Contribution of the Mycobacterium tuberculosis MmpL Protein Family to Virulence and Drug Resistance

The genome sequence of Mycobacterium tuberculosis revealed the presence of 12 membrane proteins proposed to have a function in the transport of lipids. Insertional inactivation of 11 of these has revealed that only 1 (MmpL3) is apparently essential for viability. Five of these proteins are conserved...

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Veröffentlicht in:	Infection and Immunity 2005-06, Vol.73 (6), p.3492-3501
Hauptverfasser:	Domenech, Pilar, Reed, Michael B, Barry, Clifton E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Animals Bacterial Proteins - physiology Biological and medical sciences Drug Resistance, Bacterial Fundamental and applied biological sciences. Psychology Membrane Proteins - physiology Mice Mice, Inbred C57BL Mice, Inbred DBA Microbiology Molecular Pathogenesis Mycobacterium leprae Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - pathogenicity Virulence
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