Simultaneous AMPA/kainate receptor blockade and dopamine D(2/3) receptor stimulation in the nucleus accumbens decreases brain stimulation reward in rats
Interactions between dopamine (DA) and glutamate (GLU) in the mesocorticolimbic pathway of the brain may influence motivation and reward. Previous work from this laboratory has demonstrated that alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor blockade may potentiate...
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| Veröffentlicht in: | Behavioural brain research 2005-03, Vol.158 (1), p.79 |
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| creator | Choi, Kwang-Ho Clements, Robert L H Greenshaw, Andrew J |
| description | Interactions between dopamine (DA) and glutamate (GLU) in the mesocorticolimbic pathway of the brain may influence motivation and reward. Previous work from this laboratory has demonstrated that alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor blockade may potentiate decreases in exploratory motor activity induced by the DA D(2/3) receptor agonist 7-OH-DPAT in the nucleus accumbens septi (NAS). This study investigated the interaction of AMPA/kainate receptor antagonists CNQX or NBQX with 7-OH-DPAT on ventral tegmental area (VTA) brain stimulation reward (BSR). Effects of these compounds, alone and combined, were measured in male Sprague-Dawley rats stereotaxically implanted with a unilateral VTA electrode and bilateral guide cannulae in the NAS core or shell subregions. Rate-frequency analysis was used to assess BSR frequency thresholds and maximum response rates of rats trained to lever-press for reinforcing electrical stimulation. When given alone, CNQX (0.5 microg), NBQX (0.5 microg), or 7-OH-DPAT (5.0 microg) did not affect BSR frequency thresholds. Co-administration of CNQX or NBQX with 7-OH-DPAT synergistically increased BSR frequency thresholds, indicative of decreased reward. These data indicate that simultaneous AMPA/kainate receptor blockade and DA D(2/3) receptor stimulation in the NAS may act synergistically to inhibit motivated behaviours such as electrical brain self-stimulation. |
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Previous work from this laboratory has demonstrated that alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor blockade may potentiate decreases in exploratory motor activity induced by the DA D(2/3) receptor agonist 7-OH-DPAT in the nucleus accumbens septi (NAS). This study investigated the interaction of AMPA/kainate receptor antagonists CNQX or NBQX with 7-OH-DPAT on ventral tegmental area (VTA) brain stimulation reward (BSR). Effects of these compounds, alone and combined, were measured in male Sprague-Dawley rats stereotaxically implanted with a unilateral VTA electrode and bilateral guide cannulae in the NAS core or shell subregions. Rate-frequency analysis was used to assess BSR frequency thresholds and maximum response rates of rats trained to lever-press for reinforcing electrical stimulation. When given alone, CNQX (0.5 microg), NBQX (0.5 microg), or 7-OH-DPAT (5.0 microg) did not affect BSR frequency thresholds. Co-administration of CNQX or NBQX with 7-OH-DPAT synergistically increased BSR frequency thresholds, indicative of decreased reward. These data indicate that simultaneous AMPA/kainate receptor blockade and DA D(2/3) receptor stimulation in the NAS may act synergistically to inhibit motivated behaviours such as electrical brain self-stimulation.</description><identifier>ISSN: 0166-4328</identifier><identifier>PMID: 15680196</identifier><language>eng</language><publisher>Netherlands</publisher><subject>6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology ; Analysis of Variance ; Animals ; Behavior, Animal ; Dopamine D2 Receptor Antagonists ; Dose-Response Relationship, Radiation ; Drug Interactions ; Electric Stimulation - methods ; Male ; Microinjections - methods ; Motor Activity - drug effects ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - physiology ; Quinoxalines - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA - antagonists & inhibitors ; Receptors, AMPA - physiology ; Receptors, Dopamine D2 - physiology ; Receptors, Kainic Acid - antagonists & inhibitors ; Receptors, Kainic Acid - physiology ; Regression Analysis ; Reward ; Tetrahydronaphthalenes - pharmacology ; Ventral Tegmental Area - physiology ; Ventral Tegmental Area - radiation effects</subject><ispartof>Behavioural brain research, 2005-03, Vol.158 (1), p.79</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15680196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Kwang-Ho</creatorcontrib><creatorcontrib>Clements, Robert L H</creatorcontrib><creatorcontrib>Greenshaw, Andrew J</creatorcontrib><title>Simultaneous AMPA/kainate receptor blockade and dopamine D(2/3) receptor stimulation in the nucleus accumbens decreases brain stimulation reward in rats</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>Interactions between dopamine (DA) and glutamate (GLU) in the mesocorticolimbic pathway of the brain may influence motivation and reward. Previous work from this laboratory has demonstrated that alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor blockade may potentiate decreases in exploratory motor activity induced by the DA D(2/3) receptor agonist 7-OH-DPAT