A case of vanishing bile duct syndrome associated with hypersensitivity to allopurinol

Allopurinol is frequently used for the treatment of hyperuricemia and gout. Sometimes, a life-threatening reaction develops, as is illustrated by the following case report. We describe a 60-year-old male patient who was treated with allopurinol because of asymptomatic hyperuricemia, and he was prese...

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Veröffentlicht in:The Korean journal of hepatology 2005-03, Vol.11 (1), p.80
Hauptverfasser: Choi, Seong Ho, Yang, Soo Hyun, Song, Young Bong, Kim, Hye Jin, Seo, Yeoung Tae, Choi, Dong Seog, Moon, Kyoung Hyoub, Byun, Jong Hoon, Yu, Eun Sil
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container_issue 1
container_start_page 80
container_title The Korean journal of hepatology
container_volume 11
creator Choi, Seong Ho
Yang, Soo Hyun
Song, Young Bong
Kim, Hye Jin
Seo, Yeoung Tae
Choi, Dong Seog
Moon, Kyoung Hyoub
Byun, Jong Hoon
Yu, Eun Sil
description Allopurinol is frequently used for the treatment of hyperuricemia and gout. Sometimes, a life-threatening reaction develops, as is illustrated by the following case report. We describe a 60-year-old male patient who was treated with allopurinol because of asymptomatic hyperuricemia, and he was presented with fever, skin rash, eosinophilia, worsening renal function and vanishing bile duct syndrome. In this report, we discussed vanishing bile duct syndrome as a serious side effect of allopurinol, and we briefly reviewed the etiology, prevention, and treatment modalities for vanishing bile duct syndrome.
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subjects Allopurinol - adverse effects
Bile Duct Diseases - etiology
Bile Duct Diseases - pathology
Drug Hypersensitivity - complications
Gout Suppressants - adverse effects
Humans
Male
Middle Aged
title A case of vanishing bile duct syndrome associated with hypersensitivity to allopurinol
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