Petasites hybridus extracts in vitro inhibit COX-2 and PGE2 release by direct interaction with the enzyme and by preventing p42/44 MAP kinase activation in rat primary microglial cells

Abstract Rhizomes of butterbur, PETASITES HYBRIDUS L. (Asteraceae), have been used since ancient times for the treatment of inflammatory diseases. In the present study, the effects of lipophilic extracts from rhizomes of PETASITES HYBRIDUS on the formation and release of prostaglandin E 2 were inves...

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Veröffentlicht in:	Planta medica 2005, Vol.71 (1), p.12-19
Hauptverfasser:	Fiebich, B.L, Grozdeva, M, Hess, S, Hull, M, Danesch, U, Bodensieck, A, Bauer, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asteraceae Biological and medical sciences cultured cells Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - administration & dosage Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase Inhibitors - therapeutic use Dinoprostone - metabolism Dose-Response Relationship, Drug enzyme activation Enzyme Activation - drug effects enzyme inhibitors General pharmacology Inhibitory Concentration 50 isopetasin Medical sciences medicinal plants medicinal properties Membrane Proteins Microglia - cytology Mitogen-Activated Protein Kinases - drug effects Mitogen-Activated Protein Kinases - metabolism mitogen-associated protein kinases neuroglia Original Paper petasin Petasites Petasites hybridus Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals Phytotherapy plant extracts Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use prostaglandin synthase Prostaglandin-Endoperoxide Synthases - drug effects Prostaglandin-Endoperoxide Synthases - metabolism prostaglandins protein kinases Rats Rats, Wistar sesquiterpenoids
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