Colonic Rupture in a Patient on Combination Chemotherapy for Metastasized Carcinoma of the Esophagogastric Junction. Case Report and Review of the Literature
Background: Cecal perforation due to neutropenic colitis is a known and described side effect of many chemother-apy regimens. We present a case of a patient with gastric adenocarcinoma who developed spontaneous cecal per-foration during chemotherapy without the classic pattern of typhlitis. Case Rep...
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| Veröffentlicht in: | Oncology research and treatment 2005-04, Vol.28 (4), p.204-206 |
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| container_title | Oncology research and treatment |
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| creator | Colucci, Gianluca Thaler, Walter Dejaco, Hans Marsoner, Hansjörg Grones, Alexia |
| description | Background: Cecal perforation due to neutropenic colitis
is a known and described side effect of many chemother-apy
regimens. We present a case of a patient with gastric
adenocarcinoma who developed spontaneous cecal per-foration
during chemotherapy without the classic pattern
of typhlitis. Case Report: A 58-year-old woman was on
chemotherapy for an adenocarcinoma of the gastric
junction, when she developed a cecal perforation. There
was neither evidence for leucopenia nor for typhlitis. La-parotomy
was performed and cecostomy was estab-lished
using the perforated bowel. Postoperative course
was uneventful. The patient died from tumor progres-sion
8 months after the diagnosis was made. Conclusion:
There is no evidence for a connection between this event
and chemotherapy treatment but neither can it be ex-cluded.
Even if unusual, colon toxicity could be a poten-tial
life-threatening complication associated with more
drugs than usually thought. |
| doi_str_mv | 10.1159/000084143 |
| format | Article |
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is a known and described side effect of many chemother-apy
regimens. We present a case of a patient with gastric
adenocarcinoma who developed spontaneous cecal per-foration
during chemotherapy without the classic pattern
of typhlitis. Case Report: A 58-year-old woman was on
chemotherapy for an adenocarcinoma of the gastric
junction, when she developed a cecal perforation. There
was neither evidence for leucopenia nor for typhlitis. La-parotomy
was performed and cecostomy was estab-lished
using the perforated bowel. Postoperative course
was uneventful. The patient died from tumor progres-sion
8 months after the diagnosis was made. Conclusion:
There is no evidence for a connection between this event
and chemotherapy treatment but neither can it be ex-cluded.
Even if unusual, colon toxicity could be a poten-tial
life-threatening complication associated with more
drugs than usually thought.</description><identifier>ISSN: 2296-5270</identifier><identifier>ISSN: 0378-584X</identifier><identifier>EISSN: 2296-5262</identifier><identifier>DOI: 10.1159/000084143</identifier><identifier>PMID: 15840969</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Adenocarcinoma - drug therapy ; Adenocarcinoma - secondary ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Case Report · Kasuistik ; Cecal Diseases - chemically induced ; Cisplatin - administration & dosage ; Cisplatin - adverse effects ; Colonic Diseases - chemically induced ; Esophagogastric Junction - pathology ; Female ; Fluorouracil - administration & dosage ; Fluorouracil - adverse effects ; Humans ; Intestinal Perforation - chemically induced ; Middle Aged ; Rupture - chemically induced ; Stomach Neoplasms - drug therapy ; Taxoids - administration & dosage ; Taxoids - adverse effects ; Treatment Outcome</subject><ispartof>Oncology research and treatment, 2005-04, Vol.28 (4), p.204-206</ispartof><rights>2005 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-a3a76df4085e597d732710258b041ab2770b1e4391e0da43e89b7cd00c6d4e933</citedby><cites>FETCH-LOGICAL-c396t-a3a76df4085e597d732710258b041ab2770b1e4391e0da43e89b7cd00c6d4e933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15840969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colucci, Gianluca</creatorcontrib><creatorcontrib>Thaler, Walter</creatorcontrib><creatorcontrib>Dejaco, Hans</creatorcontrib><creatorcontrib>Marsoner, Hansjörg</creatorcontrib><creatorcontrib>Grones, Alexia</creatorcontrib><title>Colonic Rupture in a Patient on Combination Chemotherapy for Metastasized Carcinoma of the Esophagogastric Junction. Case Report and Review of the Literature</title><title>Oncology research and treatment</title><addtitle>Oncol Res Treat</addtitle><description>Background: Cecal perforation due to neutropenic colitis
is a known and described side effect of many chemother-apy
regimens. We present a case of a patient with gastric
adenocarcinoma who developed spontaneous cecal per-foration
during chemotherapy without the classic pattern
of typhlitis. Case Report: A 58-year-old woman was on
chemotherapy for an adenocarcinoma of the gastric
junction, when she developed a cecal perforation. There
was neither evidence for leucopenia nor for typhlitis. La-parotomy
was performed and cecostomy was estab-lished
using the perforated bowel. Postoperative course
was uneventful. The patient died from tumor progres-sion
8 months after the diagnosis was made. Conclusion:
There is no evidence for a connection between this event
and chemotherapy treatment but neither can it be ex-cluded.