in the nucleus accumbens septi (NAS). This study investigated the interaction of AMPA/kainate receptor antagonists CNQX or NBQX with 7-OH-DPAT on ventral tegmental area (VTA) brain stimulation reward (BSR). Effects of these compounds, alone and combined, were measured in male Sprague-Dawley rats stereotaxically implanted with a unilateral VTA electrode and bilateral guide cannulae in the NAS core or shell subregions. Rate-frequency analysis was used to assess BSR frequency thresholds and maximum response rates of rats trained to lever-press for reinforcing electrical stimulation. When given alone, CNQX (0.5 microg), NBQX (0.5 microg), or 7-OH-DPAT (5.0 microg) did not affect BSR frequency thresholds. Co-administration of CNQX or NBQX with 7-OH-DPAT synergistically increased BSR frequency thresholds, indicative of decreased reward. These data indicate that simultaneous AMPA/kainate receptor blockade and DA D(2/3) receptor stimulation in the NAS may act synergistically to inhibit motivated behaviours such as electrical brain self-stimulation.</description><subject>6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Dopamine D2 Receptor Antagonists</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Drug Interactions</subject><subject>Electric Stimulation - methods</subject><subject>Male</subject><subject>Microinjections - methods</subject><subject>Motor Activity - drug effects</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - physiology</subject><subject>Quinoxalines - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, AMPA - antagonists & inhibitors</subject><subject>Receptors, AMPA - physiology</subject><subject>Receptors, Dopamine D2 - physiology</subject><subject>Receptors, Kainic Acid - antagonists & inhibitors</subject><subject>Receptors, Kainic Acid - physiology</subject><subject>Regression Analysis</subject><subject>Reward</subject><subject>Tetrahydronaphthalenes - pharmacology</subject><subject>Ventral Tegmental Area - physiology</subject><subject>Ventral Tegmental Area - radiation effects</subject><issn>0166-4328</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1OwzAUhL0A0VK4AvISFlHtODbJMiq_UhFIdF89288QmjiR7QhxE45LKkCI1WxmvtHMAZkzrlRWiLyckeMY3xhjBZP8iMy4VCXjlZqTz-emG9sEHvsx0vrhqV7uoPGQkAY0OKQ-UN32ZgcWKXhLbT9A13ikV-f5Ulz8uWLakyA1vaeNp-kVqR9NixMWjBk7jT5SiyYgRIxUh6nmXyjgOwS7zwZI8YQcOmgjnv7ogmxurjeru2z9eHu_qtfZy2WlMlkwpio9jeFl6VBJw1UuykIxDoKjKp0xaJyzEqe9WueV1RV3ORqQorAgFuTsGzuMukO7HULTQfjY_j4kvgA3KWRV</recordid><startdate>20050307</startdate><enddate>20050307</enddate><creator>Choi, Kwang-Ho</creator><creator>Clements, Robert L H</creator><creator>Greenshaw, Andrew J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20050307</creationdate><title>Simultaneous AMPA/kainate receptor blockade and dopamine D(2/3) receptor stimulation in the nucleus accumbens decreases brain stimulation reward in rats</title><author>Choi, Kwang-Ho ; 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Previous work from this laboratory has demonstrated that alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor blockade may potentiate decreases in exploratory motor activity induced by the DA D(2/3) receptor agonist 7-OH-DPAT in the nucleus accumbens septi (NAS). This study investigated the interaction of AMPA/kainate receptor antagonists CNQX or NBQX with 7-OH-DPAT on ventral tegmental area (VTA) brain stimulation reward (BSR). Effects of these compounds, alone and combined, were measured in male Sprague-Dawley rats stereotaxically implanted with a unilateral VTA electrode and bilateral guide cannulae in the NAS core or shell subregions. Rate-frequency analysis was used to assess BSR frequency thresholds and maximum response rates of rats trained to lever-press for reinforcing electrical stimulation. When given alone, CNQX (0.5 microg), NBQX (0.5 microg), or 7-OH-DPAT (5.0 microg) did not affect BSR frequency thresholds. Co-administration of CNQX or NBQX with 7-OH-DPAT synergistically increased BSR frequency thresholds, indicative of decreased reward. These data indicate that simultaneous AMPA/kainate receptor blockade and DA D(2/3) receptor stimulation in the NAS may act synergistically to inhibit motivated behaviours such as electrical brain self-stimulation.</abstract><cop>Netherlands</cop><pmid>15680196</pmid></addata></record> |
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| subjects | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Analysis of Variance Animals Behavior, Animal Dopamine D2 Receptor Antagonists Dose-Response Relationship, Radiation Drug Interactions Electric Stimulation - methods Male Microinjections - methods Motor Activity - drug effects Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Quinoxalines - pharmacology Rats Rats, Sprague-Dawley Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - physiology Receptors, Dopamine D2 - physiology Receptors, Kainic Acid - antagonists & inhibitors Receptors, Kainic Acid - physiology Regression Analysis Reward Tetrahydronaphthalenes - pharmacology Ventral Tegmental Area - physiology Ventral Tegmental Area - radiation effects |
| title | Simultaneous AMPA/kainate receptor blockade and dopamine D(2/3) receptor stimulation in the nucleus accumbens decreases brain stimulation reward in rats |
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