Unparalleled Complexity of the MHC Class I Region in Rhesus Macaques
The highly polymorphic gene products of the classical MHC class I genes in humans (HLA-A, HLA-B, and HLA-C) play a critical role in the immune defense against intracellular infections. Because non-human primates are important models for AIDS vaccine research, rhesus monkeys from a thoroughly pedigre...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2005-02, Vol.102 (5), p.1626-1631 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Otting, Nel Corrine M. C. Heijmans Noort, Riet C. de Groot, Natasja G. Gaby G. M. Doxiadis van Rood, Jon J. Watkins, David I. Bontrop, Ronald E. |
| description | The highly polymorphic gene products of the classical MHC class I genes in humans (HLA-A, HLA-B, and HLA-C) play a critical role in the immune defense against intracellular infections. Because non-human primates are important models for AIDS vaccine research, rhesus monkeys from a thoroughly pedigreed and serotyped colony were subjected to full-length cDNA analysis of MHC class I gene transcripts. Rhesus macaques express multiple dominant Mamu-A and Mamu-B transcripts (majors) per chromosome, which are characterized by high expression levels. The presence of additional cDNAs with low levels of expression (minors) suggests evidence for transcriptional control of MHC class I genes. Moreover, phylogenetic analyses illustrate that most of the Mamu-A and Mamu-B loci/lineages identified display no or only limited levels of allelic polymorphism. Thus, MHC class I diversity in rhesus macaques is typified by the existence of an unmatched high number of Mamu-A and Mamu-B region configurations that exhibit polymorphism with regard to the number and combination of transcribed loci present per chromosome. |
| doi_str_mv | 10.1073/pnas.0409084102 |
| format | Article |
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C. Heijmans ; Noort, Riet C. ; de Groot, Natasja G. ; Gaby G. M. Doxiadis ; van Rood, Jon J. ; Watkins, David I. ; Bontrop, Ronald E.</creator><creatorcontrib>Otting, Nel ; Corrine M. C. Heijmans ; Noort, Riet C. ; de Groot, Natasja G. ; Gaby G. M. Doxiadis ; van Rood, Jon J. ; Watkins, David I. ; Bontrop, Ronald E.</creatorcontrib><description>The highly polymorphic gene products of the classical MHC class I genes in humans (HLA-A, HLA-B, and HLA-C) play a critical role in the immune defense against intracellular infections. Because non-human primates are important models for AIDS vaccine research, rhesus monkeys from a thoroughly pedigreed and serotyped colony were subjected to full-length cDNA analysis of MHC class I gene transcripts. Rhesus macaques express multiple dominant Mamu-A and Mamu-B transcripts (majors) per chromosome, which are characterized by high expression levels. The presence of additional cDNAs with low levels of expression (minors) suggests evidence for transcriptional control of MHC class I genes. Moreover, phylogenetic analyses illustrate that most of the Mamu-A and Mamu-B loci/lineages identified display no or only limited levels of allelic polymorphism. Thus, MHC class I diversity in rhesus macaques is typified by the existence of an unmatched high number of Mamu-A and Mamu-B region configurations that exhibit polymorphism with regard to the number and combination of transcribed loci present per chromosome.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0409084102</identifier><identifier>PMID: 15665097</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Alleles ; Animals ; Biological Sciences ; Chromosomes ; Cloning, Molecular ; Complementary DNA ; Genes ; Genetic loci ; Genetics ; HLA A antigens ; HLA-A Antigens - chemistry ; HLA-A Antigens - genetics ; HLA-A Antigens - immunology ; HLA-B Antigens - chemistry ; HLA-B Antigens - genetics ; HLA-B Antigens - immunology ; HLA-D Antigens - chemistry ; HLA-D Antigens - genetics ; HLA-D Antigens - immunology ; Immunogenetics ; Immunology ; Infections ; Macaca mulatta ; Macaca mulatta - classification ; Macaca mulatta - immunology ; Major Histocompatibility Complex ; MHC class I genes ; Molecular Sequence Data ; Phylogenetics ; Phylogeny ; Polymerase Chain Reaction ; Primates ; Sequencing</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (5), p.1626-1631</ispartof><rights>Copyright 1993/2005 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Feb 1, 2005</rights><rights>Copyright © 2005, The National Academy of Sciences 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-7691a32fed3f1f5283754a6d0b442f9f7c9f09d81b11b6ff2619c1e5dc08f883</citedby><cites>FETCH-LOGICAL-c590t-7691a32fed3f1f5283754a6d0b442f9f7c9f09d81b11b6ff2619c1e5dc08f883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/102/5.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3374481$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3374481$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,729,782,786,805,887,27931,27932,53798,53800,58024,58257</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15665097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otting, Nel</creatorcontrib><creatorcontrib>Corrine M. 