Even if unusual, colon toxicity could be a poten-tial
life-threatening complication associated with more
drugs than usually thought.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Adenocarcinoma - secondary</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Case Report · Kasuistik</subject><subject>Cecal Diseases - chemically induced</subject><subject>Cisplatin - administration & dosage</subject><subject>Cisplatin - adverse effects</subject><subject>Colonic Diseases - chemically induced</subject><subject>Esophagogastric Junction - pathology</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Fluorouracil - adverse effects</subject><subject>Humans</subject><subject>Intestinal Perforation - chemically induced</subject><subject>Middle Aged</subject><subject>Rupture - chemically induced</subject><subject>Stomach Neoplasms - drug therapy</subject><subject>Taxoids - administration & dosage</subject><subject>Taxoids - adverse effects</subject><subject>Treatment Outcome</subject><issn>2296-5270</issn><issn>0378-584X</issn><issn>2296-5262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1LwzAYB_AgihtzB8-CBG8eOpO-pTlKma_TydBzSZunW3RtStoq87v4XU3tnBdDIP_AL88THoSOKZlQGvALYlfkU9_bQ0PX5aETuKG7v8uMDNC4rl-tom4QRIwfogENIp_wkA_RV6zXulQZXrRV0xrAqsQCP4lGQdlgXeJYF6kq7b3LKyh0swIjqg3OtcEP0IjabvUJEsfCZKrUhcA6x1bhaa2rlVjqpTXGtrhry6yrM7G0BryASpsGi1La-K7g4_fdTDW2RfebI3SQi3UN4-05Qi9X0-f4xpnNr2_jy5mTeTxsHOEJFsrcJ1EAAWeSeS6jxA2ilPhUpC5jJKXge5wCkcL3IOIpyyQhWSh94J43Qud93czoujaQJ5VRhTCbhJKkm3Kym7K1p72t2rQA-Se3M7XgrAdvwizB7MD88f6nQlLJ3KKTf1Hf4xsMIo2K</recordid><startdate>200504</startdate><enddate>200504</enddate><creator>Colucci, Gianluca</creator><creator>Thaler, Walter</creator><creator>Dejaco, Hans</creator><creator>Marsoner, Hansjörg</creator><creator>Grones, Alexia</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200504</creationdate><title>Colonic Rupture in a Patient on Combination Chemotherapy for Metastasized Carcinoma of the Esophagogastric Junction. Case Report and Review of the Literature</title><author>Colucci, Gianluca ; Thaler, Walter ; Dejaco, Hans ; Marsoner, Hansjörg ; Grones, Alexia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-a3a76df4085e597d732710258b041ab2770b1e4391e0da43e89b7cd00c6d4e933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adenocarcinoma - drug therapy</topic><topic>Adenocarcinoma - secondary</topic><topic>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Case Report · Kasuistik</topic><topic>Cecal Diseases - chemically induced</topic><topic>Cisplatin - administration & dosage</topic><topic>Cisplatin - adverse effects</topic><topic>Colonic Diseases - chemically induced</topic><topic>Esophagogastric Junction - pathology</topic><topic>Female</topic><topic>Fluorouracil - administration & dosage</topic><topic>Fluorouracil - adverse effects</topic><topic>Humans</topic><topic>Intestinal Perforation - chemically induced</topic><topic>Middle Aged</topic><topic>Rupture - chemically induced</topic><topic>Stomach Neoplasms - drug therapy</topic><topic>Taxoids - administration & dosage</topic><topic>Taxoids - adverse effects</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colucci, Gianluca</creatorcontrib><creatorcontrib>Thaler, Walter</creatorcontrib><creatorcontrib>Dejaco, Hans</creatorcontrib><creatorcontrib>Marsoner, Hansjörg</creatorcontrib><creatorcontrib>Grones, Alexia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Oncology research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colucci, Gianluca</au><au>Thaler, Walter</au><au>Dejaco, Hans</au><au>Marsoner, Hansjörg</au><au>Grones, Alexia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colonic Rupture in a Patient on Combination Chemotherapy for Metastasized Carcinoma of the Esophagogastric Junction. Case Report and Review of the Literature</atitle><jtitle>Oncology research and treatment</jtitle><addtitle>Oncol Res Treat</addtitle><date>2005-04</date><risdate>2005</risdate><volume>28</volume><issue>4</issue><spage>204</spage><epage>206</epage><pages>204-206</pages><issn>2296-5270</issn><issn>0378-584X</issn><eissn>2296-5262</eissn><abstract>Background: Cecal perforation due to neutropenic colitis
is a known and described side effect of many chemother-apy
regimens. We present a case of a patient with gastric
adenocarcinoma who developed spontaneous cecal per-foration
during chemotherapy without the classic pattern
of typhlitis. Case Report: A 58-year-old woman was on
chemotherapy for an adenocarcinoma of the gastric
junction, when she developed a cecal perforation. There
was neither evidence for leucopenia nor for typhlitis. La-parotomy
was performed and cecostomy was estab-lished
using the perforated bowel. Postoperative course
was uneventful. The patient died from tumor progres-sion
8 months after the diagnosis was made. Conclusion:
There is no evidence for a connection between this event
and chemotherapy treatment but neither can it be ex-cluded.
Even if unusual, colon toxicity could be a poten-tial
life-threatening complication associated with more
drugs than usually thought.</abstract><cop>Basel, Switzerland</cop><pmid>15840969</pmid><doi>10.1159/000084143</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2296-5270 |
| ispartof | Oncology research and treatment, 2005-04, Vol.28 (4), p.204-206 |
| issn | 2296-5270 0378-584X 2296-5262 |
| language | eng |
| recordid | cdi_pubmed_primary_15840969 |
| source | Karger Journals; MEDLINE |
| subjects | Adenocarcinoma - drug therapy Adenocarcinoma - secondary Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Case Report · Kasuistik Cecal Diseases - chemically induced Cisplatin - administration & dosage Cisplatin - adverse effects Colonic Diseases - chemically induced Esophagogastric Junction - pathology Female Fluorouracil - administration & dosage Fluorouracil - adverse effects Humans Intestinal Perforation - chemically induced Middle Aged Rupture - chemically induced Stomach Neoplasms - drug therapy Taxoids - administration & dosage Taxoids - adverse effects Treatment Outcome |
| title | Colonic Rupture in a Patient on Combination Chemotherapy for Metastasized Carcinoma of the Esophagogastric Junction. Case Report and Review of the Literature |
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