Microphthalmia transcription factor: a specific marker for malignant melanoma
The transcription factor microphthalmia (MITF) is required for the formation of normal melanocytes during embryonic development and for the expression of pigment cell-specific markers, which are the downstream transcriptional targets of MITF. It also seems to be crucial for the survival of malignant...
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| Veröffentlicht in: | Prague medical report 2004, Vol.105 (3), p.318 |
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| creator | Vachtenheim, J Borovanský, J |
| description | The transcription factor microphthalmia (MITF) is required for the formation of normal melanocytes during embryonic development and for the expression of pigment cell-specific markers, which are the downstream transcriptional targets of MITF. It also seems to be crucial for the survival of malignant melanocytes. The special interest of this review is the possible utility of MITF as a marker of malignant melanoma. Melanocyte-specific isoform of MITF appears to be a unique molecule in the differential diagnosis of melanocytic tumors. |
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It also seems to be crucial for the survival of malignant melanocytes. The special interest of this review is the possible utility of MITF as a marker of malignant melanoma. Melanocyte-specific isoform of MITF appears to be a unique molecule in the differential diagnosis of melanocytic tumors.</description><identifier>ISSN: 1214-6994</identifier><identifier>PMID: 15782558</identifier><language>eng</language><publisher>Czech Republic</publisher><subject>Biomarkers, Tumor - analysis ; DNA-Binding Proteins - analysis ; Genetic Markers ; Humans ; Immunohistochemistry ; Melanoma - diagnosis ; Melanoma - genetics ; Microphthalmia-Associated Transcription Factor ; Skin Neoplasms - diagnosis ; Skin Neoplasms - genetics ; Transcription Factors - analysis</subject><ispartof>Prague medical report, 2004, Vol.105 (3), p.318</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15782558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vachtenheim, J</creatorcontrib><creatorcontrib>Borovanský, J</creatorcontrib><title>Microphthalmia transcription factor: a specific marker for malignant melanoma</title><title>Prague medical report</title><addtitle>Prague Med Rep</addtitle><description>The transcription factor microphthalmia (MITF) is required for the formation of normal melanocytes during embryonic development and for the expression of pigment cell-specific markers, which are the downstream transcriptional targets of MITF. It also seems to be crucial for the survival of malignant melanocytes. The special interest of this review is the possible utility of MITF as a marker of malignant melanoma. Melanocyte-specific isoform of MITF appears to be a unique molecule in the differential diagnosis of melanocytic tumors.</description><subject>Biomarkers, Tumor - analysis</subject><subject>DNA-Binding Proteins - analysis</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - genetics</subject><subject>Microphthalmia-Associated Transcription Factor</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - genetics</subject><subject>Transcription Factors - analysis</subject><issn>1214-6994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j0lOAzEURL0AkSjkCpEv0JLn72aHIiYpEZvso98eiEMPltssuD0tAbWptyq9uiFrLrhqTNuqFdnO85Ut0coAiDuy4hqs0NquyfGYXJnypV6wHxLSWnCcXUm5pmmkEV2dygNFOufgUkyODlg-Q6FxKgv26WPEsdIh9DhOA96T24j9HLZ_vSGn56fT_rU5vL-87R8PTW5lbTqpNVonO7AYLBMcQLrILQRlopdSCGYYANPMeAPKcWOF5-gZU-CtcHJDdr-z-asbgj_nkhat7_P_LfkDR3FI_g</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Vachtenheim, J</creator><creator>Borovanský, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>2004</creationdate><title>Microphthalmia transcription factor: a specific marker for malignant melanoma</title><author>Vachtenheim, J ; Borovanský, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p93t-b355a8c3b78ae8021773cf187e46fd3322060770506d674c1682d1ad0047d82c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biomarkers, Tumor - analysis</topic><topic>DNA-Binding Proteins - analysis</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Melanoma - diagnosis</topic><topic>Melanoma - genetics</topic><topic>Microphthalmia-Associated Transcription Factor</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - genetics</topic><topic>Transcription Factors - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vachtenheim, J</creatorcontrib><creatorcontrib>Borovanský, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Prague medical report</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vachtenheim, J</au><au>Borovanský, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microphthalmia transcription factor: a specific marker for malignant melanoma</atitle><jtitle>Prague medical report</jtitle><addtitle>Prague Med Rep</addtitle><date>2004</date><risdate>2004</risdate><volume>105</volume><issue>3</issue><spage>318</spage><pages>318-</pages><issn>1214-6994</issn><abstract>The transcription factor microphthalmia (MITF) is required for the formation of normal melanocytes during embryonic development and for the expression of pigment cell-specific markers, which are the downstream transcriptional targets of MITF. It also seems to be crucial for the survival of malignant melanocytes. The special interest of this review is the possible utility of MITF as a marker of malignant melanoma. Melanocyte-specific isoform of MITF appears to be a unique molecule in the differential diagnosis of melanocytic tumors.</abstract><cop>Czech Republic</cop><pmid>15782558</pmid></addata></record> |
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| identifier | ISSN: 1214-6994 |
| ispartof | Prague medical report, 2004, Vol.105 (3), p.318 |
| issn | 1214-6994 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biomarkers, Tumor - analysis DNA-Binding Proteins - analysis Genetic Markers Humans Immunohistochemistry Melanoma - diagnosis Melanoma - genetics Microphthalmia-Associated Transcription Factor Skin Neoplasms - diagnosis Skin Neoplasms - genetics Transcription Factors - analysis |
| title | Microphthalmia transcription factor: a specific marker for malignant melanoma |
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