Kinetics of interconversion of ferrous enzymes, compound II and compound III, of wild-type synechocystis catalase-peroxidase and Y249F: proposal for the catalatic mechanism

With the exception of catalase-peroxidases, heme peroxidases show no significant ability to oxidize hydrogen peroxide and are trapped and inactivated in the compound III form by H2O2 in the absence of one-electron donors. Interestingly, some KatG variants, which lost the catalatic activity, form com...

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Veröffentlicht in:	The Journal of biological chemistry 2005-03, Vol.280 (10), p.9037
Hauptverfasser:	Jakopitsch, Christa, Wanasinghe, Anuruddhika, Jantschko, Walter, Furtmüller, Paul G, Obinger, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Bacterial Proteins - genetics Bacterial Proteins - metabolism Catalase - metabolism Ferrous Compounds - metabolism Hydrogen Peroxide - pharmacology Kinetics Oxygen - metabolism Oxygen Consumption Peroxidases - genetics Peroxidases - metabolism Synechocystis - enzymology Synechocystis - genetics
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