Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin

[6]-Gingerol, a major pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae), has a wide array of pharmacologic effects. Previous studies have demonstrated that [6]-gingerol inhibits mouse skin tumor promotion and anchorage-independent growth of cultured mouse epidermal cells stimu...

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Veröffentlicht in:	BioFactors (Oxford) 2004, Vol.21 (1-4), p.27
Hauptverfasser:	Kim, Sue Ok, Chun, Kyung-Soo, Kundu, Joydeb Kumar, Surh, Young-Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Anticarcinogenic Agents - pharmacology Catechols Cyclooxygenase 2 Enzyme Activation - drug effects Fatty Alcohols - administration & dosage Fatty Alcohols - pharmacology Female Gene Expression Regulation, Enzymologic - drug effects Mice Mice, Inbred ICR NF-kappa B - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Prostaglandin-Endoperoxide Synthases - genetics Skin - drug effects Skin - enzymology Skin - metabolism Tetradecanoylphorbol Acetate - antagonists & inhibitors Tetradecanoylphorbol Acetate - pharmacology Zingiber officinale
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