Effect of Maternal Administration of Selective Cyclooxygenase (COX)-2 Inhibitors on Renal Size, Growth Factors, Proteinases, and COX-2 Secretion in the Fetal Rabbit

Background: Selective cyclooxygenase (COX)-2 inhibitors are currently being considered for management of preterm labor. COX-2 is an important regulator of fetal renal growth and function. Its inhibition may lead to congenital oligonephropathy. Objectives: We investigated whether maternal administrat...

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Veröffentlicht in:	Biology of the neonate 2005-01, Vol.87 (4), p.246-253
Hauptverfasser:	Hartleroad, Jeffrey Y., Beharry, Kay D., Hausman, Nicole, Stavitsky, Yuri, Asrat, Tamerou, Modanlou, Houchang D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Celecoxib Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Delivery. Postpartum. Lactation Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Fetal Development - drug effects Gynecology. Andrology. Obstetrics Histocytochemistry Intensive care medicine Kidney - drug effects Kidney - embryology Kidney - enzymology Kidney - metabolism Maternal Exposure Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis Medical sciences Obstetric Labor, Premature - prevention & control Organ Size - drug effects Original Paper Pregnancy Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandin-Endoperoxide Synthases - secretion Pyrazoles - pharmacology Rabbits Random Allocation Receptors, Vascular Endothelial Growth Factor - metabolism Sulfonamides - pharmacology Tissue Inhibitor of Metalloproteinase-1 - biosynthesis Tissue Inhibitor of Metalloproteinase-2 - biosynthesis Vascular Endothelial Growth Factor A - biosynthesis
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