Observing the 1H NMR signal of the myoglobin Val-E11 in myocardium: an index of cellular oxygenation

The 1H NMR signal from oxymyoglobin, a low-concentration diamagnetic protein, is visible in myocardial tissue. The methyl group of the Val-E11 resonates in a clear spectral region at -2.76 ppm and responds to dynamic changes in cellular oxygenation. With CO, the signal shifts to -2.4 ppm. The Val-E1...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-05, Vol.89 (10), p.4731-4733
Hauptverfasser:	KREUTZER, U, WANG, D. S, JUE, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Hemoproteins Hydrogen Magnetic Resonance Spectroscopy - methods Male Metalloproteins Myocardium - metabolism Myoglobin - metabolism Oxygen Consumption Phosphocreatine - metabolism Proteins Rats Rats, Inbred Strains Valine
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