Towards structural determination of the ComX pheromone: Synthetic studies on peptides containing geranyltryptophan

Bacteria produce and respond to signal molecules depending on their cell density. This process is called "quorum sensing". The ComX pheromone, controlled by quorum sensing, activates natural genetic competence in Bacillus subtilis. ComX is an oligopeptide with a posttranslational modificat...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2004-11, Vol.68 (11), p.2374-2387
Hauptverfasser:	Okada, M. (Nagoya Univ. (Japan)), Sato, I, Cho, S.J, Suzuki, Y, Ojika, M, Dubnau, D, Sakagami, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	BACILLUS Bacillus subtilis Bacillus subtilis - metabolism Bacterial Proteins - chemical synthesis Bacterial Proteins - chemistry Bacterial Proteins - genetics Biological and medical sciences CHEMICAL REAGENTS Chromatography, High Pressure Liquid Chromatography, Liquid ComX Escherichia coli - metabolism Fundamental and applied biological sciences. Psychology Indicators and Reagents Magnetic Resonance Spectroscopy PEPTIDES Peptides - chemical synthesis PHEROMONES Pheromones - chemical synthesis Pheromones - chemistry Pheromones - genetics posttranslational modification quorum sensing Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Ultraviolet STRUCTURE ACTIVITY RELATIONSHIPS TRYPTOPHAN Tryptophan - analogs & derivatives Tryptophan - analysis Tryptophan - biosynthesis Tryptophan - chemistry
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