Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue
High dose acetaminophen (HDAC) with N‐acetylcysteine (NAC) has been effective in adults with advanced malignancies. We report HDAC with NAC in a child with progressive hepatoblastoma, confirmed at biopsy of an unresectable hepatic mass. Alpha‐fetoprotein (AFP) increased despite four courses of doxor...
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| Veröffentlicht in: | Pediatric blood & cancer 2005-08, Vol.45 (2), p.222-225 |
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| container_title | Pediatric blood & cancer |
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| creator | Kobrinsky, Nathan L. Sjolander, Diane E. Goldenberg, Jacob A. Ortmeier, Thomas C. |
| description | High dose acetaminophen (HDAC) with N‐acetylcysteine (NAC) has been effective in adults with advanced malignancies. We report HDAC with NAC in a child with progressive hepatoblastoma, confirmed at biopsy of an unresectable hepatic mass. Alpha‐fetoprotein (AFP) increased despite four courses of doxorubicin and one course of cisplatin, 5‐flurouracil, and vincristine. Following HDAC with NAC, AFP markedly decreased. A continued response without toxicity was observed during four subsequent courses of HDAC with NAC and cisplatin. The residual necrotic tumor was resected. The child is now over 8 years disease free. HDAC and NAC are effective and well tolerated for progressive hepatoblastoma. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/pbc.20330 |
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We report HDAC with NAC in a child with progressive hepatoblastoma, confirmed at biopsy of an unresectable hepatic mass. Alpha‐fetoprotein (AFP) increased despite four courses of doxorubicin and one course of cisplatin, 5‐flurouracil, and vincristine. Following HDAC with NAC, AFP markedly decreased. A continued response without toxicity was observed during four subsequent courses of HDAC with NAC and cisplatin. The residual necrotic tumor was resected. The child is now over 8 years disease free. HDAC and NAC are effective and well tolerated for progressive hepatoblastoma. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 1545-5009</identifier><identifier>EISSN: 1545-5017</identifier><identifier>DOI: 10.1002/pbc.20330</identifier><identifier>PMID: 15770640</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>acetaminophen ; Acetaminophen - administration & dosage ; Acetylcysteine - therapeutic use ; Antineoplastic Agents - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - pharmacology ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Beckwith-Wiedemann ; Beckwith-Wiedemann Syndrome - complications ; Biological and medical sciences ; Cisplatin - administration & dosage ; Cisplatin - pharmacology ; cisplatin-resistance ; Doxorubicin - pharmacology ; doxorubicin-resistance ; Drug Resistance, Neoplasm ; Drug Therapy, Combination ; Female ; General aspects ; hepatoblastoma ; Hepatoblastoma - complications ; Hepatoblastoma - drug therapy ; Hepatoblastoma - pathology ; Humans ; Infant ; Liver Neoplasms - complications ; Liver Neoplasms - drug therapy ; Liver Neoplasms - pathology ; Medical sciences ; N-acetylcysteine ; Tumors</subject><ispartof>Pediatric blood & cancer, 2005-08, Vol.45 (2), p.222-225</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3570-347573e4abf28cb0eddf573955ee88ec21983c8bd0d9fd84066f77c57de3f8263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpbc.20330$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpbc.20330$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16971577$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15770640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobrinsky, Nathan L.</creatorcontrib><creatorcontrib>Sjolander, Diane E.</creatorcontrib><creatorcontrib>Goldenberg, Jacob A.</creatorcontrib><creatorcontrib>Ortmeier, Thomas C.</creatorcontrib><title>Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue</title><title>Pediatric blood & cancer</title><addtitle>Pediatr. Blood Cancer</addtitle><description>High dose acetaminophen (HDAC) with N‐acetylcysteine (NAC) has been effective in adults with advanced malignancies. We report HDAC with NAC in a child with progressive hepatoblastoma, confirmed at biopsy of an unresectable hepatic mass. Alpha‐fetoprotein (AFP) increased despite four courses of doxorubicin and one course of cisplatin, 5‐flurouracil, and vincristine. Following HDAC with NAC, AFP markedly decreased. A continued response without toxicity was observed during four subsequent courses of HDAC with NAC and cisplatin. The residual necrotic tumor was resected. The child is now over 8 years disease free. HDAC and NAC are effective and well tolerated for progressive hepatoblastoma. © 2005 Wiley‐Liss, Inc.