The role of interferon-gamma and vitamin-A in modulating telomerase activity in breast cancer patients

Telomerase is a ribonucloprotein enzyme that appears to play a role in carcinogenesis. To understand the regulatory mechanisms which govern telomerase activity, we used telomeric repeat amplification protocol (TRAP) to quantitate and compare telomerase activity in cultured peripheral blood mononucle...

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Veröffentlicht in:	The Egyptian journal of immunology 2003, Vol.10 (1), p.47
Hauptverfasser:	Hussein, Amina El-Sayed, El-Moneim, Nadia A Abd, Mahmoud, Mervat M, Abdel -Baky, Mostafa M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Breast Neoplasms - blood Breast Neoplasms - enzymology Breast Neoplasms - immunology Case-Control Studies Cells, Cultured Female Humans Interferon-gamma - antagonists & inhibitors Interferon-gamma - blood Leukocytes, Mononuclear - enzymology Leukocytes, Mononuclear - immunology Middle Aged Telomerase - blood Vitamin A - blood
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Zusammenfassung:	Telomerase is a ribonucloprotein enzyme that appears to play a role in carcinogenesis. To understand the regulatory mechanisms which govern telomerase activity, we used telomeric repeat amplification protocol (TRAP) to quantitate and compare telomerase activity in cultured peripheral blood mononuclear cells (PBMCs) with and without INF-gamma in breast cancer patients. Serum levels of IFN-gamma and vitamin-A were also measured to look for a possible influence of these chemotherapeutic agents on telomerase activity. 23 premenopausal breast carcinoma patients (8 with clinical stage 11, 8 stage III and 7 stage IV) and ten age and menstrual stage matched healthy controls were studied. Before surgery, telomerase activity and IFN-gamma levels were significantly higher (P
ISSN:	1110-4902