Pathogenesis of primary inflammatory myopathies
COMMON ELEMENTS: Primary inflammatory myopathies consist of dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM). They have certain characteristics in common: progressive muscle weakness and mononuclear inflammatory infiltrates in the muscle. DIFFERENT MECHANISMS: They may be di...
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| Veröffentlicht in: | La Presse médicale (1983) 2004-11, Vol.33 (20), p.1444 |
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| creator | Benveniste, Olivier Squier, Waney Boyer, Olivier Hilton-Jones, David Herson, Serge |
| description | COMMON ELEMENTS: Primary inflammatory myopathies consist of dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM). They have certain characteristics in common: progressive muscle weakness and mononuclear inflammatory infiltrates in the muscle. DIFFERENT MECHANISMS: They may be distinguished by their histological features which also reflect their different underlying pathogeneses. The mechanism of DM would be complement-mediated microangiopathy, the inflammatory infiltrate of which would be secondary to ischemic phenomena, whereas in PM the muscle fibres are damaged by cytotoxic CD8 T lymphocytes. The factors triggering-off these two forms of myositis remain unknown. IBM may be a degenerative disease with accumulation of a variety of proteins within the fibres. The inflammatory infiltrate, which is similar to that seen in PM, may be a reaction to accumulated proteins. |
| doi_str_mv | 10.1016/S0755-4982(04)98952-X |
| format | Article |
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They have certain characteristics in common: progressive muscle weakness and mononuclear inflammatory infiltrates in the muscle. DIFFERENT MECHANISMS: They may be distinguished by their histological features which also reflect their different underlying pathogeneses. The mechanism of DM would be complement-mediated microangiopathy, the inflammatory infiltrate of which would be secondary to ischemic phenomena, whereas in PM the muscle fibres are damaged by cytotoxic CD8 T lymphocytes. The factors triggering-off these two forms of myositis remain unknown. IBM may be a degenerative disease with accumulation of a variety of proteins within the fibres. The inflammatory infiltrate, which is similar to that seen in PM, may be a reaction to accumulated proteins.</description><identifier>ISSN: 0755-4982</identifier><identifier>DOI: 10.1016/S0755-4982(04)98952-X</identifier><identifier>PMID: 15611679</identifier><language>fre</language><publisher>France</publisher><subject>CD8 Antigens - immunology ; Dermatomyositis - immunology ; Dermatomyositis - pathology ; Dermatomyositis - physiopathology ; Humans ; Muscle, Skeletal - immunology ; Muscle, Skeletal - pathology ; Muscle, Skeletal - physiopathology ; Myositis - immunology ; Myositis - pathology ; Myositis - physiopathology ; Myositis, Inclusion Body - immunology ; Myositis, Inclusion Body - pathology ; Myositis, Inclusion Body - physiopathology ; Polymyositis - immunology ; Polymyositis - pathology ; Polymyositis - physiopathology</subject><ispartof>La Presse médicale (1983), 2004-11, Vol.33 (20), p.1444</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15611679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benveniste, Olivier</creatorcontrib><creatorcontrib>Squier, Waney</creatorcontrib><creatorcontrib>Boyer, Olivier</creatorcontrib><creatorcontrib>Hilton-Jones, David</creatorcontrib><creatorcontrib>Herson, Serge</creatorcontrib><title>Pathogenesis of primary inflammatory myopathies</title><title>La Presse médicale (1983)</title><addtitle>Presse Med</addtitle><description>COMMON ELEMENTS: Primary inflammatory myopathies consist of dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM). They have certain characteristics in common: progressive muscle weakness and mononuclear inflammatory infiltrates in the muscle. DIFFERENT MECHANISMS: They may be distinguished by their histological features which also reflect their different underlying pathogeneses. The mechanism of DM would be complement-mediated microangiopathy, the inflammatory infiltrate of which would be secondary to ischemic phenomena, whereas in PM the muscle fibres are damaged by cytotoxic CD8 T lymphocytes. The factors triggering-off these two forms of myositis remain unknown. IBM may be a degenerative disease with accumulation of a variety of proteins within the fibres. The inflammatory infiltrate, which is similar to that seen in PM, may be a reaction to accumulated proteins.