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Rhesus macaques express multiple dominant Mamu-A and Mamu-B transcripts (majors) per chromosome, which are characterized by high expression levels. The presence of additional cDNAs with low levels of expression (minors) suggests evidence for transcriptional control of MHC class I genes. Moreover, phylogenetic analyses illustrate that most of the Mamu-A and Mamu-B loci/lineages identified display no or only limited levels of allelic polymorphism. Thus, MHC class I diversity in rhesus macaques is typified by the existence of an unmatched high number of Mamu-A and Mamu-B region configurations that exhibit polymorphism with regard to the number and combination of transcribed loci present per chromosome.</description><subject>Alleles</subject><subject>Animals</subject><subject>Biological Sciences</subject><subject>Chromosomes</subject><subject>Cloning, Molecular</subject><subject>Complementary DNA</subject><subject>Genes</subject><subject>Genetic loci</subject><subject>Genetics</subject><subject>HLA A antigens</subject><subject>HLA-A Antigens - chemistry</subject><subject>HLA-A Antigens - genetics</subject><subject>HLA-A Antigens - immunology</subject><subject>HLA-B Antigens - chemistry</subject><subject>HLA-B Antigens - genetics</subject><subject>HLA-B Antigens - immunology</subject><subject>HLA-D Antigens - chemistry</subject><subject>HLA-D Antigens - genetics</subject><subject>HLA-D Antigens - immunology</subject><subject>Immunogenetics</subject><subject>Immunology</subject><subject>Infections</subject><subject>Macaca mulatta</subject><subject>Macaca mulatta - classification</subject><subject>Macaca mulatta - immunology</subject><subject>Major Histocompatibility Complex</subject><subject>MHC class I genes</subject><subject>Molecular Sequence Data</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Polymerase Chain Reaction</subject><subject>Primates</subject><subject>Sequencing</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1P3DAQxa2qqCy0516qyuJAT4EZx3bsQw9V-gESqBKiZ8ub2GxW3jiNEwT_fRPtioUe2tMc5vdGb94j5D3CGUKRn3etTWfAQYPiCOwVWSBozCTX8JosAFiRKc74ITlKaQ0AWih4Qw5RSClAFwvy9Vfb2d6G4IKraRk3XXAPzfBIo6fDytHri5KWwaZEL-mNu2tiS5uW3qxcGhO9tpX9Pbr0lhx4G5J7t5vH5Pb7t9vyIrv6-eOy_HKVVULDkBVSo82Zd3Xu0Qum8kJwK2tYcs689kWlPeha4RJxKb1nEnWFTtQVKK9Ufkw-b89243Lj6sq1w-TcdH2zsf2jibYxLzdtszJ38d4ILkDJSX-60_dxtj2YTZMqF4JtXRyTkQWfIpL4XxALBUzg7OjkL3Adx76dMjAMMJ_i5nyCzrdQ1ceUeuefHCOYuUUzt2j2LU6Kj88f3fO72p4Bs3J_jhlhULL51U__BIwfQxjcwzCRH7bkOg2xf0LzvOBcYf4Hg-m4fA</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Otting, Nel</creator><creator>Corrine M. 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C. Heijmans</au><au>Noort, Riet C.</au><au>de Groot, Natasja G.</au><au>Gaby G. M. Doxiadis</au><au>van Rood, Jon J.</au><au>Watkins, David I.</au><au>Bontrop, Ronald E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unparalleled Complexity of the MHC Class I Region in Rhesus Macaques</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>102</volume><issue>5</issue><spage>1626</spage><epage>1631</epage><pages>1626-1631</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The highly polymorphic gene products of the classical MHC class I genes in humans (HLA-A, HLA-B, and HLA-C) play a critical role in the immune defense against intracellular infections. Because non-human primates are important models for AIDS vaccine research, rhesus monkeys from a thoroughly pedigreed and serotyped colony were subjected to full-length cDNA analysis of MHC class I gene transcripts. Rhesus macaques express multiple dominant Mamu-A and Mamu-B transcripts (majors) per chromosome, which are characterized by high expression levels. The presence of additional cDNAs with low levels of expression (minors) suggests evidence for transcriptional control of MHC class I genes. Moreover, phylogenetic analyses illustrate that most of the Mamu-A and Mamu-B loci/lineages identified display no or only limited levels of allelic polymorphism. Thus, MHC class I diversity in rhesus macaques is typified by the existence of an unmatched high number of Mamu-A and Mamu-B region configurations that exhibit polymorphism with regard to the number and combination of transcribed loci present per chromosome.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>15665097</pmid><doi>10.1073/pnas.0409084102</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Alleles Animals Biological Sciences Chromosomes Cloning, Molecular Complementary DNA Genes Genetic loci Genetics HLA A antigens HLA-A Antigens - chemistry HLA-A Antigens - genetics HLA-A Antigens - immunology HLA-B Antigens - chemistry HLA-B Antigens - genetics HLA-B Antigens - immunology HLA-D Antigens - chemistry HLA-D Antigens - genetics HLA-D Antigens - immunology Immunogenetics Immunology Infections Macaca mulatta Macaca mulatta - classification Macaca mulatta - immunology Major Histocompatibility Complex MHC class I genes Molecular Sequence Data Phylogenetics Phylogeny Polymerase Chain Reaction Primates Sequencing |
| title | Unparalleled Complexity of the MHC Class I Region in Rhesus Macaques |
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