Treatment of experimental septic shock with microencapsulated antisense oligomers to NF-kappaB

NF-kappaB is an ideal target for inhibition of proinflammatory cytokines. The purpose of this study was to determine if microencapsulated antisense oligomer to NF-kappaB can inhibit proinflammatory cytokine release in response to Escherichia coli endotoxin and bacteria. Microencapsulation takes adva...

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Veröffentlicht in:	Journal of interferon & cytokine research 2005-06, Vol.25 (6), p.311
Hauptverfasser:	D'Souza, Martin J, Jin, Zhaowei, Oettinger, Carl W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Capsules Cells, Cultured Cytokines - blood Endotoxins - toxicity NF-kappa B - genetics Oligodeoxyribonucleotides, Antisense - administration & dosage Oligodeoxyribonucleotides, Antisense - genetics Peritonitis - blood Peritonitis - chemically induced Peritonitis - drug therapy Rats Rats, Inbred F344 Shock, Septic - blood Shock, Septic - chemically induced Shock, Septic - drug therapy
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