Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase

Apolipoprotein A5 (APOA5) is associated with differences in triglyceride levels and familial combined hyperlipidemia. In genetically engineered mice, apoAV plasma levels are inversely correlated with plasma triglycerides. To elucidate the mechanism by which apoAV influences plasma triglycerides, met...

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Veröffentlicht in:	The Journal of biological chemistry 2005-06, Vol.280 (22), p.21553
Hauptverfasser:	Merkel, Martin, Loeffler, Britta, Kluger, Malte, Fabig, Nathalie, Geppert, Gesa, Pennacchio, Len A, Laatsch, Alexander, Heeren, Joerg
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Site Animals Apolipoprotein A-V Apolipoproteins - metabolism Apolipoproteins - physiology Apolipoproteins A Blotting, Western CHO Cells Chylomicrons - metabolism Cricetinae Dose-Response Relationship, Drug Genotype Heparin - chemistry Humans Hydrolysis Ligands Lipids - chemistry Lipoprotein Lipase - chemistry Lipoproteins - chemistry Lipoproteins, VLDL - metabolism Mice Mice, Transgenic Protein Binding Proteoglycans - chemistry Recombinant Proteins - chemistry Time Factors Triglycerides - chemistry Triglycerides - metabolism
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