</description><subject>CD8 Antigens - immunology</subject><subject>Dermatomyositis - immunology</subject><subject>Dermatomyositis - pathology</subject><subject>Dermatomyositis - physiopathology</subject><subject>Humans</subject><subject>Muscle, Skeletal - immunology</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Myositis - immunology</subject><subject>Myositis - pathology</subject><subject>Myositis - physiopathology</subject><subject>Myositis, Inclusion Body - immunology</subject><subject>Myositis, Inclusion Body - pathology</subject><subject>Myositis, Inclusion Body - physiopathology</subject><subject>Polymyositis - immunology</subject><subject>Polymyositis - pathology</subject><subject>Polymyositis - physiopathology</subject><issn>0755-4982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9jk1LAzEURbNQbK3-BGWWuoh9L1-TLKVYFQoKKrgryeSNjjSdoRkX_fcGrK4u93C5HMYuEG4Q0MxfoNaaK2fFFahrZ50W_P2ITf_xhJ3m_AUgUNXuhE1QG0RTuymbP_vxs_-gLeUuV31bDbsu-d2-6rbtxqfkx76UtO-Hsuson7Hj1m8ynR9yxt6Wd6-LB756un9c3K74gGBHTrF25IWRWhtQ1gUbSGKQhaEE2chGCSx2PoKqSYJTTTRBRSuKbiQvZ-zy93f4Doni-qC1_jOXP0NURG8</recordid><startdate>20041120</startdate><enddate>20041120</enddate><creator>Benveniste, Olivier</creator><creator>Squier, Waney</creator><creator>Boyer, Olivier</creator><creator>Hilton-Jones, David</creator><creator>Herson, Serge</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20041120</creationdate><title>Pathogenesis of primary inflammatory myopathies</title><author>Benveniste, Olivier ; Squier, Waney ; Boyer, Olivier ; Hilton-Jones, David ; Herson, Serge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p108t-ed79ea2635560489b8be31b3ea21303c3c421755ad047e3094cd6b4d82498dea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2004</creationdate><topic>CD8 Antigens - immunology</topic><topic>Dermatomyositis - immunology</topic><topic>Dermatomyositis - pathology</topic><topic>Dermatomyositis - physiopathology</topic><topic>Humans</topic><topic>Muscle, Skeletal - immunology</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Myositis - immunology</topic><topic>Myositis - pathology</topic><topic>Myositis - physiopathology</topic><topic>Myositis, Inclusion Body - immunology</topic><topic>Myositis, Inclusion Body - pathology</topic><topic>Myositis, Inclusion Body - physiopathology</topic><topic>Polymyositis - immunology</topic><topic>Polymyositis - pathology</topic><topic>Polymyositis - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benveniste, Olivier</creatorcontrib><creatorcontrib>Squier, Waney</creatorcontrib><creatorcontrib>Boyer, Olivier</creatorcontrib><creatorcontrib>Hilton-Jones, David</creatorcontrib><creatorcontrib>Herson, Serge</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>La Presse médicale (1983)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benveniste, Olivier</au><au>Squier, Waney</au><au>Boyer, Olivier</au><au>Hilton-Jones, David</au><au>Herson, Serge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathogenesis of primary inflammatory myopathies</atitle><jtitle>La Presse médicale (1983)</jtitle><addtitle>Presse Med</addtitle><date>2004-11-20</date><risdate>2004</risdate><volume>33</volume><issue>20</issue><spage>1444</spage><pages>1444-</pages><issn>0755-4982</issn><abstract>COMMON ELEMENTS: Primary inflammatory myopathies consist of dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM). 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| ispartof | La Presse médicale (1983), 2004-11, Vol.33 (20), p.1444 |
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| language | fre |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | CD8 Antigens - immunology Dermatomyositis - immunology Dermatomyositis - pathology Dermatomyositis - physiopathology Humans Muscle, Skeletal - immunology Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Myositis - immunology Myositis - pathology Myositis - physiopathology Myositis, Inclusion Body - immunology Myositis, Inclusion Body - pathology Myositis, Inclusion Body - physiopathology Polymyositis - immunology Polymyositis - pathology Polymyositis - physiopathology |
| title | Pathogenesis of primary inflammatory myopathies |
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