The protein stannin binds 14-3-3zeta and modulates mitogen-activated protein kinase signaling

The molecular mechanisms underlying the selective toxicity of trimethyltin (TMT) remain unclear. Stannin (Snn), a protein preferentially expressed in TMT-sensitive cells, provides a direct link to the molecular basis for TMT toxicity. Recent evidence demonstrated that Snn peptides bind and de-alkyla...

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Veröffentlicht in:	Brain research. Molecular brain research. 2005-08, Vol.138 (2), p.256
Hauptverfasser:	Davidson, Collin E, Reese, Brian E, Billingsley, Melvin L, Yun, Jong K
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - metabolism Amino Acid Motifs - physiology Amino Acid Sequence - drug effects Amino Acid Sequence - physiology Animals Binding Sites - physiology Brain - drug effects Brain - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism MAP Kinase Signaling System - physiology Neurons - drug effects Neurons - metabolism Neuropeptides - chemistry Neuropeptides - metabolism Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - physiopathology Neurotoxins - toxicity p38 Mitogen-Activated Protein Kinases - metabolism PC12 Cells Protein Binding - physiology Rats Trimethyltin Compounds - toxicity
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