')2; thereafter gamma camera imaging was performed daily up to 96 hr. By using the conjugated view counting method, activity in the organs was quantitated by phantom calibration and by whole-body measurements using a whole-body counter with the conjugated view counting method. Red bone marrow uptake was derived from regions of interest over the lumbar vertebrae and iliac crest. In both methods, organ uptake varied only slightly with time, having a mean value of approximately 18%, 4%, 6% and 17% of the injected dose in the liver, spleen, kidneys and red bone marrow, respectively. The mean radiation dose to these organs was 0.9, 1.5, 1.2 and 0.5 mGy/MBq. The effective dose equivalent was 0.4 mSv/MBq. In this study, two different methods of uptake calculations, result in similar values of organ uptake.</description><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Indium Radioisotopes - pharmacokinetics</subject><subject>Middle Aged</subject><subject>Ovarian Neoplasms - diagnostic imaging</subject><subject>Radiation Dosage</subject><subject>Radioimmunodetection</subject><subject>Tissue Distribution</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkE9rwjAAxcPYcM7tIwxy2ymQNM0fj-J0Cg53mOeSJrGNNImkreJ1n3zd9PQevB8P3rsDY8IoQ4xzcQ_GmHCCGMPsETy17QFjzKWUIzAibCpExsbg5z22ztsuOQ0XJ9X0qnMxwLiHa-_7EFvtQueqpI71Be5aFyq4Dsb1HhFC0EaVtrEGfsYQdRODauBswMtoLnCZVOVt6FroAvwaav_92XU13J5UcirAuQrapmfwsFdNa19uOgG75eJ7vkKb7cd6PtugOqOyQ4TnmchUZgQtZc6tKKcaZ0JoIzMmjcyZtLmUe6UNJowLzinO8ykTuJQl15JOwOu199iX3primJxX6VLcvhjyt2teu6o-u2SL0OvGqvQHH4KntODFsJrSX1WyamI</recordid><startdate>19920601</startdate><enddate>19920601</enddate><creator>Buijs, Wilhelmina C.A.M</creator><creator>Massuger, Leon F.A.G</creator><creator>Claessens, Roland A.M.J</creator><creator>Kenemans, Peter</creator><creator>Corstens, Frans H. 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Red bone marrow uptake was derived from regions of interest over the lumbar vertebrae and iliac crest. In both methods, organ uptake varied only slightly with time, having a mean value of approximately 18%, 4%, 6% and 17% of the injected dose in the liver, spleen, kidneys and red bone marrow, respectively. The mean radiation dose to these organs was 0.9, 1.5, 1.2 and 0.5 mGy/MBq. The effective dose equivalent was 0.4 mSv/MBq. In this study, two different methods of uptake calculations, result in similar values of organ uptake.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>1597725</pmid></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 1992-06, Vol.33 (6), p.1113 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Female Humans Indium Radioisotopes - pharmacokinetics Middle Aged Ovarian Neoplasms - diagnostic imaging Radiation Dosage Radioimmunodetection Tissue Distribution |
| title | Dosimetric Evaluation of Immunoscintigraphy Using Indium-111-Labeled Monoclonal Antibody Fragments in Patients with Ovarian Cancer |
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