Specific interaction of VEGF165 with β‐amyloid, and its protective effect on β‐amyloid‐induced neurotoxicity

β‐amyloid (Aβ) is a major component of senile plaques that is commonly found in the brain of Alzheimer's disease (AD) patient. In the previous report, we showed that an important angiogenic factor, vascular endothelial growth factor (VEGF) interacts with Aβ and is accumulated in the senile plaq...

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Veröffentlicht in:	Journal of neurochemistry 2005-04, Vol.93 (1), p.118-127
Hauptverfasser:	Yang, Seung‐Pil, Kwon, Byoung‐Oh, Gho, Yong Song, Chae, Chi‐Bom
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid beta-Peptides - metabolism Animals Binding Sites Biological and medical sciences Carrier Proteins - metabolism Cell Survival - drug effects Cytokines - metabolism cytotoxicity Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dose-Response Relationship, Drug heparin‐binding domain Humans Medical sciences Neurology Neuropharmacology Neuroprotective agent PC12 Cells - drug effects Peptide Fragments Pharmacology. Drug treatments Protein Binding Protein Isoforms - metabolism Rats reactive oxygen species Recombinant Proteins - metabolism Sequence Homology, Amino Acid Surface Plasmon Resonance - methods Time Factors vascular endothelial growth factor Vascular Endothelial Growth Factor A - chemistry Vascular Endothelial Growth Factor A - metabolism β‐amyloid
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