Search of amantadine-resistance in influenza A strains isolated in Santiago, Chile, 2001-2002

Amantadine has been used for prevention and treatment of influenza A infection. It blocks the proton through the M2 ion channel. Drug-resistant viruses appear quickly when this therapy is used. Single amino acids changes in the H2 protein can confer resistance, being the most frequent one in positio...

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Veröffentlicht in:	Revista chilena de infectología 2005-06, Vol.22 (2), p.141
Hauptverfasser:	Fehlmann, Elisa, Le Corre, Nicole, Abarca, Katia, Godoy, Paula, Montecinos, Luisa, Veloz, Ana, Ferrés, Marcela
Format:	Artikel
Sprache:	spa
Schlagworte:	Adolescent Adult Aged Amantadine - pharmacology Animals Antiviral Agents - pharmacology Cell Line Child Child, Preschool Chile Dogs Drug Resistance, Viral - genetics Female Humans Infant Influenza A virus - drug effects Influenza A virus - genetics Male Middle Aged Mutation Polymerase Chain Reaction Polymorphism, Restriction Fragment Length RNA, Viral - genetics RNA, Viral - isolation & purification Viral Matrix Proteins - genetics
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