Effect of Formaldehyde Gas Exposure in a Murine Allergic Contact Hypersensitivity Model
To clarify the effect of formaldehyde (FA) gas exposure on and contact hypersensitivity (CHS), CHS reactions against 2,4,6-trinitrochlorobenzene (TNCB) was studied in BALB/c mice with a low dose of FA gas exposure. The TNCB-induced CHS reactions were slightly suppressed by the FA gas exposure immedi...
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| Veröffentlicht in: | Immunopharmacology and immunotoxicology 2005, Vol.27 (1), p.163-175 |
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| creator | Fujii, Kazuyasu Tsuji, Kazuhide Matsuura, Hironori Okazaki, Fusako Takahashi, Sachiko Arata, Jirô Iwatsuki, Keiji |
| description | To clarify the effect of formaldehyde (FA) gas exposure on and contact hypersensitivity (CHS), CHS reactions against 2,4,6-trinitrochlorobenzene (TNCB) was studied in BALB/c mice with a low dose of FA gas exposure. The TNCB-induced CHS reactions were slightly suppressed by the FA gas exposure immediately after sensitization, whereas they were significantly enhanced and prolonged in mice continuously exposed to FA gas before and after sensitization. We showed that exposure to FA gas enhanced the Th2 dominant responses in draining lymph node (LN) in early stage of CHS. In contrast, T cell subsets and their intracellular cytokine production in the draining LN were similar during the early stage of CHS by FA gas exposure during the sensitization phase. The percentage of CD8+ T cells was increased, and the percentage of CD4+CD25+ T cells was decreased in the FA gas-exposed group at 72 hr after elicitation. These results indicate that FA gas-exposed might influence regulatory T cells. Furthermore, in the chronic CHS model that was repetitively elicited with TNCB, more intensive and prolonged CHS reactions, and increased numbers of mast cells were found in the FA gas-exposed group at 4 hr after elicitation than in the control group, FA gas exposure may alter the intensity of allergic CHS. |
| doi_str_mv | 10.1081/IPH-51768 |
| format | Article |
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The TNCB-induced CHS reactions were slightly suppressed by the FA gas exposure immediately after sensitization, whereas they were significantly enhanced and prolonged in mice continuously exposed to FA gas before and after sensitization. We showed that exposure to FA gas enhanced the Th2 dominant responses in draining lymph node (LN) in early stage of CHS. In contrast, T cell subsets and their intracellular cytokine production in the draining LN were similar during the early stage of CHS by FA gas exposure during the sensitization phase. The percentage of CD8+ T cells was increased, and the percentage of CD4+CD25+ T cells was decreased in the FA gas-exposed group at 72 hr after elicitation. These results indicate that FA gas-exposed might influence regulatory T cells. Furthermore, in the chronic CHS model that was repetitively elicited with TNCB, more intensive and prolonged CHS reactions, and increased numbers of mast cells were found in the FA gas-exposed group at 4 hr after elicitation than in the control group, FA gas exposure may alter the intensity of allergic CHS.</description><identifier>ISSN: 0892-3973</identifier><identifier>EISSN: 1532-2513</identifier><identifier>DOI: 10.1081/IPH-51768</identifier><identifier>PMID: 15803868</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Administration, Cutaneous ; Animals ; Contact hypersensitivity ; Dermatitis, Allergic Contact - immunology ; Dermatitis, Allergic Contact - pathology ; Dermatitis, Allergic Contact - prevention & control ; Disease Models, Animal ; Environmental Exposure - adverse effects ; Female ; Formaldehyde - administration & dosage ; Formaldehyde - toxicity ; Formaldehyde gas exposure ; Gases - administration & dosage ; Gases - toxicity ; Hypersensitivity, Delayed - immunology ; Lymph Nodes - drug effects ; Lymph Nodes - immunology ; Lymph Nodes - pathology ; Mice ; Mice, Inbred BALB C ; Picryl Chloride - administration & dosage ; Picryl Chloride - immunology ; Sick-building syndrome ; Th2 Cells - drug effects ; Th2 Cells - immunology</subject><ispartof>Immunopharmacology and immunotoxicology, 2005, Vol.27 (1), p.163-175</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3228-e7ddfdf3ac18283fd456e24bd758cb7270c7052a5cf0da4d617ece9a8c2a52493</citedby><cites>FETCH-LOGICAL-c3228-e7ddfdf3ac18283fd456e24bd758cb7270c7052a5cf0da4d617ece9a8c2a52493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1081/IPH-51768$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1081/IPH-51768$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4023,27922,27923,27924,59646,59752,60435,60541,61220,61255,61401,61436</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15803868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujii, Kazuyasu</creatorcontrib><creatorcontrib>Tsuji, Kazuhide</creatorcontrib><creatorcontrib>Matsuura, Hironori</creatorcontrib><creatorcontrib>Okazaki, Fusako</creatorcontrib><creatorcontrib>Takahashi, Sachiko</creatorcontrib><creatorcontrib>Arata, Jirô</creatorcontrib><creatorcontrib>Iwatsuki, Keiji</creatorcontrib><title>Effect of Formaldehyde Gas Exposure in a Murine Allergic Contact Hypersensitivity Model</title><title>Immunopharmacology and immunotoxicology</title><addtitle>Immunopharmacol Immunotoxicol</addtitle><description>To clarify the effect of formaldehyde (FA) gas exposure on and contact hypersensitivity (CHS), CHS reactions against 2,4,6-trinitrochlorobenzene (TNCB) was studied in BALB/c mice with a low dose of FA gas exposure. The TNCB-induced CHS reactions were slightly suppressed by the FA gas exposure immediately after sensitization, whereas they were significantly enhanced and prolonged in mice continuously exposed to FA gas before and after sensitization. We showed that exposure to FA gas enhanced the Th2 dominant responses in draining lymph node (LN) in early stage of CHS. In contrast, T cell subsets and their intracellular cytokine production in the draining LN were similar during the early stage of CHS by FA gas exposure during the sensitization phase. The percentage of CD8+ T cells was increased, and the percentage of CD4+CD25+ T cells was decreased in the FA gas-exposed group at 72 hr after elicitation. These results indicate that FA gas-exposed might influence regulatory T cells. Furthermore, in the chronic CHS model that was repetitively elicited with TNCB, more intensive and prolonged CHS reactions, and increased numbers of mast cells were found in the FA gas-exposed group at 4 hr after elicitation than in the control group, FA gas exposure may alter the intensity of allergic CHS.</description><subject>Administration, Cutaneous</subject><subject>Animals</subject><subject>Contact hypersensitivity</subject><subject>Dermatitis, Allergic Contact - immunology</subject><subject>Dermatitis, Allergic Contact - pathology</subject><subject>Dermatitis, Allergic Contact - prevention & control</subject><subject>Disease Models, Animal</subject><subject>Environmental Exposure - adverse effects</subject><subject>Female</subject><subject>Formaldehyde - administration & dosage</subject><subject>Formaldehyde - toxicity</subject><subject>Formaldehyde gas exposure</subject><subject>Gases - administration & dosage</subject><subject>Gases - toxicity</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Lymph Nodes - drug effects</subject><subject>Lymph Nodes - immunology</subject><subject>Lymph Nodes - pathology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Picryl Chloride - administration & dosage</subject><subject>Picryl Chloride - immunology</subject><subject>Sick-building syndrome</subject><subject>Th2 Cells - drug effects</subject><subject>Th2 Cells - immunology</subject><issn>0892-3973</issn><issn>1532-2513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtKAzEUhoMotlYXvoBk62I0l7lklqX0BhZdKC6HNDmxKdPJkMyo8_ZObUGErg4cvv_nnA-hW0oeKBH0cfmyiBKapeIMDWnCWcQSys_RkIicRTzP-ABdhbAlhOYZSS7RgCaCcJGKIXqfGgOqwc7gmfM7WWrYdBrwXAY8_a5daD1gW2GJV623FeBxWYL_sApPXNXIPrnoavABqmAb-2mbDq-chvIaXRhZBrg5zhF6m01fJ4vo6Xm-nIyfIsUZExFkWhttuFRUMMGNjpMUWLzWWSLUOmMZUf3FTCbKEC1jndIMFORSqH7H4pyP0P2hV3kXggdT1N7upO8KSoq9nKKXU_zK6dm7A1u36x3oP_JoowfiA2Ars5fx5Xypi0Z2pfPGy0rZUPBTvfxfbAOybDZKeii2rvVV__-Ja34A2SCC9w</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Fujii, Kazuyasu</creator><creator>Tsuji, Kazuhide</creator><creator>Matsuura, Hironori</creator><creator>Okazaki, Fusako</creator><creator>Takahashi, Sachiko</creator><creator>Arata, Jirô</creator><creator>Iwatsuki, Keiji</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2005</creationdate><title>Effect of Formaldehyde Gas Exposure in a Murine Allergic Contact Hypersensitivity Model</title><author>Fujii, Kazuyasu ; Tsuji, Kazuhide ; Matsuura, Hironori ; Okazaki, Fusako ; Takahashi, Sachiko ; Arata, Jirô ; Iwatsuki, Keiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3228-e7ddfdf3ac18283fd456e24bd758cb7270c7052a5cf0da4d617ece9a8c2a52493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Administration, Cutaneous</topic><topic>Animals</topic><topic>Contact hypersensitivity</topic><topic>Dermatitis, Allergic Contact - immunology</topic><topic>Dermatitis, Allergic Contact - pathology</topic><topic>Dermatitis, Allergic Contact - prevention & control</topic><topic>Disease Models, Animal</topic><topic>Environmental Exposure - adverse effects</topic><topic>Female</topic><topic>Formaldehyde - administration & dosage</topic><topic>Formaldehyde - toxicity</topic><topic>Formaldehyde gas exposure</topic><topic>Gases - administration & dosage</topic><topic>Gases - toxicity</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Lymph Nodes - drug effects</topic><topic>Lymph Nodes - immunology</topic><topic>Lymph Nodes - pathology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Picryl Chloride - administration & dosage</topic><topic>Picryl Chloride - immunology</topic><topic>Sick-building syndrome</topic><topic>Th2 Cells - drug effects</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujii, Kazuyasu</creatorcontrib><creatorcontrib>Tsuji, Kazuhide</creatorcontrib><creatorcontrib>Matsuura, Hironori</creatorcontrib><creatorcontrib>Okazaki, Fusako</creatorcontrib><creatorcontrib>Takahashi, Sachiko</creatorcontrib><creatorcontrib>Arata, Jirô</creatorcontrib><creatorcontrib>Iwatsuki, Keiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Immunopharmacology and immunotoxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujii, Kazuyasu</au><au>Tsuji, Kazuhide</au><au>Matsuura, Hironori</au><au>Okazaki, Fusako</au><au>Takahashi, Sachiko</au><au>Arata, Jirô</au><au>Iwatsuki, Keiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Formaldehyde Gas Exposure in a Murine Allergic Contact Hypersensitivity Model</atitle><jtitle>Immunopharmacology and immunotoxicology</jtitle><addtitle>Immunopharmacol Immunotoxicol</addtitle><date>2005</date><risdate>2005</risdate><volume>27</volume><issue>1</issue><spage>163</spage><epage>175</epage><pages>163-175</pages><issn>0892-3973</issn><eissn>1532-2513</eissn><abstract>To clarify the effect of formaldehyde (FA) gas exposure on and contact hypersensitivity (CHS), CHS reactions against 2,4,6-trinitrochlorobenzene (TNCB) was studied in BALB/c mice with a low dose of FA gas exposure. The TNCB-induced CHS reactions were slightly suppressed by the FA gas exposure immediately after sensitization, whereas they were significantly enhanced and prolonged in mice continuously exposed to FA gas before and after sensitization. We showed that exposure to FA gas enhanced the Th2 dominant responses in draining lymph node (LN) in early stage of CHS. In contrast, T cell subsets and their intracellular cytokine production in the draining LN were similar during the early stage of CHS by FA gas exposure during the sensitization phase. The percentage of CD8+ T cells was increased, and the percentage of CD4+CD25+ T cells was decreased in the FA gas-exposed group at 72 hr after elicitation. These results indicate that FA gas-exposed might influence regulatory T cells. Furthermore, in the chronic CHS model that was repetitively elicited with TNCB, more intensive and prolonged CHS reactions, and increased numbers of mast cells were found in the FA gas-exposed group at 4 hr after elicitation than in the control group, FA gas exposure may alter the intensity of allergic CHS.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>15803868</pmid><doi>10.1081/IPH-51768</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Administration, Cutaneous Animals Contact hypersensitivity Dermatitis, Allergic Contact - immunology Dermatitis, Allergic Contact - pathology Dermatitis, Allergic Contact - prevention & control Disease Models, Animal Environmental Exposure - adverse effects Female Formaldehyde - administration & dosage Formaldehyde - toxicity Formaldehyde gas exposure Gases - administration & dosage Gases - toxicity Hypersensitivity, Delayed - immunology Lymph Nodes - drug effects Lymph Nodes - immunology Lymph Nodes - pathology Mice Mice, Inbred BALB C Picryl Chloride - administration & dosage Picryl Chloride - immunology Sick-building syndrome Th2 Cells - drug effects Th2 Cells - immunology |
| title | Effect of Formaldehyde Gas Exposure in a Murine Allergic Contact Hypersensitivity Model |
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