Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. Contribution of two new cases
The autoimmune hepatitis (AIH)-primary biliary cirrhosis (PBC) overlap syndrome is characterized for clinical, biochemical, immunological, and histological features overlapping those of AIH and PBC, whose pathogenesis and more appropriate treatment are unknown at present. We describe two new patient...
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| Veröffentlicht in: | Anales de medicina interna (Madrid, Spain : 1984) Spain : 1984), 2005-03, Vol.22 (3), p.136 |
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| container_title | Anales de medicina interna (Madrid, Spain : 1984) |
| container_volume | 22 |
| creator | Fernández Fernández, F J de la Fuente Aguado, J Pérez Fernández, S Sopeña Pérez-Argüelles, B Nodar Germiñas, A Butrón Vila, M |
| description | The autoimmune hepatitis (AIH)-primary biliary cirrhosis (PBC) overlap syndrome is characterized for clinical, biochemical, immunological, and histological features overlapping those of AIH and PBC, whose pathogenesis and more appropriate treatment are unknown at present. We describe two new patients of this entity, which made debut with cholestasic acute hepatitis accompanied of hypergammaglobulinemia. In the first patient was demonstrated the presence of AMA, ASMA, and anti-LKM1 autoantibodies; and ANA in the second one. The histological findings showed changes suggestive of AIH and PBC. After the start of immunosuppressive treatment, associated to ursodeoxycholic acid in one patient, a successful outcome was observed. |
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Contribution of two new cases</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Fernández Fernández, F J ; de la Fuente Aguado, J ; Pérez Fernández, S ; Sopeña Pérez-Argüelles, B ; Nodar Germiñas, A ; Butrón Vila, M</creator><creatorcontrib>Fernández Fernández, F J ; de la Fuente Aguado, J ; Pérez Fernández, S ; Sopeña Pérez-Argüelles, B ; Nodar Germiñas, A ; Butrón Vila, M</creatorcontrib><description>The autoimmune hepatitis (AIH)-primary biliary cirrhosis (PBC) overlap syndrome is characterized for clinical, biochemical, immunological, and histological features overlapping those of AIH and PBC, whose pathogenesis and more appropriate treatment are unknown at present. We describe two new patients of this entity, which made debut with cholestasic acute hepatitis accompanied of hypergammaglobulinemia. In the first patient was demonstrated the presence of AMA, ASMA, and anti-LKM1 autoantibodies; and ANA in the second one. The histological findings showed changes suggestive of AIH and PBC. After the start of immunosuppressive treatment, associated to ursodeoxycholic acid in one patient, a successful outcome was observed.</description><identifier>ISSN: 0212-7199</identifier><identifier>PMID: 15839824</identifier><language>spa</language><publisher>Spain</publisher><subject>Adult ; Aged ; Female ; Hepatitis, Autoimmune - complications ; Hepatitis, Autoimmune - diagnosis ; Humans ; Liver Cirrhosis, Biliary - complications ; Liver Cirrhosis, Biliary - diagnosis</subject><ispartof>Anales de medicina interna (Madrid, Spain : 1984), 2005-03, Vol.22 (3), p.136</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15839824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández Fernández, F J</creatorcontrib><creatorcontrib>de la Fuente Aguado, J</creatorcontrib><creatorcontrib>Pérez Fernández, S</creatorcontrib><creatorcontrib>Sopeña Pérez-Argüelles, B</creatorcontrib><creatorcontrib>Nodar Germiñas, A</creatorcontrib><creatorcontrib>Butrón Vila, M</creatorcontrib><title>Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. Contribution of two new cases</title><title>Anales de medicina interna (Madrid, Spain : 1984)</title><addtitle>An Med Interna</addtitle><description>The autoimmune hepatitis (AIH)-primary biliary cirrhosis (PBC) overlap syndrome is characterized for clinical, biochemical, immunological, and histological features overlapping those of AIH and PBC, whose pathogenesis and more appropriate treatment are unknown at present. We describe two new patients of this entity, which made debut with cholestasic acute hepatitis accompanied of hypergammaglobulinemia. In the first patient was demonstrated the presence of AMA, ASMA, and anti-LKM1 autoantibodies; and ANA in the second one. The histological findings showed changes suggestive of AIH and PBC. After the start of immunosuppressive treatment, associated to ursodeoxycholic acid in one patient, a successful outcome was observed.</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Hepatitis, Autoimmune - complications</subject><subject>Hepatitis, Autoimmune - diagnosis</subject><subject>Humans</subject><subject>Liver Cirrhosis, Biliary - complications</subject><subject>Liver Cirrhosis, Biliary - diagnosis</subject><issn>0212-7199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjjsOgkAUALfQCH6uYN4FMPyMS000lhbWmgWW8Az7yb5Fwu2NUWuraSaZmbEwTpM0OiRFEbAl0SOO0zzjfMGCZM-zgqd5yG4Xh0q4CSrs8c0anesMIUVi8AaVGrSETlrh0SOBeUrXCws06cYZJXdQGu0dVoNHo8G04EcDWo5QC5K0ZvNW9CQ3X67Y9nS8lufIDpWSzd1-6vffUPZXeAFXwkLy</recordid><startdate>200503</startdate><enddate>200503</enddate><creator>Fernández Fernández, F J</creator><creator>de la Fuente Aguado, J</creator><creator>Pérez Fernández, S</creator><creator>Sopeña Pérez-Argüelles, B</creator><creator>Nodar Germiñas, A</creator><creator>Butrón Vila, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200503</creationdate><title>Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. 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After the start of immunosuppressive treatment, associated to ursodeoxycholic acid in one patient, a successful outcome was observed.</abstract><cop>Spain</cop><pmid>15839824</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0212-7199 |
| ispartof | Anales de medicina interna (Madrid, Spain : 1984), 2005-03, Vol.22 (3), p.136 |
| issn | 0212-7199 |
| language | spa |
| recordid | cdi_pubmed_primary_15839824 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Female Hepatitis, Autoimmune - complications Hepatitis, Autoimmune - diagnosis Humans Liver Cirrhosis, Biliary - complications Liver Cirrhosis, Biliary - diagnosis |
| title | Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. Contribution of two new cases |
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