</description><subject>acetaminophen</subject><subject>Acetaminophen - administration & dosage</subject><subject>Acetylcysteine - therapeutic use</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - pharmacology</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Beckwith-Wiedemann</subject><subject>Beckwith-Wiedemann Syndrome - complications</subject><subject>Biological and medical sciences</subject><subject>Cisplatin - administration & dosage</subject><subject>Cisplatin - pharmacology</subject><subject>cisplatin-resistance</subject><subject>Doxorubicin - pharmacology</subject><subject>doxorubicin-resistance</subject><subject>Drug Resistance, Neoplasm</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>General aspects</subject><subject>hepatoblastoma</subject><subject>Hepatoblastoma - complications</subject><subject>Hepatoblastoma - drug therapy</subject><subject>Hepatoblastoma - pathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - pathology</subject><subject>Medical sciences</subject><subject>N-acetylcysteine</subject><subject>Tumors</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1O3TAUhC3UqlDaBS9QedNlwInjOFmWK6D8CK4EFUvLsY8bl8SJYkeQp-IVcQiFlcfH33ikMwgdpOQwJSQ7Gmp1mBFKyQ7aS1nOEkZS_uldk2oXffX-X0QLwsovaDdlnJMiJ3vo-XZSCrw3U4vDCDJ04ALuDdb9Uz9OtVXWYek0VtYPrQzxNoK3PsiINTDI0Net9KHvJF5IrBrbavxoQ4OPQT0sIrm3oKGTzmE_Oz32HaxAY_82McgDlgqC7KzrhwbWvOtkmc2tmn0A62CJVRN8Q5-NbD18fzv30Z_Tk7vN7-Tq5ux88-sqUZRxktCcM04hl7XJSlUT0NrEQcUYQFmCytKqpKqsNdGV0WVOisJwrhjXQE2ZFXQf_Vj_Haa6Ay2G0XZynMX_zUXg5xsgvZKtGaWLK_rgioovbOSOVu7RtjB_vBOxVCdideK1OrE93ryK6EhWR9wyPL075PggCk45E_fXZ2Jzcbm9K7ZbkdMXMcCfSw</recordid><startdate>200508</startdate><enddate>200508</enddate><creator>Kobrinsky, Nathan L.</creator><creator>Sjolander, Diane E.</creator><creator>Goldenberg, Jacob A.</creator><creator>Ortmeier, Thomas C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200508</creationdate><title>Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue</title><author>Kobrinsky, Nathan L. ; Sjolander, Diane E. ; Goldenberg, Jacob A. ; Ortmeier, Thomas C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3570-347573e4abf28cb0eddf573955ee88ec21983c8bd0d9fd84066f77c57de3f8263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>acetaminophen</topic><topic>Acetaminophen - administration & dosage</topic><topic>Acetylcysteine - therapeutic use</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Combined Chemotherapy Protocols - pharmacology</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Beckwith-Wiedemann</topic><topic>Beckwith-Wiedemann Syndrome - complications</topic><topic>Biological and medical sciences</topic><topic>Cisplatin - administration & dosage</topic><topic>Cisplatin - pharmacology</topic><topic>cisplatin-resistance</topic><topic>Doxorubicin - pharmacology</topic><topic>doxorubicin-resistance</topic><topic>Drug Resistance, Neoplasm</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>General aspects</topic><topic>hepatoblastoma</topic><topic>Hepatoblastoma - complications</topic><topic>Hepatoblastoma - drug therapy</topic><topic>Hepatoblastoma - pathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Liver Neoplasms - complications</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - pathology</topic><topic>Medical sciences</topic><topic>N-acetylcysteine</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobrinsky, Nathan L.</creatorcontrib><creatorcontrib>Sjolander, Diane E.</creatorcontrib><creatorcontrib>Goldenberg, Jacob A.</creatorcontrib><creatorcontrib>Ortmeier, Thomas C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Pediatric blood & cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobrinsky, Nathan L.</au><au>Sjolander, Diane E.</au><au>Goldenberg, Jacob A.</au><au>Ortmeier, Thomas C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue</atitle><jtitle>Pediatric blood & cancer</jtitle><addtitle>Pediatr. Blood Cancer</addtitle><date>2005-08</date><risdate>2005</risdate><volume>45</volume><issue>2</issue><spage>222</spage><epage>225</epage><pages>222-225</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><abstract>High dose acetaminophen (HDAC) with N‐acetylcysteine (NAC) has been effective in adults with advanced malignancies. We report HDAC with NAC in a child with progressive hepatoblastoma, confirmed at biopsy of an unresectable hepatic mass. Alpha‐fetoprotein (AFP) increased despite four courses of doxorubicin and one course of cisplatin, 5‐flurouracil, and vincristine. Following HDAC with NAC, AFP markedly decreased. A continued response without toxicity was observed during four subsequent courses of HDAC with NAC and cisplatin. The residual necrotic tumor was resected. The child is now over 8 years disease free. HDAC and NAC are effective and well tolerated for progressive hepatoblastoma. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15770640</pmid><doi>10.1002/pbc.20330</doi><tpages>4</tpages></addata></record> |
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| subjects | acetaminophen Acetaminophen - administration & dosage Acetylcysteine - therapeutic use Antineoplastic Agents - administration & dosage Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Beckwith-Wiedemann Beckwith-Wiedemann Syndrome - complications Biological and medical sciences Cisplatin - administration & dosage Cisplatin - pharmacology cisplatin-resistance Doxorubicin - pharmacology doxorubicin-resistance Drug Resistance, Neoplasm Drug Therapy, Combination Female General aspects hepatoblastoma Hepatoblastoma - complications Hepatoblastoma - drug therapy Hepatoblastoma - pathology Humans Infant Liver Neoplasms - complications Liver Neoplasms - drug therapy Liver Neoplasms - pathology Medical sciences N-acetylcysteine Tumors |
| title | Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue |
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